DURvalumab in Combination With S-488210/S-488211 vAccine in Non-muscle Invasive Bladder CancEr

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

March 25, 2022

Primary Completion Date

May 31, 2025

Study Completion Date

May 31, 2029

Conditions
Bladder Cancer
Interventions
DRUG

Durvalumab

1500 mg IV infusion every 4 weeks for up to 7 doses

BIOLOGICAL

S-488210/S-488211

S-488210/S-488211 is given as a 1 mL subcutaneous (SC) injection of S-488210/Montanide emulsion and a 1 mL SC injection of S-488211/Montanide emulsion starting the day after first dose of durvalumab and continuing weekly for 6 doses and then every 2 weeks for a further 9 doses

Trial Locations (5)

Unknown

RECRUITING

Guy's and St Thomas' NHS Foundation Trust, London

RECRUITING

The Royal Marsden NHS Foundation Trust, London

RECRUITING

University College London Hospital NHS Foundation Trust, London

RECRUITING

The Christie NHS Foundation Trust, Manchester

RECRUITING

University Hospital Southampton NHS Foundation Trust, Southampton

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Shionogi

INDUSTRY

lead

University College, London

OTHER