Small Molecules, Biologics, Vaccines
Total Trials
66
As Lead Sponsor
42
As Collaborator
24
Total Enrollment
5,862
NCT00709462
A Study of CDX-1307, in Patients With Incurable Breast, Colorectal, Pancreatic, Ovarian or Bladder Cancer (CDX 1307-01)
Phase: Phase 1
Role: Lead Sponsor
Start: Mar 31, 2004
Completion: Jun 30, 2010
NCT00648102
Phase I Study of CDX-1307, hCG-B Vaccine, for Patients With Incurable, Locally Advanced or Metastatic Breast, Colorectal, Pancreatic, Bladder or Ovarian Cancer
Start: Jan 31, 2006
Completion: Dec 31, 2009
NCT00458601
Phase II Study of Rindopepimut (CDX-110) in Patients With Glioblastoma Multiforme
Phase: Phase 2
Start: Aug 31, 2007
Completion: May 31, 2016
NCT00948961
A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1
Phase: Phase 1/2
Start: Sep 30, 2009
Completion: Feb 28, 2014
NCT01094496
"A Study of the CDX-1307 Vaccine Regimen in Patients With Newly Diagnosed Muscle-Invasive Bladder Cancer (The N-ABLE Study)"
Start: Apr 30, 2010
Completion: Jul 31, 2011
NCT01156753
A Study of CDX-011 (CR011-vcMMAE) in Patients With Advanced GPNMB-expressing Breast Cancer
Start: Jul 31, 2010
Completion: Nov 30, 2012
NCT01460134
A Study of CDX-1127 (Varlilumab) in Patients With Select Solid Tumor Types or Hematologic Cancers
Start: Oct 31, 2011
Completion: Oct 16, 2017
NCT01465139
A Study to Evaluate CDX-301 (rhuFlt3L) in Healthy Volunteers
Completion: Jan 31, 2013
NCT01480479
Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma
Phase: Phase 3
Start: Nov 30, 2011
Completion: Nov 30, 2016
NCT01498328
A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma
Start: Dec 31, 2011
Completion: May 17, 2016
NCT01791686
Clinical Trial of CDX-1135 in Pediatric and Adult Patients With Dense Deposit Disease
Start: Jan 31, 2013
Completion: Mar 31, 2014
NCT01997333
Study of Glembatumumab Vedotin (CDX-011) in Patients With Metastatic, gpNMB Over-Expressing, Triple Negative Breast Cancer
Start: Nov 30, 2013
Completion: Aug 7, 2018
NCT01976585
In Situ Vaccine for Low-Grade Lymphoma: Combination of Intratumoral Flt3L and Poly-ICLC With Low-Dose Radiotherapy
Role: Collaborator
Start: Jan 3, 2014
Completion: Nov 20, 2020
NCT02014909
A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of KTN3379 in Adult Subjects With Advanced Tumors
Start: Jan 31, 2014
Completion: Jun 5, 2017
NCT02200380
A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs
Start: Jul 31, 2014
Completion: Apr 13, 2016
NCT02166905
DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, and IDO1 Inhibitor INCB024360 in Treating Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer in Remission
Start: Oct 10, 2014
Completion: Aug 20, 2020
NCT02302339
A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma
Start: Nov 30, 2014
Completion: Oct 3, 2018
NCT02270372
Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer
Completion: Jun 30, 2016
NCT02284971
Pilot Study of SBRT and CDX-1127 in Prostate Cancer
Completion: Apr 7, 2016
NCT02335918
A Dose Escalation and Cohort Expansion Study of Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab) in Advanced Refractory Solid Tumors
Start: Jan 31, 2015
Completion: Dec 12, 2018
NCT02413827
A Study of Varlilumab (Anti-CD27) and Ipilimumab and CDX-1401 in Patients With Unresectable Stage III or IV Melanoma
Start: Apr 30, 2015
Completion: Nov 9, 2016
NCT02386111
A Study of Varlilumab (Anti-CD27) and Sunitinib in Patients With Metastatic Clear Cell Renal Cell Carcinoma
Start: May 31, 2015
Completion: Nov 3, 2017
NCT02456701
Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379
Start: Jun 30, 2015
Completion: Oct 13, 2016
NCT02473731
A Window of Opportunity Study of KTN3379 in Surgically Resectable Head and Neck Cancer Patients
Start: Oct 31, 2015
Completion: Oct 10, 2016
NCT02543645
A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer
Completion: May 22, 2017
NCT02642016
A Study to Evaluate the Safety and Pharmacokinetics of CDX-0158 in Adult Patients With Advanced Solid Tumors
Start: Dec 31, 2015
Completion: Jun 4, 2019
NCT02713828
Study of Glembatumumab Vedotin in gpNMB-Expressing, Advanced or Metastatic SCC of the Lung
Start: Apr 10, 2016
Completion: Sep 26, 2018
NCT02837991
A Dose Escalation, Safety and Activity Study of CDX-014 in Patients With Renal Cell Carcinoma and Ovarian Clear Cell Carcinoma
Start: Jun 30, 2016
Completion: Nov 16, 2018
NCT02839265
FLT3 Ligand Immunotherapy and Stereotactic Radiotherapy for Advanced Non-small Cell Lung Cancer
Start: Jul 31, 2016
Completion: Nov 22, 2024
NCT02924038
A Study of Varlilumab and IMA950 Vaccine Plus Poly-ICLC in Patients With WHO Grade II Low-Grade Glioma (LGG)
Start: Apr 3, 2017
Completion: Dec 31, 2022
NCT03307746
A Combination of Rituximab and Varlilumab Immunotherapy in Patients with B-cell Lymphoma
Start: Nov 23, 2017
Completion: Aug 21, 2024
NCT03329950
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies
Start: Dec 1, 2017
Completion: Sep 13, 2022
NCT03254927
A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma
Start: Mar 27, 2018
Completion: Dec 16, 2020
NCT03358719
DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia
Completion: Aug 25, 2021
NCT03473691
Pilot Study of Glembatumumab Vedotin Following Doxorubicin and Cytoxan as Neo-adjuvant Therapy in Gp-NMB-expressing High Risk Triple Negative Breast Cancer
Phase: Early Phase 1
Start: May 1, 2018
Completion: May 1, 2018
NCT03580382
Study of CDX-3379, a Human Monoclonal Antibody Targeting ERBB3, in Combination With the MEK Inhibitor, Trametinib, in Patients With Advanced Stage NRAS Mutant and BRAF/NRAS Wildtype (WT) Melanoma
Start: Jul 6, 2018
NCT03617328
Vaccination With 6MHP, With or Without Systemic CDX-1127, in Patients With Stage II-IV Melanoma
Start: Nov 13, 2018
Completion: Jan 19, 2024
NCT03789097
Vaccination With Flt3L, Radiation, and Poly-ICLC
Start: Apr 5, 2019
Completion: Mar 31, 2025
NCT03835533
Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel Combinations
Start: Jun 21, 2019
Completion: Oct 3, 2022
NCT04146129
A Phase 1 Study of CDX-0159
Start: Oct 29, 2019
Completion: Jun 26, 2020
NCT03804944
Converting HR+ Breast Cancer Into an Individualized Vaccine
Start: Mar 17, 2020
Completion: Dec 31, 2027
NCT04440943
A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies
Start: Aug 4, 2020
Completion: Apr 6, 2023
NCT03688178
DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab
Start: Aug 26, 2020
Completion: Mar 31, 2026
NCT04538794
A Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria
Start: Sep 24, 2020
Completion: Jan 17, 2023
NCT04364230
Melanoma Vaccine Against Neoantigen and Shared Antigens by CD40 Activation and TLR Agonists In Patients With Melanoma (Including Ocular Melanoma)
Start: Sep 28, 2020
Completion: Mar 14, 2024
NCT04548869
A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of CDX-0159 in Patients With Cold Contact Urticaria, Symptomatic Dermographism, or Cholinergic Urticaria
Start: Nov 24, 2020
Completion: May 12, 2023
NCT04491084
FLT3 Ligand, CD40 Agonist Antibody, and Stereotactic Radiotherapy
Start: Jan 1, 2021
Completion: Aug 18, 2022
NCT04536077
Immunologic Effects of CDX-301 and CDX-1140 in Resectable Pancreatic Cancer Patients
Start: Aug 13, 2021
Completion: Nov 21, 2023
NCT05031624
A Phase 1 Study of Subcutaneous CDX-0159 in Healthy Subjects
Start: Aug 30, 2021
Completion: Jan 14, 2022
NCT04944862
A Study of CDX-0159 in Patients With Prurigo Nodularis
Start: Nov 8, 2021
Completion: Jul 31, 2023
NCT04930783
NeoVax + CDX-301 and Nivolumab or Pembrolizumab in Melanoma
Start: Jan 3, 2022
Completion: Sep 30, 2030
NCT05029999
CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer
Start: Apr 20, 2022
Completion: Apr 20, 2026
NCT05368285
A Phase 2 Study of CDX-0159 in Patients With Chronic Spontaneous Urticaria
Start: May 19, 2022
Completion: Dec 20, 2024
NCT05405660
A Study of CDX-0159 in Patients With Chronic Inducible Urticaria
Start: Jun 28, 2022
Completion: Sep 30, 2025
NCT05484011
A Maintenance Therapy Study of Odetiglucan With CDX-1140 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Start: Dec 15, 2022
Completion: Mar 4, 2024
NCT05349890
Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)
Start: Apr 3, 2023
Completion: Apr 15, 2028
NCT05788484
A Study of CDX-585 in Patients With Advanced Malignancies
Start: May 11, 2023
Completion: May 21, 2025
NCT05774184
A Study of CDX-0159 in Patients With Eosinophilic Esophagitis
Start: Jun 1, 2023
Completion: Dec 31, 2025
NCT05231122
Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer
Start: Mar 12, 2024
Completion: Dec 30, 2026
NCT06366750
A Study of Barzolvolimab in Patients With Prurigo Nodularis
Start: Apr 12, 2024
Completion: Jun 30, 2026
NCT06445023
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
Start: Jul 11, 2024
Completion: Apr 30, 2027
NCT06455202
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
Start: Jul 19, 2024
NCT06650761
A Phase I Study of CDX-622
Start: Nov 1, 2024
Completion: Apr 30, 2026
NCT06727552
A Study of Barzolvolimab in Patients With Atopic Dermatitis
Start: Jan 7, 2025
Completion: May 31, 2027
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