18
Participants
Start Date
October 31, 2015
Primary Completion Date
April 30, 2017
Study Completion Date
May 22, 2017
Combination of Varlilumab and Atezolizumab
"Treatment cycles are 12 weeks each with varlilumab and atezolizumab administered every 3 weeks. During the treatment phase of the study, eligible patients will receive varlilumab for up to 3 cycles (with a 4th cycle possible following discussion with the Medical Monitor). There is no limit on the number of cycles of atezolizumab. Patients may be discontinued from receiving study treatment (atezolizumab or varlilumab) based on the results of disease assessments or if experiencing side effects that make study therapy intolerable.~Phase l Dose: The planned dose of varlilumab will be dependent on the cohort assigned at enrollment. Varlilumab doses are 0.3 mg/kg, 1 mg/kg, or 3 mg/kg. The dose of atezolizumab is 1200 mg."
Memorial Sloan Kettering Cancer Center, New York
Duke University Medical Center, Durham
University of California - San Francisco, San Francisco
Beth Israel Deaconess Medical Center, Boston
Lead Sponsor
Collaborators (1)
Genentech, Inc.
INDUSTRY
Celldex Therapeutics
INDUSTRY