A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer

PHASE1TerminatedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

October 31, 2015

Primary Completion Date

April 30, 2017

Study Completion Date

May 22, 2017

Conditions
Carcinoma, Renal CellKidney DiseasesKidney NeoplasmsUrogenital NeoplasmsUrologic DiseasesUrologic NeoplasmsNeoplasms by Histologic TypeNeoplasmsClear-cell Metastatic Renal Cell CarcinomaMelanomaTriple Negative Breast CancerBladder CancerHead and Neck CancerNon-small Cell Lung Cancer
Interventions
DRUG

Combination of Varlilumab and Atezolizumab

"Treatment cycles are 12 weeks each with varlilumab and atezolizumab administered every 3 weeks. During the treatment phase of the study, eligible patients will receive varlilumab for up to 3 cycles (with a 4th cycle possible following discussion with the Medical Monitor). There is no limit on the number of cycles of atezolizumab. Patients may be discontinued from receiving study treatment (atezolizumab or varlilumab) based on the results of disease assessments or if experiencing side effects that make study therapy intolerable.~Phase l Dose: The planned dose of varlilumab will be dependent on the cohort assigned at enrollment. Varlilumab doses are 0.3 mg/kg, 1 mg/kg, or 3 mg/kg. The dose of atezolizumab is 1200 mg."

Trial Locations (4)

10065

Memorial Sloan Kettering Cancer Center, New York

27710

Duke University Medical Center, Durham

94550

University of California - San Francisco, San Francisco

02215

Beth Israel Deaconess Medical Center, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Celldex Therapeutics

INDUSTRY