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Clinical Trials for Karyopharm Therapeutics
Explore 23 clinical trials worldwide
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Showing 1-23 of 23 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Karyopharm Therapeutics
Clinical Trials (23)
NCT07200102
Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma
PHASE1
Not yet recruiting
20 participants
Started: Dec 31, 2025 · Completed: Dec 31, 2030
1 condition
2 sponsors
1 location
NCT06399640
Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia
PHASE1
Recruiting
60 participants
Started: Aug 14, 2024 · Completed: Oct 1, 2027
5 conditions
3 sponsors
1 location
NCT05980806
A Study of Selinexor Monotherapy in Subjects with JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
PHASE2
Recruiting
118 participants
Started: Apr 22, 2024 · Completed: Oct 31, 2028
2 conditions
1 sponsor
48 locations
NCT05983276
Decitabine and Selinexor in Combination to Reverse Drug Resistance With Standard Chemotherapy in Ovarian Cancer
PHASE2
Recruiting
40 participants
Started: Nov 16, 2023 · Completed: Aug 28, 2031
1 condition
2 sponsors
1 location
NCT05597345
Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myeloma
PHASE2
Recruiting
15 participants
Started: Aug 21, 2023 · Completed: Dec 31, 2025
1 condition
2 sponsors
1 location
NCT05611931
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
PHASE3
Recruiting
276 participants
Started: Apr 18, 2023 · Completed: Jan 31, 2028
1 condition
13 sponsors
220 locations
NCT05530421
Selinexor, Venetoclax, and Dexamethasone (XVenD) in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma
PHASE2
Recruiting
33 participants
Started: Mar 26, 2023 · Completed: Mar 26, 2028
1 condition
2 sponsors
3 locations
NCT05028348
A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma
PHASE3
Recruiting
222 participants
Started: Apr 19, 2022 · Completed: Mar 31, 2029
1 condition
2 sponsors
94 locations
NCT04925193
Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma
PHASE2
Active, not recruiting
18 participants
Started: Nov 18, 2021 · Completed: Nov 30, 2026
1 condition
3 sponsors
1 location
NCT04898894
Study of Selinexor and Venetoclax in Combination With Chemotherapy in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
PHASE1
Active, not recruiting
37 participants
Started: Nov 15, 2021 · Completed: Feb 28, 2026
4 conditions
4 sponsors
8 locations
NCT04782687
Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
PHASE2
Active, not recruiting
73 participants
Started: Sep 10, 2021 · Completed: May 31, 2026
7 conditions
2 sponsors
10 locations
NCT04914845
KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia
PHASE1
Active, not recruiting
40 participants
Started: Aug 27, 2021 · Completed: Feb 8, 2027
3 conditions
2 sponsors
1 location
NCT04717700
Selinexor With Alternating Bortezomib or Lenalidomide Plus Dexamethasone in TIE Newly Diagnosed MM Patients
PHASE2
Active, not recruiting
50 participants
Started: Aug 18, 2021 · Completed: Jun 1, 2029
1 condition
3 sponsors
11 locations
NCT04562870
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
PHASE2
Active, not recruiting
112 participants
Started: Mar 17, 2021 · Completed: Sep 30, 2026
1 condition
1 sponsor
21 locations
NCT04562389
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
PHASE3
Active, not recruiting
353 participants
Started: Mar 11, 2021 · Completed: Mar 31, 2028
1 condition
1 sponsor
166 locations
NCT04519476
Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.
PHASE1
Recruiting
22 participants
Started: Nov 1, 2020 · Completed: Dec 29, 2023
1 condition
2 sponsors
1 location
NCT04442022
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
PHASE2/PHASE3
Recruiting
501 participants
Started: Sep 3, 2020 · Completed: Dec 31, 2025
1 condition
1 sponsor
57 locations
NCT04414475
A Study of Selinexor (Seli) + Low-dose Dexamethasone (LDD) in Penta-refractory Multiple Myeloma (MM), Seli and Bortezomib + LDD in Triple-class Refractory MM.
PHASE2
Recruiting
127 participants
Started: Jul 1, 2020 · Completed: Jan 31, 2028
1 condition
1 sponsor
17 locations
NCT03555422
Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]
PHASE3
Active, not recruiting
263 participants
Started: Jan 5, 2018 · Completed: Dec 31, 2025
1 condition
8 sponsors
78 locations
NCT02343042
Selinexor and Backbone Treatments of Multiple Myeloma Patients
PHASE1/PHASE2
Recruiting
300 participants
Started: Oct 31, 2015 · Completed: Apr 30, 2027
1 condition
2 sponsors
24 locations
NCT02436707
Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma
PHASE2
Active, not recruiting
129 participants
Started: Oct 27, 2015 · Completed: Dec 31, 2026
1 condition
4 sponsors
12 locations
NCT02227251
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
PHASE2
Recruiting
244 participants
Started: Nov 30, 2014 · Completed: Nov 30, 2027
1 condition
1 sponsor
176 locations
NCT02091245
Phase I Trial of the Selective Inhibitor of Nuclear Export, KPT-330, in Relapsed Childhood ALL and AML
PHASE1
Active, not recruiting
16 participants
Started: Mar 31, 2014 · Completed: Dec 31, 2025
9 conditions
3 sponsors
10 locations