HMPL-523 CYP3A/P-gp Inhibitor and CYP Inducer Study

HMPL-523 is a selective small-molecule SYK inhibitor.

Itraconazole is an FDA approved synthetic triazole antifungal agent

Rifampin is an FDA approved semisynthetic antiobiotic derivative indicated in the treatment of both tuberculosis and meningococcal carrier state