Safety, Tolerability, and Pharmacokinetics of PA9159 Inhalation Aerosol in Healthy Adult Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 22, 2024

Primary Completion Date

September 12, 2024

Study Completion Date

September 21, 2024

Conditions
Bronchial Asthma
Interventions
DRUG

PA9159 Inhalation aerosol, 60 μg one day treatment

single dose of PA9159 (60 μg/inhaler spray) is administered by inhalation through an inhaler via the mouth, with 2 puffs.

DRUG

PA9159 Inhalation aerosol, 120 μg one day treatment

single dose of PA9159 (120 μg/inhaler spray) is administered by inhalation through an inhaler via the mouth, with 4 puffs.

DRUG

PA9159 Inhalation aerosol, 240 μg one day treatment

single dose of PA9159 (240 μg/inhaler spray) is administered by inhalation through an inhaler via the mouth, with 8 puffs.

DRUG

PA9159 Inhalation aerosol, 300 μg one day treatment

single dose of PA9159 (300 μg/inhaler spray) is administered by inhalation through an inhaler via the mouth, with 10 puffs.

DRUG

PA9159 Inhalation aerosol, 120 μg 7-day treatment

Repeated doses of PA9159 (120 μg/inhaler spray) i is administered by inhalation through an inhaler via the mouth, with 4 puffs, twice a day.

DRUG

Placebo, the same Inhalation aerosol solution without PA9159 active ingredient

Placebo is delivered via the mouth through an inhaler with the same volume as the corresponding PA9159 dose group

Trial Locations (1)

330006

The First Affiliated Hospital of Nanchang University, Nanchang

All Listed Sponsors
lead

Anhui Palo Alto Pharmaceuticals, Inc.

INDUSTRY