Study of HMPL-760 Plus R-GemOx Versus Placebo Plus R-GemOx in Relapsed/Refractory DLBCL

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

November 5, 2024

Primary Completion Date

May 12, 2026

Study Completion Date

November 12, 2026

Conditions
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Interventions
DRUG

HMPL-760 planned dose 1

HMPL-760 planned dose 1 daily (QD) orally

DRUG

R-GemOx

R-GemOx regimen includes Rituximab Injection, Gemcitabine Hydrochloride for Injection, Gemcitabine Hydrochloride for Injection. R-GemOx regimen in 21-day cycle for a total of 6 cycles. Rituximab 375 mg/m\^2 ivgtt is given on day 1 of each cycle, and gemcitabine 1000 mg/m\^2 ivgtt is given, followed by oxaliplatin 100 mg/m\^2 ivgtt on day 2 of each cycle.

DRUG

HMPL-760 placebo planned dose 1

HMPL-760 placebo planned dose 1 daily (QD) orally

DRUG

HMPL-760 planned dose 2

HMPL-760 planned dose 2 daily (QD) orally

DRUG

HMPL-760 placebo planned dose 2

HMPL-760 placebo planned dose 2 daily (QD) orally

Trial Locations (16)

Unknown

Fujian Medical University Union Hospital, Fuzhou

Sun Yat-sen University Cancer Center, Guangzhou

Guangxi Medical University Cancer Hospital, Nanning

Wuhan Union Hospital of China, Wuhan

Harbin First Hospital, Harbin

Harbin Medical University Cancer Hospital, Harbin

Henan Cancer Hospital, Zhengzhou

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Hunan Cancer Hospital, Changsha

Jiangxi Cancer Hospital, Nanchang

The First Affiliated Hospital of Nanchang University, Nanchang

Shengjing Hospital of China Medical University, Shenyang

Shandong Cancer Hospital & Institute, Jinan

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

West China Hospital of Sichuan University, Chengdu

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Hutchmed

INDUSTRY

NCT06601504 - Study of HMPL-760 Plus R-GemOx Versus Placebo Plus R-GemOx in Relapsed/Refractory DLBCL | Biotech Hunter | Biotech Hunter