Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

123

Participants

Timeline

Start Date

August 31, 2020

Primary Completion Date

October 20, 2024

Study Completion Date

December 31, 2025

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

APG-2575

APG-2575 orally once daily, every 28 days as a cycle.

DRUG

Rituximab

Rituximab 375mg/m2 ivgtt on C1D8 and 500mg/m2 ivgtt on C2-6D1.

DRUG

Ibrutinib

Ibrutinib 420mg orally once daily during C1D8-28 and following cycles.

Trial Locations (18)

Unknown

RECRUITING

Peking University Third Hospital, Beijing

RECRUITING

Chongqing Cancer Hospital, Chongqing

RECRUITING

Nanfang Hospital of Southern Medical University, Guangzhou

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital, Nanning

RECRUITING

The Affiliated Hospital of Guizhou Medical University, Guiyang

RECRUITING

The Fourth Hospital of Hebei Medical University, Shijiazhuang

RECRUITING

Henan Provincial Oncology Hospital, Zhenzhou

RECRUITING

Union Hospital medical college Huazhong University of Science and Technology, Wuhan

RECRUITING

Xiangya Hospital Central South University, Changsha

RECRUITING

The First Affiliated Hospital of Nanjing Medical University, Nanjing

RECRUITING

Zhongda Hospital Southeast University, Nanjing

RECRUITING

The First affiliated hospital of Soochow University, Suzhou

RECRUITING

The First affiliated hospital of Nanchang University, Nanchang

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

NOT_YET_RECRUITING

Fudan University Zhongshan Hospital, Shanghai

RECRUITING

Blood Diseases Hospital Chinese Academy of Medical Sciences, Tianjin

RECRUITING

The First Bethune Hospital of Jilin University, Hangzhou

RECRUITING

The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

Sponsors
All Listed Sponsors
lead

Ascentage Pharma Group Inc.

INDUSTRY

NCT04494503 - Study of APG2575 Single Agent and Combination Therapy in Patients With Relapsed/Refractory CLL/SLL | Biotech Hunter | Biotech Hunter