Targeted Alpha Therapeutics for chemo-resistant Cancers
Total Trials
118
As Lead Sponsor
74
As Collaborator
44
Total Enrollment
15,001
NCT00023166
Phase I Study of PEG-Paclitaxel In Patients With Advanced Solid Tumors & Lymphomas
Phase: Phase 1
Role: Lead Sponsor
Start: May 31, 2001
Completion: May 31, 2002
NCT00890656
Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage
Phase: Phase 2
Role: Collaborator
Start: Jun 30, 2003
Completion: Jan 31, 2011
NCT00079950
Efficacy and Safety Evaluation of Pegamotecan (PEG-camptothecin) in Advanced or Metastatic Soft Tissue Sarcoma
Start: Aug 31, 2003
Completion: Not specified
NCT00080002
Efficacy of Pegamotecan (PEG-Camptothecin) in Localized or Metastatic Cancer of the Stomach or Gastroesophageal Junction
Start: Dec 31, 2003
NCT00177684
Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®)
Phase: Phase 3
Start: Sep 30, 2004
Completion: Sep 30, 2005
NCT00235651
Abelcet Radiotagging Protocol: Inhaled Lipid Complex Abelcet® in Lung Transplant Recipients
Start: Oct 31, 2005
Completion: Apr 30, 2006
NCT00515788
DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis
Start: Feb 28, 2006
Completion: Jun 30, 2009
NCT00329433
Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery
Phase: Phase 2/3
Start: May 31, 2006
Completion: Oct 31, 2008
NCT00523939
DepoCyt for Active Lymphomatous or Leukemic Meningitis
Start: Jun 30, 2006
NCT00363610
A Study Evaluating IV Oncaspar® and IV Gemzar® in the Treatment of Solid Tumors and Lymphoma
Start: Jul 31, 2006
Completion: Jun 30, 2008
NCT00388999
Intravenous rhMBL in Patients With Multiple Myeloma Receiving Chemotherapy Followed by Stem Cell Transplant
Start: Sep 30, 2006
Completion: May 31, 2009
NCT00886496
Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL Deficiency and Fever and Neutropenia
Start: Nov 30, 2006
Completion: Apr 30, 2011
NCT00415311
A Multicenter Study Evaluating the Safety and Tolerability of Intravenous rhMBL in Liver Transplant Recipients.
Start: Dec 31, 2006
Completion: Dec 31, 2009
NCT01656382
Safety, Efficacy, and Pharmacokinetics of Amphotericin B Lipid Complex
Phase: Phase 4
Start: Jan 31, 2007
Completion: Jan 31, 2010
NCT00466583
Phase 1 Study of EZN-2968 Weekly in Adult Patients With Advanced Solid Tumors or Lymphoma
Start: Mar 31, 2007
Completion: Jun 30, 2011
NCT00520390
A Phase I, Study to Evaluate the Safety and Tolerability of Intravenous EZN-2208 in Patients With Advanced Solid Tumors or Lymphoma (EZN-2208-02)
Start: May 31, 2007
NCT00520637
A Phase I, Study to Evaluate the Safety and Tolerability of Intravenous EZN-2208 in Patients With Advanced Solid Tumors or Lymphoma (EZN-2208-01)
NCT00520325
A Study of Safety, Tolerability, and Pk of rhMBL in Pediatric Hematology/Oncology Pts With Fever and Neutropenia
Start: Jun 30, 2007
Completion: Aug 31, 2009
NCT00549848
Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Start: Oct 29, 2007
Completion: Mar 26, 2022
NCT00614016
A Phase 1, Single-Dose Safety and Pharmacokinetic Study of Sodium ST20 in Healthy Volunteers
Start: Jan 31, 2008
NCT00717262
Phase 1 Placebo Controlled Study of the Safety, Activity and Pharmacokinetics of HQK-1001 in Healthy Subjects
Start: May 31, 2008
Completion: Sep 30, 2008
NCT00750737
Oral Posaconazole Three Times Per Day vs Weekly High Dose Amphotericin B Lipid Complex (ABLC)
Start: Jun 30, 2008
Completion: Jun 30, 2012
NCT00787332
A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome
Start: Sep 30, 2008
NCT00917826
Study of Arginine Butyrate and Ganciclovir/Valganciclovir in EBV(+) Lymphoid Malignancies
NCT00790127
Phase 1/2 Study of HQK-1001 in Patients With Beta Thalassemia
Phase: Phase 1/2
Start: Mar 31, 2009
Completion: May 31, 2010
NCT00842088
Phase 1/2 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HQK-1001 Administered Daily in Patients With Sickle Cell Disease
NCT00931840
A Study of EZN-2208 Administered With or Without Cetuximab in Patients With Metastatic Colorectal Carcinoma
Start: Jun 30, 2009
Completion: Jan 31, 2012
NCT00973752
Treatment of Older Adults With Acute Lymphoblastic Leukemia
Start: Aug 31, 2009
Completion: Apr 30, 2016
NCT01036113
A Phase 2 Study of EZN-2208 in Patients With Metastatic Breast Cancer
Start: Nov 30, 2009
Completion: Dec 31, 2012
NCT01295697
Study of EZN-2208 Pediatric Patients With Solid Tumors
Start: Feb 28, 2010
Completion: Jan 31, 2013
NCT00913133
Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis
Start: Mar 31, 2010
NCT00992732
Study of HQK-1004 and Valganciclovir to Treat Epstein-Barr Virus (EBV) - Positive Lymphoid Malignancies or Lymphoproliferative Disorders
Start: May 31, 2010
NCT01186328
EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)
Start: Aug 24, 2010
Completion: Jan 10, 2012
NCT01257542
Acute Cough Study In Children
Start: Dec 31, 2010
Completion: Mar 31, 2011
NCT01337518
A Phase 1a/1b Study to Evaluate the Safety of EZN-4176, in Adult Patients With Castration-Resistant Prostate Cancer
Start: Mar 31, 2011
Completion: Dec 31, 2013
NCT01322269
A Study of HQK-1001 in Patients With Sickle Cell Disease
Start: Apr 30, 2011
NCT01334827
A Formative Study to Explore the Sensory Perceptions of Vaginal Product Users
Phase: N/A
NCT01439126
Efficacy & Safety of KAPVAY™ Extended-Release in Children & Adolescents With Attention Deficit Hyperactivity Disorder
Start: Aug 31, 2011
Completion: Oct 31, 2012
NCT01642758
Trial of HQK-1001 in Beta Thalassemia Intermedia in Lebanon
Start: May 31, 2012
NCT01601340
Effects of HQK-1001 in Patients With Sickle Cell Disease
Start: Jul 31, 2012
NCT01733082
The Mycophenolate Pregnancy Registry
Start: Nov 20, 2012
Completion: Dec 31, 2025
NCT01984073
Effects of Niacin On Fatty Acid Trapping
Start: Dec 31, 2012
Completion: Dec 31, 2019
NCT01716000
Optical Imaging and User Perception Study of Vaginal Gel
Start: Jan 31, 2013
Completion: Nov 30, 2013
NCT01873534
A Phase 2A Trial of FMX-8 Treatment for Anemia in Patients With ESRD on Hemodialysis HD
Start: Jun 30, 2013
Completion: Mar 31, 2014
NCT02102867
Developing Rectal USPE Measures
Start: Apr 30, 2014
Completion: Apr 1, 2022
NCT02193958
Study of FF-10501-01 in Patients With Relapsed or Refractory Hematological Malignancies
Start: Jul 31, 2014
Completion: Oct 15, 2019
NCT02228655
An Exploratory Study to Evaluate FMX-8 to Treat Anemia in CKD
Phase: Early Phase 1
Start: Oct 31, 2014
Completion: Jul 31, 2015
NCT02454010
A Dose Escalation Study of Radio-labeled Antibody for the Treatment of Advanced Cancer
Start: Jan 31, 2016
Completion: Oct 31, 2021
NCT02661542
Study of FF-10502-01 in Patients With Advanced Solid Tumors and Lymphomas
Completion: Nov 5, 2020
NCT02744261
Developing Rectal USPE Measures for Suppositories (Project DRUM-S)
Start: Aug 11, 2016
NCT02960893
Trial in Adult Participants With Spinocerebellar Ataxia (SCA)
Start: Dec 15, 2016
Completion: Sep 20, 2024
NCT03017508
Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder
Start: Jan 31, 2017
Completion: Jan 29, 2021
NCT03194685
Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Start: May 5, 2017
Completion: Jul 31, 2021
NCT03082690
ImQuest (IQP) DuoGel Phase 1 Pharmacokinetic Study
Start: Nov 1, 2017
Completion: Jun 2, 2019
NCT03299166
Troriluzole (BHV-4157) in Adult Participants With Obsessive Compulsive Disorder
Start: Dec 19, 2017
Completion: Mar 31, 2026
NCT03520517
Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS
Start: Feb 2, 2018
Completion: Oct 8, 2018
NCT03440450
A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer
Start: Mar 22, 2018
NCT03605667
Study of BHV-4157 in Alzheimer's Disease
Start: Jul 31, 2018
Completion: Dec 23, 2021
NCT06824948
Evaluate the Safety, Tolerance, and Pharmacokinetic Profiles of Timolol Maleate Gel
Start: Oct 12, 2018
Completion: Dec 12, 2018
NCT03746431
A Phase 1 Study of [225Ac]-FPI-1434 Injection
Start: Jan 17, 2019
Completion: Jun 30, 2026
NCT03852251
A Study of AK104, a PD-1/CTLA-4 Bispecific Antibody, for Advanced Solid Tumors or With mXELOX/XELOX as First-line Therapy for Advanced Gastric or GEJ Adenocarcinoma
Start: Jan 18, 2019
Completion: Mar 25, 2024
NCT03829241
Randomized Trial of Adult Participants With Generalized Anxiety Disorder
Start: Feb 19, 2019
Completion: May 8, 2020
NCT03701399
Troriluzole in Adult Participants With Spinocerebellar Ataxia
Start: Mar 8, 2019
Completion: Oct 31, 2025
NCT03952806
Study of BHV-3241 in Participants With Multiple System Atrophy
Start: Jul 29, 2019
Completion: Jun 30, 2022
NCT03970447
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma
Start: Jul 30, 2019
Completion: Jun 30, 2030
NCT03486353
A Study of FF-10501-01 in Combination with Azacitidine in Patients with Myelodysplastic Syndrome
Start: Oct 1, 2019
Completion: Oct 1, 2019
NCT04047251
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma
Start: Nov 14, 2019
Completion: Jul 31, 2026
NCT04172454
Safety and Efficacy of AK104, a PD-1/CTLA-4 Bispecific Antibody, in Selected Advanced Solid Tumors
Start: Dec 20, 2019
Completion: Sep 23, 2022
NCT04358549
Study of the Use of Favipiravir in Hospitalized Subjects With COVID-19
Start: Apr 17, 2020
Completion: Oct 30, 2020
NCT04547101
A Study of AK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid Tumors
Start: Apr 24, 2020
Completion: Sep 30, 2022
NCT04220307
A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma
Start: Apr 26, 2020
Completion: Mar 9, 2023
NCT04444141
A Study of PD-1/CTLA-4 Bispecific AK104 in Relapsed or Refractory Peripheral T-cell Lymphoma
Start: May 15, 2020
NCT04444167
A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Plus Lenvatinib in First-line Advanced Hepatocellular Carcinoma
Start: Jul 7, 2020
Completion: Nov 20, 2023
NCT04436510
HEALEY ALS Platform Trial - Regimen B Verdiperstat
Start: Jul 28, 2020
Completion: Dec 6, 2022
NCT06677853
Timolol Maleate Gel for the Treatment of Infantile Hemangioma
Start: Oct 28, 2020
Completion: Jun 21, 2022
NCT04641143
Efficacy and Safety Study of Adjunctive Troriluzole in Obsessive Compulsive Disorder
Start: Dec 22, 2020
Completion: Nov 30, 2025
NCT04616456
Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients
Start: Dec 30, 2020
Completion: Jan 30, 2022
NCT04728321
A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Alone or in Combination With Lenvatinib in Advanced Hepatocellular Carcinoma
Start: Jan 27, 2021
Completion: Aug 2, 2023
NCT04693351
Efficacy and Safety Study of Adjunctive Troriluzule in Obsessive Compulsive Disorder
Start: Jan 29, 2021
Completion: Apr 29, 2025
NCT04711837
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
Start: Feb 11, 2021
Completion: Apr 20, 2022
NCT04708834
Long-term Safety Study of Adjunctive Troriluzole in Subjects With Obsessive Compulsive Disorder
Start: Mar 30, 2021
NCT04838639
Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Food Effect of NO-13065 in Healthy and Obese Adult Subjects
Start: Jun 14, 2021
Completion: Mar 31, 2022
NCT04899921
Troriluzole or Placebo Plus Ipi Plus Nivo in Mel Brain Mets
Start: Jun 30, 2021
Completion: May 29, 2023
NCT04634435
Autologous Memory-like NK Cell Therapy With BHV-1100 and Low Dose IL-2 in Multiple Myeloma Patients
Start: Oct 21, 2021
Completion: Jan 10, 2025
NCT05170763
Safety, Tolerability, and Pharmacokinetics of PA9159 Nasal Spray in Healthy Adult Subjects
Start: Nov 10, 2021
Completion: Jan 5, 2022
NCT05219500
Targeted Alpha Therapy With 225Actinium-Prostate Specific Membrane Antigen (PSMA)-I&T of Castration-resISTant Prostate Cancer (TATCIST).
Start: Dec 16, 2021
NCT05234580
Safety and Efficacy Study of PA9159 Nasal Spray for the Treatment of Seasonal Allergic Rhinitis
Start: Apr 15, 2022
Completion: Dec 25, 2022
NCT05363605
A Study of [225Ac]-FPI-1966 in Participants With Advanced Solid Tumours
Start: Apr 20, 2022
Completion: Sep 8, 2023
NCT05318573
A Study to Evaluate Safety, Efficacy of FF-10832 in Combo With Pembrolizumab in Urothelial & Non-small Cell Lung Cancer
Start: Jun 1, 2022
Completion: Nov 30, 2029
NCT05337553
A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With Spinal Muscular Atrophy
Start: Jul 6, 2022
Completion: Jan 31, 2026
NCT05478174
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
Start: Jul 26, 2022
Completion: Nov 14, 2023
NCT05614544
Dose-Finding and Human Abuse Potential Study Of HSK3486 Injection In Nondependent, Recreational Central Nervous System Depressant Users
Start: Aug 16, 2022
Completion: Oct 3, 2023
NCT05522894
AK104 Alone or in Combination With Chemotherapy in the First-line Treatment of ESCC
Start: Oct 1, 2022
Completion: Oct 1, 2024
NCT05947201
Neoadjuvant Treatment of Cadonilimab Combined Albumin-paclitaxel, Cisplatin and Fluorouracil for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Start: May 8, 2023
NCT04930354
ECP-1014 Treatment for Patients With Solid Tumor Cancers
Start: May 31, 2023
Completion: Dec 31, 2023
NCT05587374
Cadonilimab (PD-1/CTLA-4 Bispecific Blockade) and Chemoradiotherapy in Nasopharyngeal Carcinoma (GEMSTONE)
Start: Aug 1, 2023
Completion: Aug 1, 2029
NCT06001151
Cadonilimab (AK104) Plus Chemotherapy as First-line Treatment in Non-squamous Non-Small Cell Lung Cancer (NSCLC) Patients With Programmed Cell Death Ligand 1 (PD-L1) Negative
Start: Aug 7, 2023
Completion: Aug 31, 2027
NCT06277674
Efficacy of Cadonilimab in Non-squamous Non-small Cell Lung Cancer Patients Resistant to EGFR-TKI
Start: Nov 2, 2023
Completion: Jun 30, 2025
NCT05486416
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
Start: Jan 12, 2024
Completion: Jul 23, 2024
NCT06402331
FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Start: Mar 5, 2024
Completion: Jan 23, 2031
NCT06285916
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
Start: Mar 28, 2024
NCT06795204
Effects of HSK3486 on Cardiac Repolarization in Health Subjects (TQT)
Start: Apr 9, 2024
Completion: May 19, 2024
NCT06426797
Neoadjuvant Cadonilimab Combined With Anlotinib in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma
Start: May 31, 2024
Completion: May 31, 2027
NCT06813807
A Comparative Study of the Pharmacokinetic Profiles of Timolol Maleate Ophthalmic Gel With Timolol Maleate Gel
Start: Jun 15, 2024
Completion: Jul 5, 2024
NCT06916273
Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects
Start: Jul 22, 2024
Completion: Sep 21, 2024
NCT06147037
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
Start: Jul 31, 2024
Completion: Dec 30, 2027
NCT06714084
CNCMT:a Multi-center, Prospective, Single-arm Study
Start: Oct 8, 2024
Completion: Dec 31, 2026
NCT06552260
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Start: Feb 19, 2025
Completion: Aug 1, 2027
NCT06909825
FPI-2265 (225Ac-PSMA-I&T) and Olaparib for Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Start: Feb 26, 2025
Completion: Aug 12, 2030
NCT06940921
SBRT-LDRT-Cadonilimab for Advanced Gastric, Colorectal and Ovarian Cancers With Peritoneal Metastases
Start: Mar 20, 2025
Completion: Nov 30, 2027
NCT06575426
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Start: Jun 10, 2025
Completion: Jun 30, 2027
NCT06232083
A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)
Start: Sep 1, 2025
Completion: Sep 1, 2027
NCT07125261
BHV-7000 Responsive Neurostimulation System (RNS) Study
Start: Sep 30, 2025
Completion: Sep 30, 2026
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