Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,035

Participants

Timeline

Start Date

March 25, 2022

Primary Completion Date

March 4, 2026

Study Completion Date

March 4, 2026

Conditions
Prostate Cancer
Interventions
DRUG

capivasertib

"320 mg (2 tablets) BD given on an intermittent weekly dosing schedule. Patients will be dosed on Days 2 to 5, 9 to 12, and 16 to 19 in each week of a 21-day treatment cycle.~Number of Cycles: until disease progression or unacceptable toxicity develops, death, or if the patient requests to stop the study treatment."

DRUG

docetaxel

Patients will receive docetaxel in intravenous infusion, 75 mg/m2 BSA, on Day 1 of the 21-day cycles for up to 6 to 10 cycles, according to standard of care practices.

OTHER

placebo

matched to capivasertib appearance (2 tablets) BD given orally on an intermittent weekly dosing schedule. Patients will be dosed on Days 2 to 5, 9 to 12, and 16 to 19 in each week of a 21-day treatment cycle. Number of Cycles: until disease progression or unacceptable toxicity develops, death, or if the patient requests to stop the study treatment.

Trial Locations (217)

704

Research Site, Tainan City

710

Research Site, Tainan City

1097

Research Site, Budapest

1122

Research Site, Budapest

1125

Research Site, Budapest

1145

Research Site, Budapest

2076

Research Site, Wahroonga

2217

Research Site, Kogarah

2800

Research Site, Orange

2930

Research Site, Brasschaat

4000

Research Site, Liège

4020

Research Site, Redcliffe

4120

Research Site, Greenslopes

4400

Research Site, Nyíregyháza

4575

Research Site, Birtinya

5000

Research Site, North Adelaide

Research Site, Szolnok

6000

Research Site, Kecskemét

6273

Research Site, Seoul

6725

Research Site, Szeged

9000

Research Site, Ghent

10002

Research Site, Taipei

10034

Research Site, Prague

10408

Research Site, Goyang-si

10461

Research Site, The Bronx

10601

Research Site, White Plains

11259

Research Site, Taipei

12208

Research Site, Albany

14004

Research Site, Córdoba

14059

Research Site, Prague

19107

Research Site, Philadelphia

19111

Research Site, Philadelphia

20116

Research Site, Aguascalientes

21201

Research Site, Baltimore

21287

Research Site, Baltimore

22030

Research Site, Edirne

23320

Research Site, Chesapeake

26504

Research Site, Pátrai

27003

Research Site, Lugo

27310

Research Site, Şahinbey

28034

Research Site, Madrid

28040

Research Site, Madrid

29010

Research Site, Málaga

29605

Research Site, Greenville

29609

Research Site, Brest

33076

Research Site, Bordeaux

34298

Research Site, Montpellier

35575

Research Site, Izmir

37203

Research Site, Nashville

37404

Research Site, Chattanooga

40447

Research Site, Taichung

41013

Research Site, Seville

41404

Research Site, Bukgu

43623

Research Site, Toledo

44260

Research Site, Guadalajara

44281

Research Site, Kfar Saba

44680

Research Site, Guadalajara

44805

Research Site, Saint-Herblain

45116

Research Site, Zapopan

52621

Research Site, Ramat Gan

54000

Research Site, Vandœuvre-lès-Nancy

55404

Research Site, Minneapolis

55416

Research Site, Minneapolis

57201

Research Site, Watertown

63011

Research Site, Clermont-Ferrand

67000

Research Site, Strasbourg

67033

Research Site, Strasbourg

68000

Research Site, Oaxaca City

70300

Research Site, Be’er Ya‘aqov

75014

Research Site, Paris

75020

Research Site, Paris

75235

Research Site, Dallas

76031

Research Site, Rouen

77096

Research Site, Houston

77339

Research Site, Kingwood

78217

Research Site, San Antonio

78731

Research Site, Austin

80045

Research Site, Aurora

80120

Research Site, Littleton

80228

Research Site, Lakewood

80230

Research Site, Culiacán

81362

Research Site, Kaohsiung City

85364

Research Site, Yuma

90095

Research Site, Los Angeles

90211

Research Site, Beverly Hills

90404

Research Site, Santa Monica

90703

Research Site, Cerritos

91120

Research Site, Jerusalem

93105

Research Site, Santa Barbara

93701

Research Site, Fresno

94010

Research Site, Créteil

94115

Research Site, San Francisco

94160

Research Site, Saint-Mandé

94805

Research Site, Villejuif

95403

Research Site, Santa Rosa

95817

Research Site, Sacramento

97223

Research Site, Portland

98109

Research Site, Seattle

100021

Research Site, Beijing

100034

Research Site, Beijing

100050

Research Site, Beijing

110042

Research Site, Shenyang

110085

Research Site, New Delhi

150040

Research Site, Harbin

160055

Research Site, Mohali

200032

Research Site, Shanghai

200040

Research Site, Shanghai

210008

Research Site, Nanjing

226361

Research Site, Nantong

250001

Research Site, Meerut

264000

Research Site, Yantai

300052

Research Site, Tianjin

310000

Research Site, Hangzhou

310003

Research Site, Hangzhou

314001

Research Site, Jiaxing

315010

Research Site, Ningbo

330019

Research Site, Nanchang

334003

Research Site, Bikaner

400038

Research Site, Chongqing

410008

Research Site, Changsha

410013

Research Site, Changsha

430030

Research Site, Wuhan

430079

Research Site, Wuhan

450008

Research Site, Zhengzhou

510180

Research Site, Guangzhou

610041

Research Site, Chengdu

610072

Research Site, Chengdu

2520000

Research Site, Viña del Mar

3109601

Research Site, Haifa

4941492

Research Site, Petah Tikva

6423906

Research Site, Tel Aviv

7500713

Research Site, Santiago

7500918

Research Site, Santiago

7650568

Research Site, Santiago

07601

Research Site, Hackensack

19004-1017

Research Site, Bala-Cynwyd

29308-014

Research Site, Cachoeiro de Itapemirim

98700-000

Research Site, Ijuí

88301-220

Research Site, Itajaí

89201-470

Research Site, Joinville

90020-090

Research Site, Porto Alegre

90035-903

Research Site, Porto Alegre

90110-270

Research Site, Porto Alegre

90160-093

Research Site, Porto Alegre

50040-000

Research Site, Recife

22281-100

Research Site, Rio de Janeiro

22793-080

Research Site, Rio de Janeiro

41253-190

Research Site, Salvador

41820-021

Research Site, Salvador

97015-450

Research Site, Santa Maria

15090-000

Research Site, São José Do Rio Preto - SP

01221-020

Research Site, São Paulo

01509-900

Research Site, São Paulo

04014-002

Research Site, São Paulo

79601-001

Research Site, Três Lagoas

B3H 2Y9

Research Site, Halifax

L1G 2B9

Research Site, Oshawa

M5G 2M9

Research Site, Toronto

H3T 1E2

Research Site, Montreal

J1H 5N4

Research Site, Sherbrooke

M4N 3M5

Research Site, Toronto

268 01

Research Site, Hořovice

500 05

Research Site, Hradec Králové

532 03

Research Site, Pardubice

150 06

Research Site, Prague

115 22

Research Site, Athens

155 62

Research Site, Athens

124 62

Research Site, Chaïdári

151 23

Research Site, Marousi

185 47

Research Site, Piraeus

260-8717

Research Site, Chiba

573-1191

Research Site, Hirakata-shi

036-8563

Research Site, Hirosaki-shi

920-8641

Research Site, Kanazawa

634-8522

Research Site, Kashihara-shi

761-0793

Research Site, Kita-gun

650-0047

Research Site, Kobe

860-0008

Research Site, Kumamoto

889-1692

Research Site, Miyazaki

381-8551

Research Site, Nagano

466-8560

Research Site, Nagoya

164-0001

Research Site, Nakano

541-8567

Research Site, Osaka

589-8511

Research Site, Osakasayama-shi

252-0375

Research Site, Sagamihara-shi

003-0804

Research Site, Sapporo

514-8507

Research Site, Tsu

641-8510

Research Site, Wakayama

232-0024

Research Site, Yokohama

03840

Research Site, Mexico City

04700

Research Site, México

2134 TM

Research Site, Hoofddorp

2545 CH

Research Site, The Hague

67-106

Research Site, Nowa Sól

45-061

Research Site, Opole

05-135

Research Site, Wieliszew

602-739

Research Site, Busan

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06591

Research Site, Seoul

08003

Research Site, Barcelona

08035

Research Site, Barcelona

08036

Research Site, Barcelona

?08041

Research Site, Barcelona

08208

Research Site, Sabadell

01060

Research Site, Adana

01240

Research Site, Yüreğir

EH4 2XU

Research Site, Edinburgh

G12 0YN

Research Site, Glasgow

Unknown

Research Site, Guildford

07601-1963

Research Site, Hackensack

SE1 9RT

Research Site, London

SW7 3RP

Research Site, London

M20 4BX

Research Site, Manchester

SO16 6YD

Research Site, Southampton

SM2 5PT

Research Site, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY