Small Molecules
Total Trials
41
As Lead Sponsor
39
As Collaborator
2
Total Enrollment
108,333
NCT00007020
Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid
Phase: Phase 3
Role: Lead Sponsor
Start: Jan 31, 1992
Completion: Dec 31, 2009
NCT01438411
Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis
Start: Jan 31, 2010
Completion: Jul 31, 2016
NCT01115582
Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis
Start: Apr 30, 2010
Completion: Aug 31, 2010
NCT01649245
Hansenula-derived Pegylated Interferon in Treatment of Patients With Chronic Hepatitis C
Phase: Phase 4
Start: Aug 31, 2012
Completion: Aug 31, 2014
NCT01896609
Trial Comparing the Efficacy, Tolerability and Safety Between Three Arms in Treatment of HCV in Egyptian Population
Start: Jun 30, 2013
Completion: Jun 30, 2015
NCT01903460
Safety and Efficacy Study of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Alagille Syndrome
Phase: Phase 2
Start: Aug 31, 2013
Completion: Mar 31, 2015
NCT01904058
Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis
Completion: Apr 30, 2015
NCT01960569
Topical r-Hirudin ( Thrombexx ) Efficacy in Treatment of Haematomas
Start: Oct 31, 2013
Completion: Apr 30, 2014
NCT02047318
An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome (ALGS)
Start: Dec 20, 2013
Completion: Jun 17, 2020
NCT02057718
Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis
Start: Mar 1, 2014
Completion: May 8, 2020
NCT02061540
Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis
Start: Mar 31, 2014
Completion: Feb 29, 2016
NCT02131623
Validation of the Itch Reported Outcome (ItchRO) Diaries in Pediatric Cholestatic Liver Disease
Phase: N/A
Start: Jul 31, 2014
NCT02160782
Safety and Efficacy Study of LUM001 (Maralixibat) With a Drug Withdrawal Period in Participants With Alagille Syndrome (ALGS)
Start: Oct 28, 2014
Completion: May 28, 2020
NCT02057692
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome
Start: Nov 24, 2014
Completion: Nov 16, 2016
NCT02287779
Safety and Tolerability Study of SHP626 in Overweight and Obese Adults
Phase: Phase 1
Start: Jan 19, 2015
Completion: Jun 19, 2015
NCT02117713
An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Pediatric Subjects With Alagille Syndrome
Start: Mar 16, 2015
Completion: Jun 1, 2020
NCT02321306
An Open-label Study to Evaluate the Long-term Safety and Tolerability of LUM001 in Patients With Primary Biliary Cirrhosis
Start: May 31, 2015
Completion: Mar 31, 2018
NCT02475317
Study to Assess the Relative Potency of Multiple Oral Doses of LUM001 and SHP626 in Overweight and Obese Adults as Assessed by Fecal Bile Acid Excretion
Start: Jun 1, 2015
Completion: Dec 1, 2015
NCT02571192
A Study to Investigate How the Study Drug SHP626 is Eliminated From the Body After One Dose
Start: Oct 1, 2015
Completion: Oct 1, 2015
NCT02787304
Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)
Start: Oct 24, 2016
Completion: Jul 27, 2018
NCT03057574
Gonapure® in Multifollicular Stimulation in Egyptian Women Undergoing IVF/ICSI
Start: Feb 9, 2017
Completion: Jan 31, 2018
NCT04039958
A Study of Sofosbuvir and Ledipasvir From Soviredia 90/400 mg Tablets (Minapharm, Egypt) Versus Harvoni 90/400 mg Tablets (Gilead Sciences, USA)
Role: Collaborator
Start: Apr 5, 2017
Completion: May 28, 2017
NCT03115086
The REPLACE Registry for Cholbam® (Cholic Acid)
Start: Jul 10, 2017
Completion: Jul 31, 2039
NCT03353454
A Placebo-controlled Study of Maralixibat (SHP625) in Pediatric Subjects With Progressive Familial Intrahepatic Cholestasis (PFIC)
Start: Oct 25, 2018
Completion: Jun 15, 2020
NCT03905330
A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)
Start: Jul 9, 2019
Completion: Sep 1, 2022
NCT04185363
An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)
Start: Jan 8, 2020
Completion: Apr 23, 2025
NCT04168385
MRX-800: A Long-Term Safety Study of Maralixibat in the Treatment of Cholestatic Liver Disease in Subjects Who Previously Participated in a Maralixibat Study
Start: Jan 16, 2020
Completion: Sep 4, 2024
NCT04270682
Study to Evaluate Patients With Cerebrotendinous Xanthomatosis (RESTORE)
Start: Jan 31, 2020
Completion: Oct 4, 2023
NCT04663308
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
Start: Dec 18, 2020
Completion: Apr 30, 2027
NCT04718961
A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA)
Start: Jan 4, 2021
Completion: Dec 7, 2022
NCT05368038
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
Start: May 10, 2021
Completion: Aug 31, 2029
NCT04524390
Evaluation of Maralixibat in Biliary Atresia Response Post-Kasai
Start: Jul 8, 2021
Completion: Feb 7, 2024
NCT05863832
Study to Assess the Safety & Efficacy of Oral Ciprodiazole Versus Currently Used Ciprofloxacin & Metronidazole
Start: Aug 17, 2021
Completion: Dec 31, 2023
NCT04729751
A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).
Start: Sep 9, 2021
Completion: Dec 17, 2024
NCT05050136
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
Start: Sep 22, 2021
Completion: Jul 31, 2027
NCT05849558
Study to Compare the Efficacy & Safety of Ursoplus Capsules vs. UDCA vs. Placebo Among Chronic Liver Disease Patients
Start: Feb 22, 2022
NCT05847205
Study Evaluation of Recombinant Hirudin in Prophylaxis of Post-Operative Deep Vein Thrombosis
Start: Nov 24, 2022
NCT06193928
Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)
Start: Sep 21, 2023
Completion: Sep 20, 2030
NCT06553768
Evaluation of Maralixibat in Pruritus Associated With General Cholestatic Liver Disease (EXPAND)
Start: Oct 14, 2024
Completion: Feb 28, 2027
NCT07209462
Study of MRM-3379 in Male Participants With Fragile X Syndrome
Start: Dec 31, 2025
Completion: Oct 31, 2027
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