CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 20, 2022

Primary Completion Date

April 20, 2026

Study Completion Date

April 20, 2026

Conditions
HER2-negative Breast CancerMetastatic Breast Cancer
Interventions
DRUG

PLD Chemotherapy

PLD chemotherapy will be administered 40 mg/m2 as intravenous injection once per cycle.

DRUG

CDX-1140

CDX-1140 will be administered 1.5mg/kg as intravenous injection once per cycle.

DRUG

CDX-301

CDX-301 will be administered 75µg/kg as subcutaneous injection daily x 5 doses per cycle for 2 cycles.

Trial Locations (7)

21287

RECRUITING

Johns Hopkins University, Baltimore

27599

RECRUITING

University of North Carolina, Chapel Hill

37203

WITHDRAWN

Sarah Cannon Research Institute, Nashville

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

75251

ACTIVE_NOT_RECRUITING

Texas Oncology, P.A., Dallas

75390

RECRUITING

UT Southwestern Medical Center, Dallas

78229

RECRUITING

The University of Texas Health Science Center at San Antonio, San Antonio

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celldex Therapeutics

INDUSTRY

collaborator

Gateway for Cancer Research

OTHER

collaborator

National Institutes of Health (NIH)

NIH

lead

University of Texas Southwestern Medical Center

OTHER

NCT05029999 - CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer | Biotech Hunter | Biotech Hunter