APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

December 23, 2021

Primary Completion Date

September 1, 2024

Study Completion Date

December 1, 2024

Conditions
Multiple MyelomaAmyloidosis
Interventions
DRUG

APG-2575+ Pd

APG-2575 + Pomalidomide 4mg QD x 21 days + dexamethasone (40 mg for patients ≤ 75 years old or 20 mg for patients \> 75 years old) on Days 1, 8, 15, and 22 of a repeated 28-day cycle

DRUG

APG-2575 + DRd

APG-2575+ Lenalidomide administered at a dose of 25 mg orally (PO) on Days 1 through 21 of each 28-day cycle, dexamethasone will be administered at a dose of 40 mg (or 20 mg for patients \> 75 years old) once weekly, and daratumumab will be administered intravenously at a dose of 16 mg/kg (or 1800 mg administered subcutaneously if commercially available) weekly in cycles 1 and 2 and then every 2 weeks in cycles 3 to 6 and every 4 weeks thereafter.

Trial Locations (3)

10065

RECRUITING

Weil Cornell Medical Center, New York

32224

RECRUITING

Mayo Clinic, Jacksonville

44103

RECRUITING

Cleveland Clinic Hosptials, Cleveland

Sponsors
All Listed Sponsors
lead

Ascentage Pharma Group Inc.

INDUSTRY