A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

August 11, 2022

Primary Completion Date

April 12, 2024

Study Completion Date

November 2, 2026

Conditions
Melanoma
Interventions
DRUG

Ceralasertib

Ceralasertib (240 mg) will be administered orally twice daily.

BIOLOGICAL

Durvalumab

Durvalumab (1500 mg) will be administered intravenously once every 28 days for participants who weight above \> 30 kgs. For participants who weigh below ≤ 30 kgs, weight-based dosing equivalent to 20 mg/kg of durvalumab will be administered.

Trial Locations (66)

1200

Research Site, Belgium

2010

Research Site, Darlinghurst

3000

Research Site, Leuven

3002

Research Site, East Melbourne

4029

Research Site, Herston

4102

Research Site, Woolloongabba

8000

Research Site, Bruges

9000

Research Site, Ghent

10060

Research Site, Candiolo

10117

Research Site, Berlin

13385

Research Site, Marseille

19049

Research Site, Schwerin

20141

Research Site, Milan

21093

Research Site, Lutherville-Timonium

21614

Research Site, Buxtehude

24105

Research Site, Kiel

28007

Research Site, Madrid

28027

Research Site, Madrid

28034

Research Site, Madrid

28040

Research Site, Madrid

28223

Research Site, Pozuelo de Alarcón

29009

Research Site, Málaga

31008

Research Site, Pamplona

33612

Research Site, Tampa

35128

Research Site, Padua

37232

Research Site, Nashville

53100

Research Site, Siena

54511

Research Site, Vandœuvre-lès-Nancy

55131

Research Site, Mainz

64046

Research Site, Pau

69120

Research Site, Heidelberg

69310

Research Site, Pierre-Bénite

74078

Research Site, Heilbronn

75010

Research Site, Paris

80131

Research Site, Napoli

80337

Research Site, München

86021

Research Site, Poitiers

90024

Research Site, Los Angeles

92100

Research Site, Boulogne-Billancourt

93009

Research Site, Bobigny

93053

Research Site, Regensburg

94143

Research Site, San Francisco

94805

Research Site, Villejuif

95816

Research Site, Sacramento

t6G1Z2

Research Site, Edmonton

M4N 3M5

Research Site, Toronto

M5G 2M9

Research Site, Toronto

G1V 4G2

Research Site, Ste-Foy

D-72076

Research Site, Tübingen

06156

Research Site, Perugia

00168

Research Site, Roma

36-200

Research Site, Brzozów

80-214

Research Site, Gdansk

31-115

Research Site, Krakow

93-513

Research Site, Lodz

60-355

Research Site, Poznan

02-781

Research Site, Warsaw

410-769

Research Site, Goyang

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

08041

Research Site, Barcelona

CB2 0QQ

Research Site, Cambridge

SW3 6JJ

Research Site, Chelsea

M20 4BX

Research Site, Manchester

HA6 2RN

Research Site, Northwood

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY