Maintenance with Selinexor/Placebo After Combination Chemotherapy in Participants with Endometrial Cancer [SIENDO]

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

263

Participants

Timeline

Start Date

January 5, 2018

Primary Completion Date

January 22, 2022

Study Completion Date

December 31, 2025

Conditions
Endometrial Cancer
Interventions
DRUG

Selinexor

Dose: 80 mg (4 tablets) or 60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

DRUG

Matching placebo for selinexor

Dose: 80 mg (4 tablets) or 60 mg (3 tablets); Dosage form: film-coated, immediate-release tablet of 20 mg each; Route of administration: oral

Trial Locations (78)

2300

AZ Turnhout, Turnhout

3000

Universitaire Ziekenhuizen K.U. Leuven, Leuven

4800

CHR Verviers, Verviers

5000

CHU UCL Namur, Site Sainte-Elisabeth, Namur

8900

Jan Yperman Ziekenhuis, Ieper

9000

UZ Gent, Ghent

10016

NYU Langone, New York

10034

UH Královské Vinohrady, Prague

10060

Istituto di Candiolo, FPO, IRCCS, Candiolo

10065

Memorial Sloan Kettering Cancer Center, New York

11528

ALEXANDRA Hospital, Athens

12851

General University Hospital in Prague, Prague

13353

Charite Berlin Universitatsmedizin, Berlin

18081

Hospital Na Bulovce, Prague

20014

Hospital Universitario Donostia, San Sebastián

20132

San Raffaele Hospital, Milan

20133

Istituto Nazionale dei Tumori IRCCS - MILANO S.C. Ginecologia Oncologica, Milan

23298

VCU Massey Cancer Center, Richmond

24105

Universitatsklinikum Schleswig-Holstein, Kiel

28034

Hospital Universitario Ramón y Cajal, Madrid

28220

Hospital Universitario Puerta de Hierro - Majadahonda, Madrid

28702

Hospital Universitario Infanta Sofía, Madrid

30120

Virgen de la Arrixaca University Clinical Hospital, Murcia

30161

Agostino Gemelli University Polyclinic Foundation, Rome

30171

DIAKOVERE KH gGmbH, Henriettenstift Hannover, Hanover

30174

ULSS 3 SERENISSIMA UOC Oncologia Ed Ematologia Oncologica, Mirano

33401

Florida Cancer Specialists (Sarah Cannon Research Institute), West Palm Beach

33612

Moffitt Cancer Center, Tampa

37203

Tennessee Oncology Nashville (Sarah Cannon Research Institute), Nashville

38100

Hillel Yaffe Medical Center, Hadera

41013

Hospital Universitario Virgen del Rocío, Seville

46009

Instituto Valenciano de Oncología, Valencia

46010

Hospital Clínico Universitario de Valencia, Valencia

46026

Hospital Universitario y Politécnico de La Fe, Valencia

46202

Indiana University Simon Cancer Center, Indianapolis

46845

Parkview Research Center, Fort Wayne

47014

Romagnolo Scientific Institute for the Study and Treatment of Tumors, Meldola

50009

Hospital Clínico Universitario Lozano Blesa, Zaragoza

52621

Sheba Medical Center, Ramat Gan

54645

Euromedica General Clinic, Thessaloniki

55131

Universitätsfrauenklinik Mainz, Mainz

58100

Wolfson Medical Center, Holon

60200

University Hospital Brno, Brno

60453

Gynecological Cancer Institute of Chicago, Oak Lawn

64132

HCA Midwest Health - Kansas City (Sarah Cannon Research Institute), Kansas City

66113

Cartitas Klinikum Saarbrücken, Saarbrücken

70852

University Hospital Ostrava, Ostrava

73104

University of Oklahoma Health Sciences Center - Stephenson Cancer Center, Oklahoma City

75246

Texas Oncology DFW, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

76104

Texas Oncology DFW, Fort Worth

78731

Texas Oncology, Austin, Austin

80131

"Istituto Nazionale Tumori IRCCS Fondazione G. Pascale - NAPOLI Struttura Complessa Oncologia Medica Uro-Ginecologica", Naples

80337

Klinikum der Universitat Munchen, Munich

85711

Arizona Oncology, Tucson

89070

Universitätsfrauenklinik Ulm, Ulm

94304

Stanford University, Palo Alto

97401

Oncology Associates of Oregon, Eugene

100730

Peking Union Medical College Hospital, Beijing

110042

Liaoning Cancer Hospital, Shenyang

150040

Harbin Medical University Cancer Hospital, Harbin

325000

Wenzhou Medical University - The First Affiliated Hospital, Wenzhou

330006

Jiangxi Maternal and Child Health Hospital, Nanchang

400000

Chongqing University Cancer Hospital, Chongqing

9103102

Shaare Zedek Medical Center, Jerusalem

9112001

Hadassah Medical Center, Jerusalem

02905

Women & Infants Hospital of Rhode Island, Providence

N6C 0A7

London Health Sciences Centre (London Regional Cancer Centre), London

M5G 2M9

University Health Network (PMCC), Toronto

H4A 3J1

McGill University Health Centre (MUHC), Montreal

Unknown

Henan Cancer Hospital, Zhengzhou

Hunan Cancer Hospital, Changsha

01307

University Hospital Dresden, Dresden

151 23

Iaso Hospital, Marousi

08035

Hospital Universitari Vall d' Hebrón, Barcelona

08036

Hospital Universitari Clínic de Barcelona, Barcelona

08227

Consorci Sanitari de Terrassa, Barcelona

071998

Hospital Son Llàtzer, Palma

Sponsors
All Listed Sponsors
collaborator

Belgian Gynaecological Oncology Group

OTHER

collaborator

North-Eastern German Society of Gynaecologic Oncology

UNKNOWN

collaborator

Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies

UNKNOWN

collaborator

Spanish Research Group in Ovarian Cancer

UNKNOWN

collaborator

The Central and Eastern European Gynecologic Oncology Group

OTHER

collaborator

Israeli Society of Gynecologic Oncology

OTHER

collaborator

GOG Foundation

NETWORK

lead

Karyopharm Therapeutics Inc

INDUSTRY