Effects of Niacin On Fatty Acid Trapping

PHASE1CompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

December 31, 2019

Study Completion Date

December 31, 2019

Conditions
Dyslipidemia
Interventions
DRUG

ER Niacin Oral Fat Challenge

Extended release niacin 2000 mg at hour 0, followed by oral fat challenge at hour 1.

DRUG

IR Niacin Oral Fat Challenge

Nialor(R) 500mg or Placebo at hour 0, 2, 4, and 6. Oral fat challenge at hour 1 (one hour after first dose of immediate-release niacin)

OTHER

Placebo Oral Fat Challenge

Placebo at hour 0. Oral fat challenge at hour 1, followed by placebo at hours 2,4,and 6

Trial Locations (2)

19104

Hospital of the University of Pennsylvania, Philadelphia

Presbyterian Hospital, Philadelphia

Sponsors
All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Arizona Pharmaceuticals Inc.

INDUSTRY

lead

University of Pennsylvania

OTHER