An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome (ALGS)

PHASE2CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

December 20, 2013

Primary Completion Date

June 17, 2020

Study Completion Date

June 17, 2020

Conditions
Alagille Syndrome
Interventions
DRUG

LUM001 (Maralixibat)

Dosing of LUM001 also known as Maralixibat (MRX) with the objective of achieving optimal control of pruritus at a dose level that is tolerated by the participant and up to a maximum daily dose of 560 micrograms per kilogram (mcg/kg).

Trial Locations (3)

B4 6NH

Birmingham Children's Hospital, Birmingham

LS1 3EX

Leeds Teaching Hospital NHS Trust, Leeds

SE5 9RS

Kings College Hospital, London

Sponsors
All Listed Sponsors
lead

Mirum Pharmaceuticals, Inc.

INDUSTRY