Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,132

Participants

Timeline

Start Date

January 3, 2022

Primary Completion Date

January 19, 2026

Study Completion Date

March 23, 2026

Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
DRUG

Tozorakimab

Administered subcutaneously tozorakimab Dose 1 and placebo through Week 52.

DRUG

Tozorakimab

Administered subcutaneously tozorakimab Dose 2 through Week 52.

DRUG

Placebo

Placebo administered subcutaneously, equivalent volume to tozorakimab through week 52.

Trial Locations (212)

1000

Research Site, Brussels

Research Site, Sofia

1036

Research Site, Budapest

1478

Research Site, Lørenskog

1606

Research Site, Sofia

1888

Research Site, San Juan Bautista

2400

Research Site, København NV

2440

Research Site, Százhalombatta

2600

Research Site, Dupnitsa

2650

Research Site, Hvidovre

2850

Research Site, Petrich

3000

Research Site, Leuven

Research Site, Vratsa

3103

Research Site, Tønsberg

3320

Research Site, Kozloduy

3780

Research Site, Edelény

3860

Research Site, Encs

4000

Research Site, San Miguel de Tucumán

Research Site, Liège

Research Site, Roskilde

4032

Research Site, Debrecen

4481

Research Site, Nyíregyháza-Sóstóhegy

4700

Research Site, Næstved

5021

Research Site, Bergen

5101

Research Site, Namur

5500

Research Site, Lovech

5600

Research Site, Troyan Municipality

5800

Research Site, Pleven

6017

Research Site, Ålesund

6305

Research Site, Haskovo

7002

Research Site, Rousse

7100

Research Site, Vejle

7600

Research Site, Mar del Plata

Research Site, Levanger

8092

Research Site, Bodø

8800

Research Site, Sliven

9000

Research Site, Ghent

Research Site, Aalborg

9200

Research Site, Mosonmagyaróvár

10037

Research Site, New York

10455

Research Site, The Bronx

11239

Research Site, Stockholm

13530

Research Site, Hämeenlinna

15213

Research Site, Pittsburgh

15801

Research Site, DuBois

18840

Research Site, Sayre

20100

Research Site, Turku

20520

Research Site, Turku

21224

Research Site, Baltimore

21431

Research Site, Incheon

27710

Research Site, Durham

28040

Research Site, Madrid

28054

Research Site, Gastonia

28223

Research Site, Pozuelo de Alarcón

28277

Research Site, Charlotte

29010

Research Site, Málaga

31000

Research Site, Chihuahua City

32174

Research Site, Ormond Beach

33324

Research Site, Plantation

33343

Research Site, Mersin

33435

Research Site, Boynton Beach

33520

Research Site, Tampere

34069

Research Site, Istanbul

35040

Research Site, Izmir

35801

Research Site, Huntsville

35965

Research Site, Izmir

36106

Research Site, Montgomery

36608

Research Site, Mobile

37067

Research Site, Franklin

39008

Research Site, Santander

42415

Research Site, Daegu

44100

Research Site, Guadalajara

44200

Research Site, Guadalajara

46010

Research Site, Valencia

48960

Research Site, Galdakao

50009

Research Site, Zaragoza

52242

Research Site, Iowa City

54907

Research Site, Jeonju

55001

Research Site, Broumov

55905

Research Site, Rochester

57702

Research Site, Rapid City

58000

Research Site, Morelia

58104

Research Site, Fargo

59808

Research Site, Missoula

60805

Research Site, Evergreen Park

61761

Research Site, Normal

63110

Research Site, St Louis

64460

Research Site, Monterrey

66104

Research Site, Kansas City

68020

Research Site, Oaxaca City

70210

Research Site, Kuopio

70791

Research Site, Zachary

70816

Research Site, Baton Rouge

77022

Research Site, Houston

77339

Research Site, Kingwood

83642

Research Site, Meridian

84108

Research Site, Salt Lake City

85283

Research Site, Tempe

91910

Research Site, Veracruz

93301

Research Site, Bakersfield

95821

Research Site, Sacramento

97070

Research Site, Mérida

100000

Research Site, Hanoi

110029

Research Site, New Delhi

160062

Research Site, Mohali

248001

Research Site, Dehradun

302039

Research Site, Jaipur

382415

Research Site, Ahmedabad

395009

Research Site, Surat

401107

Research Site, Thāne

422007

Research Site, Nashik

440012

Research Site, Nagpur

500038

Research Site, Hyderabad

590010

Research Site, Belagavi

641028

Research Site, Coimbatore

700000

Research Site, Ho Chi Minh City

08724

Research Site, Brick

05401

Research Site, Burlington

C1121 ABE

Research Site, Buenos Aires

C1414AIF

Research Site, Buenos Aires

C1425BEN

Research Site, CABA

X5003DCE

Research Site, Córdoba

B7600GWV

Research Site, Mar del Plata

M5500CCG

Research Site, Mendoza

B1878FNR

Research Site, Quilmes

B1646EBJ

Research Site, San Fernando

T3E 7M8

Research Site, Calgary

T5A 4L8

Research Site, Edmonton

T8L 0N2

Research Site, Sherwood Park

V2C 5T1

Research Site, Kamloops

V1Y 4N7

Research Site, Kelowna

L1S 2J5

Research Site, Ajax

N1H 6J2

Research Site, Guelph

L3T 0C8

Research Site, Markham

L4A 1H2

Research Site, Stouffville

K0C 2K0

Research Site, Winchester

H3T 1E2

Research Site, Montreal

G1G 3Y8

Research Site, Québec

G1V 4G5

Research Site, Québec

J6V 2H2

Research Site, Terrebonne

625 00

Research Site, Brno

377 01

Research Site, Jindřichův Hradec

460 63

Research Site, Liberec

779 00

Research Site, Olomouc

337 22

Research Site, Rokycany

00290

Research Site, Helsinki

078-8510

Research Site, Asahikawa-shi

818-8502

Research Site, Chikushino-shi

103-0022

Research Site, Chūōku

426-8677

Research Site, Fujieda-shi

819-8555

Research Site, Fukuoka

430-8525

Research Site, Hamamatsu

431-3192

Research Site, Hamamatsu

734-8530

Research Site, Hiroshima

820-8505

Research Site, Iizuka-shi

173-8610

Research Site, Itabashi-ku

438-8550

Research Site, Iwata-shi

610-0113

Research Site, Joyo-shi

890-8520

Research Site, Kagoshima

920-8650

Research Site, Kanazawa

586-8521

Research Site, Kawachinagano-shi

806-8501

Research Site, Kitakyusyu-shi

651-0072

Research Site, Kobe

811-3195

Research Site, Koga-shi

185-0014

Research Site, Kokubunji-shi

515-8544

Research Site, Matsusaka-shi

509-6134

Research Site, Mizunami-shi

940-8621

Research Site, Nagaoka-shi

460-0001

Research Site, Nagoya

080-0017

Research Site, Obihiro

700-8558

Research Site, Okayama

531-0073

Research Site, Osaka

543-8555

Research Site, Osaka

545-8586

Research Site, Osaka

590-0064

Research Site, Sakaishi

162-8655

Research Site, Shinjuku-ku

420-8630

Research Site, Shizuoka

170-0003

Research Site, Toshima-ku

560-8552

Research Site, Toyonaka-shi

832-0059

Research Site, Yanagawa-shi

221-0855

Research Site, Yokohama

223-0059

Research Site, Yokohama

232-0024

Research Site, Yokohama

03650

Research Site, Benito Juárez

0 3100

Research Site, Mexico City

1815 JD

Research Site, Alkmaar

5623EJ

Research Site, Eindhoven

9713 GZ

Research Site, Groningen

3844 DG

Research Site, Harderwijk

6419 PC

Research Site, Heerlen

7207 AE

Research Site, Zutphen

8025 AB

Research Site, Zwolle

0450

Research Site, Oslo

4835-235

Research Site, Guimarães

1769-001

Research Site, Lisbon

1998-018

Research Site, Lisbon

4454-509

Research Site, Matosinhos Municipality

2600-009

Research Site, Vila Franca de Xira

4434-502

Research Site, Vila Nova de Gaia

00968

Research Site, Guaynabo

03722

Research Site, Seoul

05030

Research Site, Seoul

05505

Research Site, Seoul

06591

Research Site, Seoul

07061

Research Site, Seoul

06800

Research Site, Mérida

413 45

Research Site, Gothenburg

413 46

Research Site, Gothenburg

222 22

Research Site, Lund

205 02

Research Site, Malmo

06620

Research Site, Ankara

09100

Research Site, Aydin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY