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Clinical Trials for Ascentage Pharma
Explore 36 clinical trials worldwide
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Showing 1-36 of 36 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Ascentage Pharma
Clinical Trials (36)
NCT07178912
Phase II Study of the Combination of Subcutaneous Blinatumomab and Olverembatinib in Patients With Philadelphia Chromosome (ph)-Positive and/or BCR::ABL1 Positive Acute Lymphoblastic Leukemia (ALL)
PHASE2
Not yet recruiting
60 participants
Started: Feb 27, 2026 · Completed: Sep 30, 2031
5 conditions
3 sponsors
1 location
NCT06817720
Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase
PHASE2
Recruiting
50 participants
Started: Oct 13, 2025 · Completed: Mar 7, 2027
1 condition
2 sponsors
1 location
NCT06641414
Lisaftoclax (APG-2575) Combined With Azacytidine (AZA) in the Treatment of Patients With Higher-risk Myelodysplastic Syndrome (GLORA-4).
PHASE3
Recruiting
490 participants
Started: Jan 22, 2025 · Completed: Dec 31, 2029
1 condition
1 sponsor
2 locations
NCT06687070
APG-2449 Monotherapy or in Combination With PLD in Patients With Platinum-resistant Recurrent OC or Advanced ST
PHASE1
Recruiting
50 participants
Started: Dec 17, 2024 · Completed: May 31, 2027
2 conditions
1 sponsor
1 location
NCT06640361
A Study of Olverembatinib in SDH-deficient GIST.
PHASE3
Recruiting
40 participants
Started: Nov 11, 2024 · Completed: Jun 30, 2029
1 condition
2 sponsors
1 location
NCT06182969
A Study of APG-2575 in Patients with Mild-to-moderate Systemic Lupus Erythematosus.
PHASE1/PHASE2
Recruiting
40 participants
Started: Aug 9, 2024 · Completed: Dec 31, 2026
1 condition
2 sponsors
1 location
NCT06401603
A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia
PHASE1
Recruiting
30 participants
Started: Aug 6, 2024 · Completed: Jan 1, 2029
2 conditions
2 sponsors
1 location
NCT06389292
A Pivotal Study of APG-2575 (Lisaftoclax) Combined With Azacitidine in the Treatment of Acute Myeloid Leukemia
PHASE3
Recruiting
486 participants
Started: Jun 11, 2024 · Completed: Mar 26, 2029
1 condition
1 sponsor
6 locations
NCT06319456
A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL.
PHASE3
Recruiting
344 participants
Started: Apr 7, 2024 · Completed: Aug 31, 2028
1 condition
1 sponsor
6 locations
NCT06423911
Study of Olverembatinib (HQP1351) in Patients With CP-CML
PHASE3
Recruiting
285 participants
Started: Feb 5, 2024 · Completed: Feb 28, 2026
3 conditions
1 sponsor
1 location
NCT06104566
Global Trial in APG2575 for Patients With CLL/SLL
PHASE3
Recruiting
400 participants
Started: Dec 20, 2023 · Completed: Oct 31, 2027
1 condition
1 sponsor
2 locations
NCT06051409
A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ALL.
PHASE3
Recruiting
350 participants
Started: Aug 31, 2023 · Completed: Oct 31, 2028
1 condition
2 sponsors
14 locations
NCT05773586
A Study to Investigate the Safety, Pharmacokinetics and Efficacy of APG-5918 in Healthy Subjects or Anemic Patients
PHASE1
Recruiting
105 participants
Started: Mar 13, 2023 · Completed: Mar 15, 2026
1 condition
1 sponsor
2 locations
NCT05701306
APG-115 Alone or in Combination With APG-2575 in Children With Recurrent or Refractory Neuroblastoma or Solid Tumors
PHASE1
Recruiting
100 participants
Started: Feb 28, 2023 · Completed: Dec 31, 2027
2 conditions
2 sponsors
3 locations
NCT05186012
APG-1252 Monotherapy or in Combination With Other Therapeutic Agent in Subjects With Relapsed or Refractory Non-Hodgkin Lymphoma
PHASE1/PHASE2
Recruiting
51 participants
Started: Jun 14, 2022 · Completed: Mar 31, 2026
1 condition
1 sponsor
4 locations
NCT05147467
Study of APG-2575 in Patients With Relapsed/Refractory CLL/SLL
PHASE2
Recruiting
75 participants
Started: Dec 28, 2021 · Completed: Dec 31, 2024
2 conditions
1 sponsor
11 locations
NCT04942067
APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma
PHASE1/PHASE2
Recruiting
108 participants
Started: Dec 23, 2021 · Completed: Dec 1, 2024
2 conditions
1 sponsor
3 locations
NCT04964518
A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)
PHASE1/PHASE2
Recruiting
24 participants
Started: Jul 30, 2021 · Completed: Oct 30, 2024
1 condition
1 sponsor
9 locations
NCT04496349
A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL
PHASE2
Recruiting
78 participants
Started: Jul 12, 2021 · Completed: May 31, 2027
2 conditions
1 sponsor
3 locations
NCT04785196
APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors
PHASE1/PHASE2
Recruiting
95 participants
Started: May 26, 2021 · Completed: Jan 31, 2027
2 conditions
2 sponsors
3 locations
NCT04643405
APG-1387 Plus Chemotherapy in Advanced Pancreatic Adenocarcinoma
PHASE1/PHASE2
Recruiting
44 participants
Started: Mar 17, 2021 · Completed: Dec 31, 2024
1 condition
1 sponsor
1 location
NCT04358393
A Study of APG-115 Alone or Combined With Azacitidine in Patients With AML, CMML, or MDS
PHASE1/PHASE2
Recruiting
69 participants
Started: Dec 4, 2020 · Completed: Dec 30, 2025
7 conditions
1 sponsor
8 locations
NCT04501120
Study of Lisaftoclax (APG-2575) Single Agent and Combination With Therapy in Patients Relapsed/Refractory AML
PHASE1/PHASE2
Recruiting
458 participants
Started: Sep 28, 2020 · Completed: Sep 30, 2029
2 conditions
2 sponsors
12 locations
NCT04494503
Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL
PHASE1/PHASE2
Recruiting
123 participants
Started: Aug 31, 2020 · Completed: Dec 31, 2025
2 conditions
1 sponsor
18 locations
NCT04275518
A Phase Ib Study of APG-115 Single Agent or in Combination With Azacitidine or Cytarabine in Patients With AML and MDS.
PHASE1
Recruiting
102 participants
Started: Jul 6, 2020 · Completed: Dec 31, 2025
2 conditions
2 sponsors
14 locations
NCT04568265
A Clinical Study of APG-1387 in Combination With Entecavir in Patients With Chronic Hepatitis B
PHASE2
Recruiting
122 participants
Started: Jun 3, 2020 · Completed: Oct 31, 2025
3 conditions
1 sponsor
4 locations
NCT04284488
Dose-escalation Study of APG-1387 and Toripalimab in Solid Tumors
PHASE1/PHASE2
Recruiting
104 participants
Started: Apr 10, 2020 · Completed: Apr 30, 2024
1 condition
1 sponsor
3 locations
NCT04215809
Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL
PHASE1
Recruiting
144 participants
Started: Mar 2, 2020 · Completed: Jun 30, 2027
1 condition
1 sponsor
9 locations
NCT04260022
Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL
PHASE1
Recruiting
62 participants
Started: Jan 9, 2020 · Completed: Jan 31, 2024
5 conditions
1 sponsor
8 locations
NCT03781986
APG-115 in Salivary Gland Cancer Trial
PHASE1/PHASE2
Active, not recruiting
41 participants
Started: Oct 28, 2019 · Completed: Jun 30, 2026
2 conditions
2 sponsors
3 locations
NCT04001777
A Study of APG-1252 Plus Osimertinib(AZD9291) in EGFR TKI Resistant NSCLC Patients
PHASE1
Active, not recruiting
80 participants
Started: Jul 4, 2019 · Completed: Jun 30, 2026
1 condition
2 sponsors
4 locations
NCT03913949
A Study to Evaluate the Safety,PK and PD of APG-2575 in Patients With Hematologic Malignancies
PHASE1
Active, not recruiting
74 participants
Started: Jun 3, 2019 · Completed: Dec 31, 2025
2 conditions
2 sponsors
5 locations
NCT03917043
APG-2449 in Patients With Advanced Solid Tumors
PHASE1
Recruiting
165 participants
Started: May 27, 2019 · Completed: Jan 31, 2028
5 conditions
2 sponsors
9 locations
NCT03611868
A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors
PHASE1/PHASE2
Active, not recruiting
230 participants
Started: Aug 29, 2018 · Completed: Dec 30, 2025
8 conditions
2 sponsors
21 locations
NCT03537482
APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies
EARLY_PHASE1
Recruiting
90 participants
Started: Aug 7, 2018 · Completed: Feb 15, 2025
1 condition
1 sponsor
5 locations
NCT03594422
A Study of HQP1351 in Patients With GIST or Other Solid Tumors
PHASE1
Recruiting
100 participants
Started: Jul 11, 2018 · Completed: Dec 31, 2026
2 conditions
2 sponsors
6 locations