A Study of Selinexor Monotherapy in Subjects with JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

PHASE2RecruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

April 22, 2024

Primary Completion Date

April 30, 2026

Study Completion Date

October 31, 2028

Conditions
MyelofibrosisModerate Thrombocytopenia
Interventions
DRUG

Selinexor 60 mg

Participants will receive selinexor 60 mg oral tablets QW.

DRUG

Selinexor 40 mg

Participants will receive selinexor 40 mg oral tablets QW.

DRUG

Ruxolitinib

Participants will receive ruxolitinib 5 mg or 10 mg twice daily.

DRUG

Pacritinib

Participants will receive pacritinib 200 mg twice daily.

DRUG

Momelotinib

Participants will receive momelotinib 200 mg once daily.

Trial Locations (48)

128

RECRUITING

Università Campus Bio-Medico di Roma, Rome

1088

RECRUITING

Semmelweis Egyetem, Budapest

1431

RECRUITING

University Hospital Sv.Ivan Rilski - Sofia, Sofia

RECRUITING

University Multiprofile Hospital for Active Treatment Aleksandrovska, Sofia

1756

RECRUITING

Specialized Hospital for Active Treatment of Hematological Diseases - EAD Sofia, Sofia

3000

RECRUITING

UZ Leuven - Campus Gasthuisberg, Leuven

3722

RECRUITING

Severance Hospital, Seoul

4002

RECRUITING

University Multiprofile Hospital for Active Treatment Sveti George - Base 1, Plovdiv

6003

RECRUITING

University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich AD Department of Clinical Hematology, Stara Zagora

6591

RECRUITING

Seoul St. Mary's Hospital, The Catholic University of Korea, Seocho-gu

7747

RECRUITING

University Hospital Jena, Jena

9000

RECRUITING

UZ Gent, Ghent

10003

RECRUITING

Hospital San Pedro de Alcantara, Cáceres

10021

RECRUITING

Weill Cornell Medicine NewYork-Presbyterian, New York

10043

RECRUITING

Hematology Division, Mauriziano Hospital, University of Turin, Orbassano

16132

RECRUITING

IRCCS Ospedale Policlinico San Martino, Genova

17007

RECRUITING

Institut Català d'Oncologia Girona, Girona

20122

RECRUITING

Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

21044

RECRUITING

Maryland Oncology Hematology - Independent of SCRI/ US Oncology, Columbia

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo, Pavia

27705

RECRUITING

Duke University, Durham

30029

RECRUITING

Chu De Nîmes - Institut De Cancérologie Du Gard, Nîmes

30120

RECRUITING

Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar

30167

RECRUITING

Coltea - Spital Clinic, Bucharest

33011

RECRUITING

Hospital Universitario Central de Asturias, Oviedo

35010

RECRUITING

Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria

37007

RECRUITING

Complejo Asistencial Universitario de Salamanca - Hospital Clínico, Salamanca

37044

RECRUITING

CHU Tours, Hôpital Bretonneau Service d'Hématologie thérapie cellulaire, Tours

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna

40479

RECRUITING

Marien Hospital Düsseldorf, Düsseldorf

42270

RECRUITING

Centre Hospitalier Universitaire de Saint-Etienne, Saint-Priest-en-Jarez

44195

RECRUITING

Cleveland Clinic, Cleveland

46010

RECRUITING

Hospital Clínico Universitario de Valencia, Valencia

49241

RECRUITING

Pusan National University Hospital, Busan

69495

RECRUITING

Centre Hospitalier Lyon-Sud, Pierre-Bénite

75010

RECRUITING

Hôpital Saint-Louis, Paris

75014

RECRUITING

Hôpital Cochin, Paris

84112

RECRUITING

Huntsman Cancer Institute, Salt Lake City

91010

RECRUITING

City of Hope - Duarte Main Site, Duarte

200143

RECRUITING

Spitalul Filantropia - Craiova, Craiova

H4A 3J1

RECRUITING

Research Institute of the McGill University Health Centre, Montreal

49 933

RECRUITING

Centre Hospitalier Universitaire d'Angers, Angers

Unknown

RECRUITING

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST, Meldola

2134 TM

RECRUITING

Spaarne Gasthuis, Hoofddorp

20-954

RECRUITING

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin

30 60-185

RECRUITING

AIDPORT, Skórzewo

87-100

RECRUITING

Medicover Clinical Integrated Systems Sp. z o.o., Torun

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY