Vaccination With Flt3L, Radiation, and Poly-ICLC

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

April 5, 2019

Primary Completion Date

March 31, 2025

Study Completion Date

March 31, 2025

Conditions
Non-Hodgkin's LymphomaMetastatic Breast CancerHead and Neck Squamous Cell Carcinoma
Interventions
DRUG

Pembrolizumab

200 mg administered as an IV infusion over 30 minutes Q3W

DRUG

Flt3L

an immune cell growth factor. CDX-301 drug product is formulated as a sterile solution intended for single-use parenteral administration. Each vial contains a nominal 2.5 mg/mL CDX-301 protein in a 1 mL volume of buffered solution composed of sodium phosphate and sodium chloride, with a pH of 7.0.

RADIATION

Radiation

The target site will get 2 small treatments of radiation.

DRUG

Poly ICLC

an immune cell activating factor. vials containing 1 ml of 2 mg/mL

Trial Locations (1)

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Celldex Therapeutics

INDUSTRY

lead

Icahn School of Medicine at Mount Sinai

OTHER

NCT03789097 - Vaccination With Flt3L, Radiation, and Poly-ICLC | Biotech Hunter | Biotech Hunter