A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL.

PHASE3RecruitingINTERVENTIONAL
Enrollment

344

Participants

Timeline

Start Date

April 7, 2024

Primary Completion Date

August 31, 2027

Study Completion Date

August 31, 2028

Conditions
CLL/SLL
Interventions
DRUG

Lisaftoclax (APG-2575)

QD, oral administration, every 28 days for a dosing cycle.

DRUG

Acalabrutinib

BID, oral administration, every 28 days for a dosing cycle.

DRUG

Fludarabine

Every 28 days for a treatment cycle, administration of 6 cycles.

DRUG

Cyclophosphamide,CTX

Every 28 days for a treatment cycle, administration of 6 cycles.

DRUG

Rituximab

Every 28 days for a treatment cycle, administration of 6 cycles.

DRUG

Chlorambucil

Every 28 days for a treatment cycle, administration of 6 cycles.

Trial Locations (6)

233004

NOT_YET_RECRUITING

The First Affiliated Hospital of Bengbu Medical College, Bengbu

300020

RECRUITING

Hematology Hospital of the Chinese Academy of Medical Sciences, Tianjin

430023

NOT_YET_RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

450003

RECRUITING

Henan Provincial Cancer Hospital, Zhengzhou

510080

NOT_YET_RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

510515

NOT_YET_RECRUITING

Nanfang Hospital of Southern Medical University, Guangzhou

Sponsors
All Listed Sponsors
lead

Ascentage Pharma Group Inc.

INDUSTRY

NCT06319456 - A Global Study of Lisaftoclax (APG-2575) Combined With Acalabrutinib Versus Immunochemotherapy for Newly Diagnosed CLL/SLL. | Biotech Hunter | Biotech Hunter