Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

PHASE2RecruitingINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

November 30, 2014

Primary Completion Date

April 30, 2027

Study Completion Date

November 30, 2027

Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG

Selinexor

Dose: 60 mg (BIW); Dosage form: film-coated (20 mg each) immediate release tablets; Route of administration: Oral

DRUG

Selinexor

Dose: 40 mg (BIW); Dosage form: film-coated (20 mg each) immediate release tablets; Route of administration: Oral

DRUG

Selinexor

Dose: 60 mg (BIW) and 60 mg (QW); Dosage form: film-coated (20 mg each) immediate release tablets; Route of administration: Oral

Trial Locations (176)

1000

COMPLETED

Institut Jules Bordet, Brussels

1083

COMPLETED

Semmelweis Egyetem Általános Orvosi Kar, Budapest

1122

COMPLETED

"Országos Onkológiai Intézet A Belgyógyászati Onkológiai Osztály", Budapest

1431

COMPLETED

University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD, Sofia

1756

COMPLETED

Specialized Hospital for Active Treatment of Haematological Diseases EAD, Sofia

2010

COMPLETED

St. Vincent's Hospital Sydney, Darlinghurst

2170

COMPLETED

Liverpool Hospital, Ingham Institute of Medical Research, Liverpool

2298

COMPLETED

Calvary Mater Newcastle Hospital, Waratah

3001

COMPLETED

Epworth Hospital, East Melbourne

3004

COMPLETED

The Alfred Hospital, Melbourne

3065

COMPLETED

St. Vincent's Melbourne, Fitzroy

3168

COMPLETED

Monash Medical Centre, Clayton

4101

COMPLETED

Icon Cancer Care, South Brisbane

5000

COMPLETED

Royal Adelaide Hospital, Adelaide

5037

COMPLETED

Ashford Cancer Centre, Kurralta Park

5800

COMPLETED

University Hospital for Active Treatment Dr. Georgi Stranski, Pleven

6150

COMPLETED

Fiona Stanley Hospital, Murdoch

7100

COMPLETED

CH Jolimont, La Louvière

7400

COMPLETED

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár

8000

COMPLETED

AZ Sint-Jan, Bruges

8001

COMPLETED

Christchurch Hospital, Christchurch

8036

COMPLETED

Medical University of Graz, Graz

8200

COMPLETED

Veszprém Megyei Csolnoky Ferenc Kórház, Veszprém

8700

COMPLETED

LKH Leoben Department for Haemato-Oncology, Leoben

8916

COMPLETED

Hospitla Universitari Germans Trias i Pujol - ICO, Badalona

9000

COMPLETED

UZ Gent, Ghent

10065

COMPLETED

New York Presbyterian Hospital/ Cornell Medical College, New York

11000

COMPLETED

Institut za onkologiju i radiologiju Srbije, Belgrade

COMPLETED

Klinicko Bolnick Centar Zemun Odeljenje hematologije, Belgrade

COMPLETED

Klinički centar Srbije Klinika za hematologiju, Belgrade

COMPLETED

Kliničko bolnički centar Zvezdara, Belgrade

11527

RECRUITING

Hematology Clinic,General Hospital of Athens,G. Gennimatos, Athens

COMPLETED

National & Kapodistrian University of Athens, Laiko General Hospital, Athens

11794

COMPLETED

Stony Brook University Hospital, Stony Brook

12462

COMPLETED

National & Kapodistrian University of Athens, Attiko University Hospital, Chaïdári

18000

COMPLETED

Klinički centar Niš Klinika za hematologiju, Niš

21204

COMPLETED

Institut za onkologiju Vojvodine, Kamenitz

26504

COMPLETED

University of Patras Medical School, Pátrai

28100

COMPLETED

SCDU Ematologia, Division of Hematology, Dept. of Translational Medicine, Universita del Piemonte Orientale, Novara

28239

COMPLETED

Ev. Diakonie-Krankenhaus gGmbH, Bremen

29605

COMPLETED

Greenville Hospital System, Greenville

37007

COMPLETED

Hospital Universitario de Salamanca, Salamanca

40241

COMPLETED

Norton Cancer Institute, Louisville

44195

COMPLETED

Cleveland Clinic Foundation, Cleveland

44718

COMPLETED

Gabrail Cancer Center, Canton

45110

RECRUITING

Department of clinical hematology ,university hospital Ioannina, Ioannina

49100

COMPLETED

Rabin Medical Center, Petah Tikva

50134

RECRUITING

SODc Ematologica ,AOU Careggi, Florence

60637

COMPLETED

University of Chicago, Chicago

69710

COMPLETED

Assuta Medical Center, Tel Aviv

70016

COMPLETED

Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata

75010

COMPLETED

Hostpial Saint Louis - CIRCO (Centre d'Investigations et de Recherche Clinique en Oncologie), Paris

77030

COMPLETED

MD Anderson, Houston

80131

RECRUITING

Hematology-Oncology & Stem Cell Transplantation Unit, National Cancer Institute, Fondazione 'G. Pascale', IRCCS, Naples

85704

COMPLETED

UACC Arizona, Tucson

90404

COMPLETED

University of California Los Angeles (UCLA), Santa Monica

90419

COMPLETED

Klinikum Nürnberg Nord, Nuremberg

98104

COMPLETED

Swedish Cancer Institute, Seattle

110029

COMPLETED

IRCH, All India Institute of Medical Sciences, Delhi

COMPLETED

Dr. B.R.A. Institute Rotary Cancer Hospital All India Institute of Medical Sciences, New Delhi

110085

COMPLETED

Rajiv Gandhi Cancer Hospital, New Delhi

160012

COMPLETED

Dayanand Medical College and Hospital, Ludhiana

226003

COMPLETED

King George's Medical University (KGMU), Lucknow

400010

COMPLETED

Prince Aly Khan Hospital, Mumbai

400026

COMPLETED

Jaslok Hospital and Research Centre, Mumbai

411004

COMPLETED

Deenanath Mangeshkar Hospital, Pune

600020

COMPLETED

Cancer Institute (WIA), Chennai

600026

COMPLETED

SRM Institutes for Medical Science, Vadapalani

602105

COMPLETED

Saveetha Medical College Hospital, Chennai

625107

COMPLETED

Meenakshi Mission Hospital & Research Centre, Madurai

641037

COMPLETED

G. Kuppu Swamy Naidu Hospital, Coimbatore

695011

COMPLETED

Regional Cancer Centre, Thiruvananthapuram

700014

COMPLETED

Nil Ratan Sircar Medical College and Hospital, Kolkata

700094

COMPLETED

Netaji Subhas Chandra Bose Cancer Research Hospital, Kolkata

700156

COMPLETED

TATA Memorial Centre, Kolkata

751003

COMPLETED

Institute of Medical Sciences & SUM Hospital, Bhubaneswar

800014

COMPLETED

Regional Cancer Centre, IGIMS, Patna

Unknown

COMPLETED

University of California San Francisco, San Francisco

COMPLETED

Boca Raton Cancer Research Medical Center, Plantation

COMPLETED

Robert H. Lurie Comprehensive Cancer Center/Northwestern University, Chicago

COMPLETED

Dana Farber Cancer Institute, Boston

COMPLETED

Tufts Medical Center, Boston

COMPLETED

Lahey Clinic, Burlington

COMPLETED

University of Massachusetts Medical School, Worcester

COMPLETED

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

COMPLETED

Clinical Research Alliance, Lake Success

COMPLETED

University Hospitals Seidman Cancer Center, Cleveland

COMPLETED

University of Oklahoma, Oklahoma City

COMPLETED

Virginia Mason Hospital & Medical Center, Seattle

COMPLETED

Medizinische Universität Innsbruck für Innere Medizin, Innsbruck

COMPLETED

Akh Linz Innere Med III - Zentrum für Hämatologie und med. Onkologie, Linz

COMPLETED

Krankenhaus Barmherzigen Schwestern Linz, Linz

COMPLETED

Krankenhaus der Elisabethinen Linz GmbH, Linz

COMPLETED

Medical University of Vienna (MUW) Department of Medicine I, Vienna

COMPLETED

Univ. General Hospital Hietzing, Vienna

COMPLETED

Ziekenhuis Netwerk Antwerpen, Antwerp

COMPLETED

Cliniques Universitaires Saint-Luc, Brussels

COMPLETED

AZ Delta, Roeselare

COMPLETED

H-Hartziekenhuis Roeselare-Menen, Roeselare

COMPLETED

Princess Margaret Cancer Centre, Toronto

COMPLETED

Sir Mortimer B Davis Jewish General Hospital/McGill University, Montreal

COMPLETED

CHU Lyon Sud, Pierre-Bénite

COMPLETED

Centre Hospitalier Universitaire Henri Mondor, Créteil

COMPLETED

Unite Hemopathies Lymphoides Chu Henri Mondor, Créteil

COMPLETED

Chu Dijon-Bourgogne - Hematologie Clinique, Dijon

COMPLETED

Hospitalier de la Rochelle-Ré-Aunis, La Rochelle

COMPLETED

CHRU de Lille - Hopital Claude-Huriez, Lille

COMPLETED

Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes, Marseille

COMPLETED

CHU Montpellier, Montpellier

COMPLETED

Hôpital Necker Service d'Hématologie Adult, Paris

SUSPENDED

Pitié-Salpêtrière Hospital, Paris

SUSPENDED

Centre Henri Becquerel, Rouen

COMPLETED

Uniklinik Aachen Klinik für Hämatologie, Onkologie, Hämostaseologie und Stammzelltransplantation, Aachen

COMPLETED

HELIOS Klinikum Bad Saarow, Bad Saarow

COMPLETED

Charite Universitatsmedizin Berlin (Benjamin Franklin Campus), Berlin

COMPLETED

Charite Universitatsmedizin Berlin (Virchow Campus), Berlin

COMPLETED

Klinikum Kempten Klinik für Innere Medizin III - Hämatologie, Onkologie und Palliativmedizin, Cologne

COMPLETED

Martin-Luther-University Halle-Wittenberg Department of Oncology, Halle

COMPLETED

Medizinische Hochschule, Hanover

COMPLETED

Universität Heidelberg Medizinische Klinik V Hämatologie, Onkologie und Rheumatologie, Heidelberg

COMPLETED

Klinikum Leverkusen, Leverkusen

COMPLETED

Klinikum Ludwigshafen, Ludwigshafen

COMPLETED

Rotkreuzklinikum München, München

RECRUITING

Haematology Department and HCT Unit G.Papanicolaou Hospital, Exochi

RECRUITING

Hematology Department Laiko General Hospital, Athens

RECRUITING

Second Depth of Internal Medicine, Attiko University Hospital, Athens

COMPLETED

Semmelweis University Department of Medicine and Oncology, Budapest

COMPLETED

Pécsi Tudományegyetem, ÁOK, I. számú Belgyógyászati Klinika, Pécs

COMPLETED

CSolnoky ferenc Hospital, Veszprém

COMPLETED

Hematology-Soroka, Beersheba

COMPLETED

Rambam Healthcare Campus, Haifa

COMPLETED

Wolfson MC, Holon

COMPLETED

Hadassah Medical Center, Jerusalem

COMPLETED

TLV Sorasky Medical Center, Tel Aviv

COMPLETED

Sheba Medical Center, Tel Litwinsky

COMPLETED

Instituto di Ematologia Seragnoli Pad 8 Universita di Bologna, Bologna

RECRUITING

AOU Maggiore della Carità SCDU Ematologia, Florence

RECRUITING

Fondazione Policlinico Universitario A. Gemelli, Rome

RECRUITING

Azienda Ospedaliero-Universitaria Senese, Siena

COMPLETED

Città della Salute e della Scienza di Torino, Torino

COMPLETED

LUMC (leidse universitair medisch centrum), Leiden

COMPLETED

Hematology Department St John's Cancer Centre, Lublin

RECRUITING

Maria Sklodowska Curie National Research Institute, Warsaw

COMPLETED

Hospital Clinic i Provincial de Barcelona, Barcelona

COMPLETED

Hospital Universitario La Paz, Madrid

COMPLETED

Hospital de Son Llàtzer, Palma de Mallorca

COMPLETED

Clínica Universidad De Navarra, Pamplona

COMPLETED

Hospital Universitario Virgen del Rocio, Seville

COMPLETED

Leeds Teaching Hospitals NHS Trust, Leeds

COMPLETED

Royal Liverpool University Hospital, Liverpool

COMPLETED

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

COMPLETED

Guy's and St Thomas' NHS Foundation Trust, London

A-5020

COMPLETED

Uni. Klinik für Innere Medizin III Universitätsklinikum der PMU LKH Salzburg, Salzburg

01307

COMPLETED

Gemeinschaftspraxis Haematologie and Onkologie-Dresden, Dresden

1081 HV

COMPLETED

VUMc (Vrije Universiteit Amsterdam), Amsterdam

0622

COMPLETED

North Shore Hospital, Auckland

50-367

RECRUITING

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza, Wroclaw

81-519

COMPLETED

Szpitale Wojewódzkie w Gdyni, Gdyńskie Centrum onkologii, Gdynia

30-510

COMPLETED

MCM (Małopolskie Centrum Medyczne), Krakow

59-220

RECRUITING

Wojewodzki Szpital Specjalistyczny w Legnicy, Legnica

62-1010

COMPLETED

Memorial Provincial Specialist Hospital in Lodz, Lodz

20-081

WITHDRAWN

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin

10-228

COMPLETED

Samodzielny Publiczny Zakład Opieki Zdrowotnej Ministerstwa, Olsztyn

02-776

COMPLETED

Instytut Hematologii i Transfuzjologii, Warsaw

02-781

COMPLETED

Centrum Onkologii- Insytut Im. Marii Skłodowskiej-Curie Klinika Nowotworow Ukladu Chlonnego, Warsaw

08035

COMPLETED

Hospital University Vall d'Hebron, Barcelona

GL1 3NN

COMPLETED

Gloucestershire Royal Hospital, Gloucester

SO16 6YD

COMPLETED

Southampton University Hospital, Southampton

SM2 5PT

COMPLETED

Royal Marsden Hospital, Sutton

HA1 3UJ

COMPLETED

Northwick Park Hospital, Harrow

CB2 0QQ

COMPLETED

Addenbrooke's Hospital Cambridge, Cambridge

SE5 9RS

COMPLETED

King's College Hospital, London

COMPLETED

Princess Royal University Hospital (PRUH), London

M20 4BX

COMPLETED

The Christie NHS Foundation Trust, Manchester

OX3 7LE

COMPLETED

Oxford University Hospitals NHS Trust Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford

PL6 8DH

COMPLETED

Derriford Hospital, Plymouth

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY