353
Participants
Start Date
March 11, 2021
Primary Completion Date
March 31, 2026
Study Completion Date
March 31, 2028
Selinexor
Participants will receive a dose of 40 or 60 mg selinexor oral tablets QW.
Selinexor
Participants will receive a dose of 60 mg selinexor oral tablets QW.
Placebo
Participants will receive a matching placebo of selinexor oral tablets QW
Ruxolitinib
Participants will receive a dose of 15 or 20 mg ruxolitinib oral tablets BID.
Semmelweis Egyetem, Budapest
University Multiprofile Hospital for Active Treatment Aleksandrovska, Sofia
University Multiprofile Hospital for Active Treatment St. Ivan Rilski, Sofia
Specialized Hospital for Active Treatment of Hematological Diseases - EAD Sofia, Sofia
ZNA Stuivenberg - Satelite, Antwerp
ZNA Stuivenberg, Antwerp
Liverpool Hospital, Liverpool
Bankstown-Lidcombe Hospital, Bankstown
Campbelltown Hospital, Campbelltown
Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven
University Multiprofile Hospital for Active Treatment Sveti George - Base 1, Plovdiv
Icon Cancer Centre - Wesley, South Brisbane
Royal Adelaide Hospital, Adelaide
University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich, Stara Zagora
One Clinical Research, Nedlands
Universitätsklinikum Halle, Halle
Samsung Medical Center, Seoul
Universitätsklinikum Jena, Jena
Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan, Bruges
Aarhus Universitetshospital, Aarhus N
Universitair Ziekenhuis Gent, Ghent
Tang Severinsen, Marianne, Aalborg
Győr-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház, Győr
Hospital San Pedro de Alcantara, Cáceres
Mount Sinai Health System, New York
National Taiwan University Hospital, Taipei
Memorial Sloan Kettering Cancer Center, New York
Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino
Azienda Ospedaliera Ordine Mauriziano di Torino, Torino
Seoul National University Bundang Hospital, Seongnam-si
IRCCS Ospedale Policlinico San Martino, Genova
Institut Català d'Oncologia Girona (ICO Girona), Girona
Georgetown Lombardi Comprehensive Center, Washington D.C.
Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan
Spitalul Clinic Colentina, Bucharest
Istituto Europeo di Oncologia, Milan
USOR - Virginia Cancer Specialists - Gainesville Office, Gainesville
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan
Maryland Oncology Hematology-Satellite, Rockville
Fondazione IRCCS San Gerardo dei Tintori, Monza
Maryland Oncology Hematology-Satellite, Silver Spring
Maryland Oncology Hematology-Satellite, Brandywine
Maryland Oncology Hematology, Columbia
The Sidney Kimmel Comprehensive Cancer Center, Baltimore
Maryland Oncology Hematology-Satellite, Annapolis
VCU Massey Cancer Center, Richmond
USOR - Virginia Oncology Associates - Virginia Beach, Virginia Beach
Städtisches Krankenhaus Kiel, Kiel
West Virginia University Cancer Institute, Wheeling Hospital, Wheeling
Hospital Universitario Lucus Augusti, Lugo
Fondazione IRCCS Policlinico San Matteo, Pavia
Duke Cancer Institue, Durham
Hospital General Universitario Gregorio Marañón, Madrid
Hospital Universitario Ramón y Cajal, Madrid
Hospital Universitario 12 de Octubre, Madrid
Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara, Novara
Hospital Universitario Virgen de la Victoria, Málaga
Hôpital Morvan, Brest
Chu De Nîmes - Institut De Cancérologie Du Gard, Nîmes
Hospital Clínico Universitario Virgen de la Arrixaca, Murcia
Institut Bergonié, Bordeaux
Hospital Universitario Central de Asturias, Oviedo
Chang Gung Memorial Hospital - Linkou Branch, Taoyuan District
Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria
UAB Division of Hematology/Oncology, Birmingham
Complejo Asistencial Universitario de Salamanca - Hospital Clínico, Salamanca
Hôpital Bretonneau, Tours
Centro Ricerche Cliniche di Verona, Verona
Vanderbilt Ingram Cancer Center, Nashville
Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi, Bologna
Norton Cancer Institute - Saint Matthews, Louisville
China Medical University Hospital, Taichung
Marien Hospital Düsseldorf, Düsseldorf
University General Hospital of Larissa, Hematology Department, Larissa
Kyungpook National University Hospital, Daegu
Centre Hospitalier Universitaire de Saint-Étienne, Saint-Priest-en-Jarez
Ohio State University Comprehensive Cancer Center (OSUCCC) - The James Cancer Hospital and Solove Research Institute, Columbus
OhioHealth, Columbus
USOR - Oncology Hematology Care - Kenwood, Cincinnati
Hospital Clínico Universitario de Valencia, Valencia
"Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST", Meldola
Pusan National University Hospital, Busan
The Cancer & Hematology Centers of Muskegon, Norton Shores
The Cancer & Hematology Centers -Satellite Site, Grand Rapids
Hospital de Día Quirónsalud Zaragoza, Zaragoza
Azienda Ospedaliero - Universitaria Careggi, Florence
University of Wisconsin - Madison, Madison
Chonnam National University Hwasun Hospital, Hwasun
Hôpital Huriez, Lille
Centre Hospitalier Universitaire Estaing, Clermont-Ferrand
Hôpital Emile Muller, Mulhouse
Centre Hospitalier Lyon-Sud, Pierre-Bénite
Kliniken Ostalb - Stauferklinikum Schwäbisch Gmünd, Mutlangen
Hôpital Saint-Louis, Paris
Hôpital Universitaire Pitié Salpêtrière, Paris
Hôpital Cochin, Paris
Texas Oncology, Dallas
University of Texas MD Anderson Cancer Center, Houston
USOR - Rocky Mountain Cancer Centers - Aurora, Aurora
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Chang Gung Memorial Hospital - Kaohsiung Branch, Kaohsiung City
Huntsman Cancer Institute, Salt Lake City
IRCCS Centro di Riferimento Oncologico di Basilicata, Rionero in Vulture
UCLA, Los Angles
UCLA - Satellite Site, Beverly Hills
City of Hope, Duarte
The Oncology Institute of Hope & Innovation, Pasadena
City of Hope - Irvine Lennar - Satellite, Irvine
UCLA - Satellite Site, Encino
Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco - Catania/ Presidio G. Rodolico, Catania
Fred Hutchinson Cancer Center - SCAA South Lake Union, Seattle
Spitalul Filantropia - Craiova, Craiova
Institutul Oncologic Prof. Dr. Ion Chiricuta, Cluj-Napoca
Spitalul Clinic Judetean De Urgenta Târgu Mureș, Târgu Mureş
Institutul Regional De Oncologie Iasi, Iași
Emek Medical Center, Afula
Western Galilee Hospital-Nahariya, Nahariya
Rambam Health Care Campus, Haifa
Carmel Medical Center, Haifa
The Chaim Sheba Medical Center, Ramat Gan
Tel Aviv Sourasky Medical Center, Tel Aviv
Shamir Medical Center (Assaf Harofeh), Be’er Ya‘aqov
Hadassah University Hospital - Mount Scopus - Satellite Site, Jerusalem
Hadassah University Hospital Ein Kerem, Jerusalem
Smilow Cancer Hospital - New Haven, New Haven
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack
University of Alberta Hospital, Edmonton
Lakeridge Health, Oshawa
Research Institute of the McGill University Health Centre, Montreal
Vseobecna Fakultni Nemocnice v Praze, Prague
Fakultní Nemocnice Hradec Králové, Hradec Králové
Fakultní Nemocnice Olomouc, Olomouc
Hôpital l'Archet - CHU Nice, Nice
Centre Hospitalier Universitaire d'Angers, Angers
Laiko General Hospital of Athens, Athens
"General Hospital of Athens Alexandra", Athens
University General Hospital Attikon, Athens
General Hospital of Thessaloniki George Papanikolaou, Thessaloniki
University General Hospital of Ioannina, Ioánnina
Umberto I - Policlinico di Roma, Roma
Università Campus Bio-Medico di Roma, Rome
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma
Spaarne Gasthuis - Hoofddorp, Hoofddorp
Universitair Medisch Centrum Groningen, Groningen
AIDPORT, Skórzewo
Medicover Integrated Clinical Services (MICS) - Centrum Medyczne Toruń, Torun
Dolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku, Wroclaw
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie, Lublin
Szpital Specjalistyczny w Brzozowie - Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza, Brzozów
Uniwersyteckie Centrum Kliniczne w Gdańsku, Gdansk
Pratia Onkologia Katowice, Katowice
Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu, Wałbrzych
Coltea - Spital Clinic, Bucharest
Seoul National University Hospital, Seoul
Severance Hospital, Seoul
The Catholic University of Korea - Seoul St. Mary's Hospital, Seoul
Institut Català d'Oncologia Badalona, Badalona
Hospital Universitari Vall d'Hebrón, Barcelona
Hospital Clinic de Barcelona, Barcelona
Guy's and St Thomas' NHS Foundation Trust, London
Oxford University Hospitals NHS Foundation Trust, Oxford
United Lincolnshire Hospitals NHS Trust-Satellite Site, Boston
United Lincolnshire Hospitals NHS Trust, Boston
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
Imperial College Healthcare NHS Trust, London
The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne
Lead Sponsor
Karyopharm Therapeutics Inc
INDUSTRY