108
Participants
Start Date
December 23, 2021
Primary Completion Date
September 1, 2024
Study Completion Date
December 1, 2024
APG-2575+ Pd
APG-2575 + Pomalidomide 4mg QD x 21 days + dexamethasone (40 mg for patients ≤ 75 years old or 20 mg for patients \> 75 years old) on Days 1, 8, 15, and 22 of a repeated 28-day cycle
APG-2575 + DRd
APG-2575+ Lenalidomide administered at a dose of 25 mg orally (PO) on Days 1 through 21 of each 28-day cycle, dexamethasone will be administered at a dose of 40 mg (or 20 mg for patients \> 75 years old) once weekly, and daratumumab will be administered intravenously at a dose of 16 mg/kg (or 1800 mg administered subcutaneously if commercially available) weekly in cycles 1 and 2 and then every 2 weeks in cycles 3 to 6 and every 4 weeks thereafter.
RECRUITING
Weil Cornell Medical Center, New York
RECRUITING
Mayo Clinic, Jacksonville
RECRUITING
Cleveland Clinic Hosptials, Cleveland
Lead Sponsor
Ascentage Pharma Group Inc.
INDUSTRY