Oral drugs
Total Trials
41
As Lead Sponsor
39
As Collaborator
2
Total Enrollment
6,614
NCT02549937
A Multi-Center, Open-Label Study of Surufatinib (HMPL-012) in Patients With Advanced Solid Tumors
Phase: Phase 1/2
Role: Lead Sponsor
Start: Nov 30, 2015
Completion: Jun 2, 2023
NCT04005066
A Phase IV Study of Elunate® (Fruquintinib) in Chinese Patients
Phase: N/A
Start: Apr 20, 2019
Completion: Sep 27, 2022
NCT03903705
: A Phase Ib/II Study To Evaluate Fruquintinib Monotherapy Or Plus Sintilimab In Advanced Solid Tumors
Start: Apr 25, 2019
Completion: Dec 16, 2024
NCT03786926
Trial to Evaluate the Safety and Pharmacokinetics of HMPL-689 in Patients With Lymphomas
Phase: Phase 1
Start: Aug 26, 2019
Completion: Jun 26, 2024
NCT03779113
An Open-label, Dose Escalation Trial to Evaluate the Safety and Pharmacokinetics of HMPL-523 in Patients With Lymphoma
Start: Sep 26, 2019
Completion: Mar 19, 2025
NCT03778034
Effect of Forward Head Posture(FHP)on Temopromandibular Joint (TMJ) Proprioception in Post-pubertal Females
Start: Oct 1, 2019
Completion: Dec 15, 2019
NCT04353375
Phase 2 Study of HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma
Phase: Phase 2
Start: Sep 3, 2020
Completion: Dec 31, 2025
NCT04762602
A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations
Start: Feb 28, 2021
Completion: Feb 27, 2025
NCT04764474
A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH
Completion: Jan 15, 2025
NCT04579757
Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors
Start: Mar 5, 2021
Completion: Aug 27, 2024
NCT04908046
A Study of HMPL-295S1 in Patients With Advanced Malignant Solid Tumors
Start: May 27, 2021
Completion: Feb 23, 2024
NCT04577963
A Study of Fruquintinib in Combination With Tislelizumab in Advanced Solid Tumors
Start: Aug 9, 2021
Completion: Jun 18, 2024
NCT04579679
Open-Label Surufatinib in European Patients With NET
Start: Aug 13, 2021
Completion: Oct 15, 2024
NCT05077384
Open-label Study of Surufatinib in Japanese Patients
Start: Sep 2, 2021
Completion: Jan 17, 2025
NCT05093322
A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors
Start: Nov 30, 2021
Completion: Apr 25, 2023
NCT05190068
HMPL-760 in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
Start: Jan 4, 2022
Completion: Jan 27, 2025
NCT05176691
HMPL-760 Safety and Tolerability Study in Patients With Previously Treated CLL/SLL or NHL
Start: Feb 15, 2022
Completion: Nov 16, 2022
NCT05368805
Fruquintinib DDI Study With P-gp and BCRP Substrates
Start: Mar 2, 2022
Completion: Apr 22, 2022
NCT05216354
Fruquintinib Renal Impairment Study
Start: Mar 11, 2022
Completion: Jun 26, 2023
NCT05216367
Fruquintinib Hepatic Impairment Study
Completion: Oct 25, 2022
NCT05602597
HMPL-689 Drug Interaction Study With CYP3A Inhibitor/CYP2C9 Inhibitor/CYP3A Inducer/PPI
Start: Jun 1, 2022
Completion: Aug 6, 2022
NCT05571787
HMPL-523 Food Effect and Proton Pump Inhibitor Study
Start: Jul 13, 2022
Completion: Sep 22, 2022
NCT05429008
A Phase I Clinical Study of HMPL-A83 in Patients With Advanced Malignant Neoplasm
Start: Jul 15, 2022
Completion: Apr 7, 2025
NCT05467943
Tazemetostat for the Treatment of Relapsed/Refractory Follicular Lymphoma
Start: Jul 29, 2022
Completion: Nov 30, 2024
NCT05494580
Pamiparib Plus Surufatinib in Patients With Platinum-resistant Ovarian Cancer
Role: Collaborator
Start: Sep 22, 2022
Completion: Aug 10, 2025
NCT05522231
Efficacy and Safety of Fruquintinib in Combination With Sintilimab in Advanced Renal Cell Carcinoma (FRUSICA-2)
Phase: Phase 2/3
Start: Oct 27, 2022
Completion: Mar 31, 2025
NCT05720767
HMPL-523 CYP3A/P-gp Inhibitor and CYP Inducer Study
Start: Nov 4, 2022
Completion: Feb 5, 2023
NCT05781906
Human Mass Balance of [14C]HMPL-523 in Healthy Adult Male Chinese Subjects
Start: Feb 8, 2023
Completion: Dec 6, 2023
NCT05713110
A Study of Tazemetostat in Combination With HMPL-689 in Patients With Relapsed/Refractory Lymphoma
Start: Feb 13, 2023
Completion: Dec 31, 2024
NCT05930119
HMPL-453 Food Effect and PPI Study in Healthy Volunteer Study
Start: Mar 17, 2023
Completion: Aug 28, 2023
NCT05886374
A Study of HMPL-415S1 in Patients With Advanced Malignant Solid Tumors
Start: Jul 6, 2023
Completion: Jun 30, 2026
NCT06291415
The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)
Start: Apr 2, 2024
Completion: Nov 30, 2026
NCT06387069
A Study to Evaluate HMPL-306 in Patients With IDH1or IDH2-mutated Acute Myeloid Leukemia
Phase: Phase 3
Start: Apr 26, 2024
Completion: Sep 30, 2029
NCT06361888
A Phase II/III Trial to Evaluate the Efficacy and Safety of Surufatinib Combined With Camrelizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer
Start: May 8, 2024
Completion: Aug 31, 2027
NCT06387082
A Clinical Study of HMPL-506 in Patients With Hematological Malignancies
Start: May 27, 2024
Completion: Dec 8, 2027
NCT06601504
Study of HMPL-760 Plus R-GemOx Versus Placebo Plus R-GemOx in Relapsed/Refractory DLBCL
Start: Nov 5, 2024
Completion: Nov 12, 2026
NCT06671873
Study on Mass Balance of [14C]HMPL-306(Isocitrate Dehydrogenase Inhibitor) in Healthy Chinese Adult Male Subjects
Start: Nov 26, 2024
Completion: Jul 2, 2025
NCT06584032
Study of Fruquintinib Plus Sintilimab for Treatment of Advanced Endometrial Cancer
Start: Dec 12, 2024
Completion: Jun 9, 2029
NCT07025018
Phase I Study of HMPL-306 for the Treatment of Gliomas With IDH1 and/or IDH2 Mutations
Start: Jul 15, 2025
Completion: Dec 31, 2027
NCT05690035
Tislelizumab Combined With Fruquintinib for Metastatic pMMR/MSS Colorectal Cancer
Start: Jul 31, 2025
Completion: Jul 31, 2025
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