A Study of CDX-011 (CR011-vcMMAE) in Patients With Advanced GPNMB-expressing Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 31, 2010

Primary Completion Date

October 31, 2012

Study Completion Date

November 30, 2012

Conditions
Breast Cancer
Interventions
DRUG

CDX-011

CDX-011 (1.88 mg/kg) administered as an intravenous infusion on Day 1 of each 21 day cycle.

DRUG

"Investigator's Choice chemotherapy"

Any of the following single-agent chemotherapy may be given at the discretion of the investigator, with a cycle length not to exceed four weeks: Capecitabine, Vinorelbine, Gemcitabine, Docetaxel, Paclitaxel, Albumin-bound paclitaxel, Doxorubicin HCL, Liposomal doxorubicin, Ixabepilone and Eribulin.

Trial Locations (24)

10065

Weill Cornell Breast Center/Weill Cornell Medical College, New York

10467

Montefiore-Einstein Cancer Center, The Bronx

11042

Clinical Research Alliance Inc., Lake Success

18840

Guthrie Clinic, Ltd., Sayre

28203

Levine Cancer Institute/Blumenthal Cancer Center, Charlotte

29150

Santee Hematology Oncology, Inc., Sumter

29210

South Carolina Oncology Associates, Columbia

30318

Peachtree Hematology-Oncology Consultants PC, Atlanta

30341

Georgia Cancer Specialists, Atlanta

35294

The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham

37203

Sarah Cannon Research Institution, Nashville

37909

Center for Biomedical Research, Knoxville

45242

Oncology Hematology Care, Cincinnati

48202

Henry Ford Health System, Detroit

59802

Montana Cancer Institute Foundation, Missoula

60076

Orchard Healthcare Research Inc., Skokie

60099

Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion

70115

Cancer Care of Louisiana, New Orleans

85724

Arizona Cancer Center, Tucson

90025

The Angeles Clinic and Research Institute, Los Angeles

90033

USC/Norris Comprehensive Cancer Center, Los Angeles

90806

Breastlink Medical Group, Long Beach

94143

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

Unknown

Florida Cancer Specialists, West Coast

Sponsors
All Listed Sponsors
lead

Celldex Therapeutics

INDUSTRY

NCT01156753 - A Study of CDX-011 (CR011-vcMMAE) in Patients With Advanced GPNMB-expressing Breast Cancer | Biotech Hunter | Biotech Hunter