Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,683

Participants

Timeline

Start Date

August 2, 2022

Primary Completion Date

May 31, 2028

Study Completion Date

May 31, 2028

Conditions
Intracranial ArteriosclerosisStroke
Interventions
DRUG

Ticagrelor + Aspirin

ticagrelor (180 mg loading dose, then 90mg twice daily) and aspirin (81mg daily)

DRUG

Rivaroxaban + Aspirin

low dose rivaroxaban (2.5mg twice daily) and aspirin (81mg daily)

DRUG

Clopidogrel + Aspirin

clopidogrel (600mg loading dose, then 75mg daily) and aspirin (81mg daily)

OTHER

Risk Factor Management

Risk factors for stroke (LDL, blood pressure, non-HDL cholesterol, diabetes, smoking, weight, and physical activity) will be monitored and managed.

Trial Locations (129)

10016

WITHDRAWN

NYU Langone Medical Center - Tisch Hospital, New York

10021

RECRUITING

NYP Weill Cornell Medical Center, New York

10029

RECRUITING

The Mount Sinai Hospital, New York

10032

RECRUITING

NYP Columbia University Medical Center, New York

10467

TERMINATED

Montefiore Medical Center, The Bronx

11042

RECRUITING

North Shore University Hospital, Lake Success

11203

RECRUITING

Kings County Hospital Center, Brooklyn

RECRUITING

SUNY Downstate Medical Center, Brooklyn

11219

WITHDRAWN

Maimonides Medical Center, Brooklyn

11220

RECRUITING

NYU Langone Hospital - Brooklyn, Brooklyn

14202

RECRUITING

Buffalo General Medical Center, Buffalo

14642

ACTIVE_NOT_RECRUITING

Strong Memorial Hospital, Rochester

15213

RECRUITING

UPMC Presbyterian Hospital, Pittsburgh

16550

RECRUITING

UPMC Hamot, Erie

16601

TERMINATED

UPMC Altoona, Altoona

19001

RECRUITING

Jefferson Abington Hospital, Abington

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19140

RECRUITING

Temple University Hospital, Philadelphia, Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

21201

TERMINATED

University of Maryland Medical Center, Baltimore

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22903

RECRUITING

UVA Medical Center, Charlottesville

24011

RECRUITING

Carilion Roanoke Memorial Hospital, Roanoke

26506

WITHDRAWN

WVU Healthcare Ruby Memorial Hospital, Morgantown

27157

RECRUITING

Wake Forest Baptist Medical Center, Winston-Salem

27405

RECRUITING

Moses H. Cone Memorial Hospital, Greensboro

27710

RECRUITING

Duke University Hospital, Durham

27834

RECRUITING

ECU Health Medical Center, Greenville

28207

RECRUITING

Carolinas Medical Center, Charlotte

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

29425

RECRUITING

Medical University of South Carolina University Hospital, Charleston

29605

RECRUITING

Prisma Health Greenville Memorial Hospital, Greenville

30303

RECRUITING

Emory University Hospital, Atlanta

RECRUITING

Grady Memorial Hospital, Atlanta

30912

TERMINATED

Augusta University Medical Center, Augusta

32207

RECRUITING

Baptist Medical Center Jacksonville, Jacksonville

32224

RECRUITING

Mayo Clinic, Jacksonville

32608

RECRUITING

UF Health Shands Hospital, Gainesville

33136

RECRUITING

Jackson Memorial Hospital, Miami

33316

RECRUITING

Broward Health Medical Center, Fort Lauderdale

33606

TERMINATED

Tampa General Hospital, Tampa

33756

RECRUITING

Morton Plant Hospital, Clearwater

34239

WITHDRAWN

Intercoastal Medical Group - Clinical Research, Sarasota

34987

RECRUITING

Cleveland Clinic Tradition Hospital, Port Saint Lucie

35233

RECRUITING

University of Alabama Hospital, Birmingham

36604

RECRUITING

University of South Alabama University Hospital, Mobile

38104

RECRUITING

Methodist University Hospital, Memphis

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40503

RECRUITING

Baptist Health Lexington, Lexington

40536

TERMINATED

University of Kentucky Hospital, Lexington

43210

RECRUITING

OSU Wexner Medical Center, Columbus

43606

RECRUITING

Toledo Hospital, Toledo

43608

RECRUITING

Mercy St. Vincent Medical Center, Toledo

44106

RECRUITING

UH Cleveland Medical Center, Cleveland

44195

RECRUITING

Cleveland Clinic, Cleveland

44307

RECRUITING

Cleveland Clinic Akron General, Akron

45220

RECRUITING

Good Samaritan Hospital, Cincinnati

45267

RECRUITING

University of Cincinnati Medical Center, Cincinnati

48043

RECRUITING

McLaren Macomb, Mount Clemens

48202

RECRUITING

Henry Ford Hospital, Detroit

48532

RECRUITING

McLaren Flint, Flint

49519

RECRUITING

Metro Health Hospital, Wyoming

52242

WITHDRAWN

University of Iowa Hospitals & Clinics, Iowa City

53226

WITHDRAWN

Froedtert Hospital, Milwaukee

53792

TERMINATED

University of Wisconsin University Hospital, Madison

55407

RECRUITING

Abbott Northwestern Hospital, Minneapolis

55414

RECRUITING

M Health Fairview Southdale Hospital, Edina

55415

RECRUITING

M Health Fairview University of Minnesota Medical Center, Minneapolis

60005

WITHDRAWN

NCH Hospital, Arlington Heights

60201

RECRUITING

Evanston Hospital, Evanston

60453

TERMINATED

Advocate Christ Medical Center, Oak Lawn

60612

RECRUITING

Rush University Medical Center, Chicago

RECRUITING

University of Illinois Hospital, Chicago

60637

RECRUITING

University of Chicago Medical Center, Chicago

61114

RECRUITING

Javon Bea Hospital - Riverside, Rockford

62269

RECRUITING

Barnes Jewish Hospital, St Louis

62901

RECRUITING

Memorial Hospital of Carbondale, Carbondale

65212

RECRUITING

University of Missouri Health Care, Columbia

66160

RECRUITING

University of Kansas Hospital, Kansas City

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70121

RECRUITING

Ochsner Medical Center - Main Campus, New Orleans

73104

RECRUITING

OU Medical Center, Oklahoma City

75075

RECRUITING

Medical City Plano, Plano

75708

RECRUITING

UT Health Tyler, Tyler

77030

RECRUITING

Houston Methodist Hospital, Houston

RECRUITING

Memorial Hermann Texas Medical Center, Houston

77555

RECRUITING

University of Texas Medical Branch, Galveston

78229

RECRUITING

University of Texas Health Science Center San Antonio, San Antonio

79410

RECRUITING

Covenant Medical Center, Lubbock

80045

RECRUITING

University of Colorado Hospital, Aurora

81501

RECRUITING

St. Mary's Medical Center, Grand Junction

84132

WITHDRAWN

University of Utah Healthcare, Salt Lake City

85013

RECRUITING

St. Joseph's Hospital and Medical Center, Phoenix

85054

RECRUITING

Mayo Clinic, Phoenix

85251

WITHDRAWN

HonorHealth Scottsdale Osborn Medical Center, Scottsdale

85724

WITHDRAWN

Banner University Medical Center - Tucson Campus, Tucson

87106

RECRUITING

University of New Mexico Hospital, Albuquerque

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90095

TERMINATED

Ronald Reagan UCLA Medical Center, Los Angeles, CA, Los Angeles

90503

RECRUITING

Providence Little Company of Mary Medical Center Torrance, Torrance

90602

WITHDRAWN

PIH Health Hospital, Whittier

90720

RECRUITING

Los Alamitos Medical Center, Los Alamitos

90806

RECRUITING

Long Beach Memorial Medical Center, Long Beach

91910

RECRUITING

The Neuron Clinic - Chula Vista, Chula Vista

92093

WITHDRAWN

UCSD Health La Jolla, La Jolla

92103

TERMINATED

UCSD Medical Center - Hillcrest Hospital, San Diego

92335

RECRUITING

Kaiser Permanente Fontana Medical Center, Fontana

92868

TERMINATED

UC Irvine Medical Center, Orange

93901

TERMINATED

Salinas Valley Memorial Hospital, Salinas

95608

RECRUITING

Mercy San Juan Medical Center, Carmichael

95817

RECRUITING

UC Davis Medical Center, Sacramento

97225

TERMINATED

Providence St. Vincent Medical Center, Portland

97239

TERMINATED

Oregon Health & Science University Hospital, Portland

98104

TERMINATED

Harborview Medical Center, Seattle

98122

RECRUITING

Swedish Medical Center - Cherry Hill Campus, Seattle

06102

RECRUITING

Hartford Hospital, Hartford

06520

RECRUITING

Yale New Haven Hospital, New Haven

02114

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Brigham and Women's Hospital, Boston

02118

RECRUITING

Boston Medical Center, Boston

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

01655

RECRUITING

UMass Memorial Medical Center, Worcester

08103

RECRUITING

Cooper University Hospital, Camden

07753

RECRUITING

Jersey Shore University Medical Center, Neptune City

07450

TERMINATED

Valley Hospital, Ridgewood

02903

RECRUITING

Rhode Island Hospital, Providence

05401

TERMINATED

The University of Vermont Medical Center, Burlington

L8L 8E7

WITHDRAWN

Hamilton General Hospital, Hamilton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

collaborator

University of Cincinnati

OTHER

collaborator

Medical University of South Carolina

OTHER

collaborator

Janssen Scientific Affairs, LLC

INDUSTRY

collaborator

AstraZeneca

INDUSTRY

lead

University of Florida

OTHER