A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma

PHASE3RecruitingINTERVENTIONAL
Enrollment

222

Participants

Timeline

Start Date

April 19, 2022

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2029

Conditions
Multiple Myeloma
Interventions
DRUG

Selinexor

Selinexor will be given as an oral dose 40 mg (2 20 mg tablets) QW on Days 1, 8, 15, and 22 of each 28-day cycle.

DRUG

Elotuzumab

Elotuzumab will be given IV 10 mg/kg on Days 1, 8, 15, and 22 of cycle 1 and 2 then 20 mg/kg on Day 1 of cycles ≥3 of each 28-day cycle.

DRUG

Pomalidomide

Pomalidomide will be given as an oral 4 mg dose QD on Days 1 to 21 of each 28-day cycle.

DRUG

Dexamethasone Oral

Dexamethasone will be given as an oral 40 mg dose QW on Days 1, 8, 15, and 22 of each 28-day cycle. Preferred dosing of dexamethasone is 40 mg QW for patients who are ≤75 years of age (20 mg QW for \>75-year-old patients at the Investigator's discretion) before QW dosing of selinexor, however, it may be divided over 2 days at the Investigator's discretion.

Trial Locations (94)

10126

RECRUITING

A.O.U. Città della Salute e della Scienza di Torino - SC Ematologia U, Torino

19611

RECRUITING

Reading Hospital - McGlinn Cancer Institute, West Reading

20817

RECRUITING

American Oncology Partners of Maryland, Bethesda

27103

RECRUITING

Novant Health Cancer Institute-Forsyth Medical Center, Winston-Salem

27834

NOT_YET_RECRUITING

East Carolina University, Greenville

28100

NOT_YET_RECRUITING

A.O.U. Maggiore della Carità di Novara, Novara

28204

RECRUITING

Novant Health Cancer Institute, Charlotte

29303

RECRUITING

Gibbs Cancer Center, Spartanburg

29425

NOT_YET_RECRUITING

Medical University of South Carolina. Hollings Cancer Center, Charleston

32308

RECRUITING

Florida Cancer Specialists Panhandle, Tallahassee

33024

RECRUITING

Millennium Oncology Research Clinic, Hollywood

33401

RECRUITING

Florida Cancer Specialists East, West Palm Beach

33486

RECRUITING

Baptist Health South Florida, Delray Beach

33705

RECRUITING

Florida Cancer Specialists North, St. Petersburg

33901

NOT_YET_RECRUITING

Florida Cancer Specialists South, Fort Myers

48236

NOT_YET_RECRUITING

Ascension St. John Hospital, Grosse Pointe Woods

51101

NOT_YET_RECRUITING

June E. Nylen Cancer Center, Sioux City

68506

RECRUITING

Nebraska Hematology - Oncology, P.C., Lincoln

70808

RECRUITING

Our Lady of the Lake Hospital, Baton Rouge

70809

RECRUITING

Hematology Oncology Clinic, Baton Rouge

77090

RECRUITING

Millennium Research & Clinical Development, Houston

79915

RECRUITING

Renovatio Clinical Research, El Paso

80528

NOT_YET_RECRUITING

UCHealth Cancer Center - Harmony Campus, Fort Collins

85724

NOT_YET_RECRUITING

The University of Arizona Cancer Center, Tucson

89511

RECRUITING

Cancer Care Specialists, Reno

90017

RECRUITING

Los Angeles Hematology Oncology Medical Group, Los Angeles

90069

RECRUITING

Berenson Oncology, West Hollywood

90602

RECRUITING

The Oncology Institute of Hope and Innovation, Whittier

92024

RECRUITING

California Cancer Associates for Research and Excellence, Encinitas

92618

NOT_YET_RECRUITING

Kaiser Permanente Southern California, Irvine

93701

NOT_YET_RECRUITING

University of California, San Francisco, Fresno

96813

RECRUITING

Hawaii Cancer Care, Honolulu

08103-1461

NOT_YET_RECRUITING

MD Anderson Cancer Center at Cooper, Camden

Unknown

RECRUITING

CHRU Hôpital Claude Huriez, Lille

RECRUITING

CHRU Hôtel Dieu, Nantes

NOT_YET_RECRUITING

CHU Hôpital Saint Antoine, Paris

RECRUITING

La Pitié, Paris

RECRUITING

Paris Necker, Paris

NOT_YET_RECRUITING

CHU Poitiers - Pôle régional de Cancérologie, Poitiers

RECRUITING

Pôle IUCT Oncopole CHU, Toulouse

RECRUITING

Johanniter Krankenhaus Bonn, Bonn

RECRUITING

Klinikum Chemnitz, Chemnitz

RECRUITING

University Hospital of Cologne, Cologne

RECRUITING

Marien Hospital Dusseldorf, Düsseldorf

RECRUITING

University Medicine Greifswald, Medical Clinic and Polyclinic for Internal Medicine, Greifswald

RECRUITING

Universitätsklinikum Hamburg - Eppendorf, Hamburg

RECRUITING

KRH Klinikum Siloah, Hanover

NOT_YET_RECRUITING

University Hospital of Heidelberg, Heidelberg

RECRUITING

Red Cross Hospital Munich, München

NOT_YET_RECRUITING

University Hospital of Münster, Münster

NOT_YET_RECRUITING

University Hospital of Würzburg, Würzburg

RECRUITING

Alexandra General Hospital -Department of Clinical Therapeutics N.K. Univ. of Athens, Athens

RECRUITING

"General Hospital of AthensEvangelismos", Athens

NOT_YET_RECRUITING

St Savvas Cancer Hospital, Athens

RECRUITING

University General Hospital of Patras, Pátrai

RECRUITING

Theagenion Cancer Hospital, Thessaloniki

NOT_YET_RECRUITING

Azienda Ospedaliero-Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi Di Ancona, Ancona

RECRUITING

A.O. Papa Giovanni XXIII, Bergamo

RECRUITING

Bologna, Bologna

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna

RECRUITING

AO Spedali Civili di Brescia - Ematologia, Brescia

NOT_YET_RECRUITING

Ospedale Oncologico 'A. Businco', Cagliari

RECRUITING

Aou Policlinico Rodolico San Marco, Catania

RECRUITING

A.O.U. Careggi, Florence

RECRUITING

A.O.U. Policlinico S. Martino - Ematologia, Genova

RECRUITING

Ospedale Civile di Legnano. ASST Ovest Milanese, Legnano

RECRUITING

Hospital IRST, Meldola

NOT_YET_RECRUITING

A.O.U. Policlinico 'G. Martino', Messina

RECRUITING

Azienda Ospedaliera Papardo, Messina

RECRUITING

ASST Santi Paolo e Carlo. SC Ematologia, Milan

RECRUITING

European Institute of Oncology, Haematology Division and Department, Milan

RECRUITING

A.O.U. Maggiore della Carità, Novara

RECRUITING

Ospetale Santo Spirito, Pescara

RECRUITING

UO Ematologia, Ospedale Santa Maria Delle Croci, AUSL Romagna, Ravenna

RECRUITING

Ospedale S. Eugenio, Roma

NOT_YET_RECRUITING

A.O. S. Maria, Terni

RECRUITING

SC Oncoematologia AO S. Maria di Terni, Terni

RECRUITING

Azienda Ospedaliera Universitaria di Udine, Udine

RECRUITING

Amphia ziekenhuis, Breda

RECRUITING

Erasmus MC, Rotterdam

RECRUITING

Hospital Clinic I Provincial de Barcelona, Barcelona

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

RECRUITING

Institut Catala D Oncolocia Hospitalet - Hospital Duran i Reynals, Barcelona

RECRUITING

Hospital de Cabueñes, Gijón

RECRUITING

Institut Català D'Oncologia - Hospital Dr. Josep Trueta, Girona

RECRUITING

Complejo Asistencial Universitario de Leon, León

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

RECRUITING

H. General Universitario Morales Meseguer, Murcia

RECRUITING

Clínica Universidad de Navarra (CUN), Pamplona

RECRUITING

Hospital Universitario de Salamanca, Salamanca

RECRUITING

H. Universitario Marqués de Valdecilla, Santander

RECRUITING

Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela

RECRUITING

H.U. La Fe, Valencia

Sponsors
All Listed Sponsors
collaborator

Karyopharm Therapeutics Inc

INDUSTRY

lead

Stichting European Myeloma Network

NETWORK