Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

87

Participants

Timeline

Start Date

March 5, 2021

Primary Completion Date

April 30, 2024

Study Completion Date

August 27, 2024

Conditions
Metastatic Solid TumorColorectal CancerNeuroendocrine TumorsSmall Cell Lung CancerGastric CancerSoft Tissue SarcomaAnaplastic Thyroid Cancer
Interventions
DRUG

Surufatinib and Tislelizumab _ Part 1

Part 1 (all cohorts): oral surufatinib at a dose based on cohort level and intravenous tislelizumab at a 200-mg dose

DRUG

Surufatinib and Tislelizumab _ Part 2

Part 2 (all cohorts): oral surufatinib at the RP2D dose selected in Part 1 and intravenous tislelizumab at a 200-mg dose

Trial Locations (18)

10021

Memorial Sloan Kettering Cancer Center, New York

19104

University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia

20016

Johns Hopkins University - Sibley Memorial Hospital, Washington D.C.

22031

Virginia Cancer Specialists, PC, Fairfax

29605

Prisma Health - Upstate (ITOR), Greenville

30322

Emory University - Winship Cancer Institute, Atlanta

37203

Sarah Cannon, Nashville

37232

Vanderbilt University Medical Center, Nashville

44106

University Hospitals Cleveland Medical Center, Cleveland

52242

Holden Comprehensive Cancer Center, University of Iowa, Iowa City

75230

Mary Crowley Cancer Research, Dallas

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75702

Texas Oncology, P.A., Tyler

76104

Texas Oncology, P.A., Fort Worth

77079

The University of Texas MD Anderson Cancer Center, Houston

80218

Rocky Mountain Cancer Centers Midtown, Denver

85711

Arizona Oncology Associated, PC-HOPE, Tucson

91010

City of Hope, Duarte

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

BeiGene

INDUSTRY

lead

Hutchmed

INDUSTRY

NCT04579757 - Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter