A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

March 17, 2021

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2026

Conditions
Myelofibrosis
Interventions
DRUG

Selinexor

Unit Dose Strength: 20 mg; Dose Formulation: Tablet; Dosage Level: 60 or 80 mg, QW; Route of Administration: Oral

OTHER

Physician's Choice Treatment

Physician's choice treatment may include ruxolitinib retreatment, fedratinib, chemotherapy (e.g., hydroxyurea), anagrelide, corticosteroid, hematopoietic growth factor, immunomodulatory agent, androgen, interferon (all as per clinical practice) and may include supportive care only with no MF treatment; no investigational therapies are allowed.

Trial Locations (21)

4100

Azienda Unita Sanitaria Locale Latina - Ospedale Santa Maria Goretti, Latina

6132

University of Perugia Department of Medicine Hematology Section, Perugia

12462

"University General Hospital ATTIKON", Athens

21100

Asst Settelaghi, Ospedale Di Circolo E Fondazione Macchi, Varese

28041

Hospital Universitario 12 de Octubre, Madrid

29609

Institut de Cancéro-Hématologie, Brest

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola

49933

Centre Hospitalier Universitaire d'Angers (CHU Angers), Angers

50134

Università degli Studi di Firenze - Azienda Ospedaliero - Universitaria Careggi - Dipartimento di medicina sperimentale e clinica, Florence

60714

Illinois Cancer Specialist, Niles

75702

Texas Oncology - Northeast Texas, Tyler

80012

Rocky Mountain Cancer Centers, LLP, Aurora

91105

The Oncology Institute of Hope and Innovation, Pasadena

100730

Peking Union Medical College Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

215004

The Second Affiliated Hospital of Soochow University, Suzhou

215007

Suzhou University -The First Affiliated Hospital, Suzhou

226001

Affiliated Hospital of Nantong University, Nantong

310016

Sir Run Run Shaw Hospital - Zhejiang University School of Medicine, Hangzhou

430022

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

40-519

Pratia Onkologia Katowice, Katowice

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY