490
Participants
Start Date
August 1, 2023
Primary Completion Date
August 1, 2027
Study Completion Date
August 1, 2029
Cadonilimab
Cadonilimab 10mg/kg will be given every 3 weeks for 3 cycles in induction chemotherapy and for 14 cycles in adjuvant chemotherapy, started on day 1 of induction chemotherapy and adjuvant chemotherapy, respectively.
Gemcitabine
Gemcitabine 1g/m2, d1 \& 8 of every cycle, every 3 weeks for 3 cycles before radiation.
Cisplatin
Induction cisplatin 80mg/m2, every 3 weeks for 3 cycles before radiation; Concurrent cisplatin 100mg/m2, every 3 weeks for 2 cycles during radiation
Intensity-modulated radiotherapy
Definitive intensity-modulated radiotherapy (IMRT) of 6996cGy will be given in 33 fractions.
The First Affiliated Hospital of University of Science and Technology of China, Hefei
The First Affiliated Hospital of Bengbu Medical College, Bengbu
Hunan Cancer Hospital, Changsha
Renmin Hospital of Wuhan University, Wuhan
Zhongnan Hospital of Wuhan University, Wuhan
Sun Yat-Sen University Cancer Center, Guangzhou
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
Fujian Cancer Hospital, Fuzhou
Dongguan Peaple's Hospital, Dongguan
Zhongshan city Peaple's Hospital, Zhongshan
Cancer Hospital of Guangxi Medical University, Nanning
Cancer Hospital of Guizhou Medical University, Guiyang
Hubei Province Cancer Hosiptal, Wuhan
Tongji Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan
Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan
Xiangya Hospital Central South University, Changsha
Shandong Province Cancer Hospital, Jinan
Changhai Hospital of Shanghai, Shanghai
Collaborators (1)
Akeso Pharmaceuticals, Inc.
OTHER
Sun Yat-sen University
OTHER