A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

September 30, 2009

Primary Completion Date

June 30, 2012

Study Completion Date

February 28, 2014

Conditions
Advanced Malignancies
Interventions
BIOLOGICAL

CDX-1401 in combination with Resiquimod and/or Poly-ICLC

CDX-1401 is administered as an injection into the skin every 2 weeks for 4 doses. It is given in combination with Resiquimod and/or poly-ICLC. Resiquimod is administered as a topical gel applied to the skin or given as an injection under the skin, and poly-ICLC is given as an injection under the skin. Depending on the treatment group assignment, either one or both of the immune stimulants will be given on the day of and the day after CDX-1401 administrations. This treatment may be repeated every 12 weeks.

BIOLOGICAL

CDX-1401

BIOLOGICAL

Resiquimod

BIOLOGICAL

poly-ICLC

Trial Locations (7)

10017

Memorial Sloan Kettering Cancer Center, New York

10065

Weill Cornell Cancer Center, New York

28078

Carolina BioOncology Institute, PLLC, Huntersville

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

48202

Henry Ford Health System, Detroit

97213

Providence Portland Cancer Center, Portland

06519-1717

Yale Comprehensive Cancer Center, New Haven

Sponsors
All Listed Sponsors
lead

Celldex Therapeutics

INDUSTRY

NCT00948961 - A Study of CDX-1401 in Patients With Malignancies Known to Express NY-ESO-1 | Biotech Hunter | Biotech Hunter