A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

594

Participants

Timeline

Start Date

September 15, 2022

Primary Completion Date

October 6, 2025

Study Completion Date

October 6, 2025

Conditions
Advanced or Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG

Ceralasertib

Participants will receive ceralasertib oral tablets.

DRUG

Durvalumab

Participants will receive durvalumab as an intravenous infusion.

DRUG

Docetaxel

Participants will received docetaxel as an intravenous infusion.

Trial Locations (193)

640

Research Site, Yunlin

704

Research Site, Tainan City

1058

Research Site, Buenos Aires

1121

Research Site, Budapest

2480

Research Site, Lismore

2500

Research Site, Wollongong

4101

Research Site, South Brisbane

5112

Research Site, Elizabeth Vale

5400

Research Site, San Juan

6000

Research Site, Charleroi

6150

Research Site, Murdoch

6800

Research Site, Libramont-Chevigny

8000

Research Site, Székesfehérvár

8003

Research Site, Barcelona

8035

Research Site, Barcelona

8800

Research Site, Roeselare

9000

Research Site, Ghent

11080

Research Site, Belgrade

11217

Research Site, Taipei

12002

Research Site, Castellon

12351

Research Site, Berlin

14004

Research Site, Córdoba

15006

Research Site, A Coruña

15009

Research Site, A Coruña

16247

Research Site, Suwon

17403

Research Site, York

18103

Research Site, Allentown

20089

Research Site, Rozzano

20133

Research Site, Milan

20817

Research Site, Bethesda

20852

Research Site, Rockville

20900

Research Site, Monza

21231

Research Site, Baltimore

27103

Research Site, Winston-Salem

28040

Research Site, Madrid

28046

Research Site, Madrid

28204

Research Site, Charlotte

28223

Research Site, Pozuelo de Alarcón

28644

Research Site, Cheongju-si

29009

Research Site, Málaga

30318

Research Site, Atlanta

30607

Research Site, Athens

31008

Research Site, Pamplona

32005

Research Site, Ourense

32256

Research Site, Jacksonville

32804

Research Site, Orlando

33081

Research Site, Aviano

33604

Research Site, Pessac

33612

Research Site, Tampa

34070

Research Site, Montpellier

35128

Research Site, Padua

36607

Research Site, Mobile

37126

Research Site, Verona

39401

Research Site, Hattiesburg

40201

Research Site, Taichung

40705

Research Site, Taichung

41014

Research Site, Servilla

43126

Research Site, Parma

44093

Research Site, Nantes

44106

Research Site, Cleveland

44718

Research Site, Canton

44805

Research Site, Saint-Herblain

46804

Research Site, Fort Wayne

47014

Research Site, Meldola

47441

Research Site, Moers

49933

Research Site, Angers

50009

Research Site, Zaragoza

54911

Research Site, Appleton

57070

Research Site, Vantoux

57124

Research Site, Livorno

63011

Research Site, Clermont-Ferrand

63110

Research Site, St Louis

68114

Research Site, Omaha

69373

Research Site, Lyon

69655

Research Site, Villefranche-sur-Saône

74245

Research Site, Löwenstein

75014

Research Site, Paris

76137

Research Site, Karlsruhe

77090

Research Site, Houston

77339

Research Site, Kingwood

77340

Research Site, Huntsville

79106

Research Site, Freiburg im Breisgau

80131

Research Site, Napoli

82131

Research Site, Gauting

85224

Research Site, Chandler

87439

Research Site, Kempten

89511

Research Site, Reno

90017

Research Site, Los Angeles

90603

Research Site, Whittier

90720

Research Site, Los Alamitos

92140

Research Site, Clamart

94010

Research Site, Créteil

94805

Research Site, Villejuif

100021

Research Site, Beijing

100044

Research Site, Beijing

150001

Research Site, King's Park

200347

Research Site, Craiova

200385

Research Site, Craiova

210029

Research Site, Nanjing

230001

Research Site, Hefei

250013

Research Site, Jinan

266071

Research Site, Qingdao

276000

Research Site, Linyi

300052

Research Site, Tianjin

300060

Research Site, Tianjin

300166

Research Site, Timișoara

300239

Research Site, Timișoara

302017

Research Site, Jaipur

310009

Research Site, Hangzhou

330000

Research Site, Nanchang

333423

Research Site, Taoyuan District

395002

Research Site, Surat

400015

Research Site, Cluj-Napoca

400641

Research Site, Cluj-Napoca

407280

Research Site, Floreşti

410008

Research Site, Changsha

410469

Research Site, Oradea

411001

Research Site, Pune

422011

Research Site, Nashik

430000

Research Site, Wuhan

430022

Research Site, Wuhan

430079

Research Site, Wuhan

450008

Research Site, Zhengzhou

510080

Research Site, Guangzhou

524001

Research Site, Zhanjiang

530021

Research Site, Nanning

610041

Research Site, Chengdu

618000

Research Site, Deyang

999077

Research Site, Hong Kong

B2700CPM

Research Site, Pergamino

S2000DSV

Research Site, Rosario

S2000KZE

Research Site, Rosario

60810-180

Research Site, Fortaleza

90110-270

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

40170-110

Research Site, Salvador

01246-000

Research Site, São Paulo

09323-900

Research Site, São Paulo

VSZ 4E6

Research Site, Vancouver

L3Y 2P9

Research Site, Newmarket

G7H 7P2

Research Site, Chicoutimi

H2L 4M1

Research Site, Montreal

H3G 1A4

Research Site, Montreal

G1V 4G5

Research Site, Québec

G5L 5T1

Research Site, Rimouski

071000

Research Site, Baoding

030000

Research Site, Taiyuan

02321

Research Site, Saint-Quentin

Unknown

Research Site, Tun Mun

Research Site, Dublin

Research Site, Guildford

T12 DV56

Research Site, Cork

D09 V2N0

Research Site, Dublin

V94 F858

Research Site, Limerick

06129

Research Site, Perugia

00128

Research Site, Roma

113-8431

Research Site, Bunkyō City

113-8677

Research Site, Bunkyō City

104-0045

Research Site, Chūōku

135-8550

Research Site, Kōtoku

710-8602

Research Site, Kurashiki-shi

830-0011

Research Site, Kurume-shi

791-0280

Research Site, Matsuyama

460-0001

Research Site, Nagoya

951-8566

Research Site, Niigata

541-8567

Research Site, Osaka

591-8555

Research Site, Sakaishi

003-0804

Research Site, Sapporo

980-0873

Research Site, Sendai

411-8777

Research Site, Sunto-gun

470-1192

Research Site, Toyoake-shi

241-8515

Research Site, Yokohama

6419 PC

Research Site, Heerlen

5022 GC

Research Site, Tilburg

80-952

Research Site, Gdansk

30-727

Research Site, Krakow

31-826

Research Site, Krakow

60-693

Research Site, Poznan

60-185

Research Site, Skórzewo

022328

Research Site, Bucharest

031422

Research Site, Bucharest

03080

Research Site, Seoul

03181

Research Site, Seoul

03722

Research Site, Seoul

07061

Research Site, Seoul

138-736

Research Site, Seoul

08041

Research Site, Barcelona

08907

Research Site, Hospitalet deLlobregat

07198

Research Site, Palma de Mallorca

08208

Research Site, Sabadell

CH63 4JY

Research Site, Metropolitan Borough of Wirral

SG1 4AB

Research Site, Stevenage

SM2 5PT

Research Site, Sutton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY

NCT05450692 - A Phase III Study of Ceralasertib Plus Durvalumab Versus Docetaxel in Patients With Non Small Cell Lung Cancer (NSCLC) Whose Disease Progressed On or After Prior Anti PD (L)1 Therapy And Platinum Based Chemotherapy | Biotech Hunter | Biotech Hunter