316
Participants
Start Date
April 26, 2024
Primary Completion Date
December 31, 2028
Study Completion Date
September 30, 2029
HMPL-306 Regimen
Patients will receive HMPL-306 monotherapy: HMPL-306 PO at 250 mg QD (C1) + 150 mg QD (starting from C2), 28 days as a cycle.
Salvage Chemotherapy Regimen
"Patients in this regimen will receive treatment with one of the following regimens, and the regimen will be selected by the investigator based on the patient's condition:~* EA±Mitox regimen: etoposide injection 100 mg/m2, cytarabine injection 100-150 mg/m2, mitoxantrone injection 8 mg/m2 QD IV for 5 consecutive days (Days 1-5).~* FLAG ± Ida regimen: G-CSF injection 300 mcg/m2 QD SC for 5 consecutive days (Days 1-5); fludarabine injection 30 mg/m2 QD IV for 5 consecutive days (Days 2-6); cytarabine injection 1000-2000 mg/m2 QD IV for 5 consecutive days (Days 2-6); idarubicin injection 10 mg/m2 QD IV for 3 consecutive days (Days 2-4).~* LoDAC: -Cytarabine Injection 20 mg every 12 hours, subcutaneous or IV for 10 consecutive days (Days 1-10).~* Azacitidine: Azacitidine Injection 75 mg/m2, QD, subcutaneous or IV for 7 consecutive days (Days 1-7)."
RECRUITING
Peking University People's Hospital, Beijing
RECRUITING
The First Hospital of China Medical University, Shenyang
RECRUITING
Shengjing Hospital of China Medical University, Shenyang
RECRUITING
The First Hospital of Jilin University, Changchun
RECRUITING
Harbin First Hospital, Harbin
RECRUITING
Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai
RECRUITING
Tongji Hospital of Tongji University, Shanghai
RECRUITING
Nanjing Drum Tower Hospital, Nanjing
RECRUITING
Jiangsu Province Hospital, Nanjing
RECRUITING
Wuxi People's Hospital, Wuxi
RECRUITING
The First Affiliated Hospital of Soochow University, Suzhou
RECRUITING
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
RECRUITING
Anhui Provincial Hospital（The First Affiliated Hospital of U STC）, Hefei
RECRUITING
The First Affiliated Hospital of Anhui Medical University, Hefei
RECRUITING
The Second Hospital of Anhui Medical University, Hefei
RECRUITING
Qilu Hospital of Shandong University, Jinan
RECRUITING
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin
RECRUITING
Tianjin People's Hospital, Tianjin
RECRUITING
The First Affiliated Hospital, Zhejiang University, Hangzhou
RECRUITING
The First Affiliated Hospital of WMU, Wenzhou
RECRUITING
The First Affiliated Hospital of Nanchang University, Nanchang
RECRUITING
Fujian Medical University Union Hospital, Fuzhou
RECRUITING
The First Affilated Hospital of Fujian Medical University, Fuzhou
RECRUITING
The First Affiliated Hospital of Xiamen University, Xiamen
RECRUITING
Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou
RECRUITING
The First Affiliated Hospital of Chongqing Medical University, Chongqing
RECRUITING
People's Hospital of Hunan Province, Changsha
RECRUITING
Xiangya Hospital Central South University, Changsha
RECRUITING
The Third Xiangya Hospital of Central South University, Changsha
RECRUITING
Wuhan Union Hospital of China, Wuhan
RECRUITING
Zhongnan Hospital of Wuhan University, Wuhan
RECRUITING
The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou
RECRUITING
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
RECRUITING
The First Affilated Hospital of Henan University of Science & Technology, Luoyang
RECRUITING
Sun Yat-sen University Cancer Center, Guangzhou
RECRUITING
Guangzhou First People's Hospital, Guangzhou
RECRUITING
Nanfang Hospital，Southern Medical University, Guanzhou
RECRUITING
Shenzhen Second People's Hospital, Shenzhen
RECRUITING
Affiliated Hospital of Guangdong Medical University, Zhanjiang
RECRUITING
The First Affiliated Hospital of Guangxi Medical University, Nanning
RECRUITING
Guizhou Provincial People's Hospital, Guiyang
RECRUITING
The Affiliated Hospital of Guizhou Medical University, Guiyang
RECRUITING
Affiliated Hospital of Zunyi Medical Univercity, Zunyi
RECRUITING
West China Hospital of Sichuan University, Chengdu
RECRUITING
Sichuan Provincial People's Hospital, Chengdu
RECRUITING
The second people's hospital of Yibin, Yibin
RECRUITING
The First Affiliated Hospital of Kunming Medical University, Kunming
RECRUITING
The First People's Hospital of Yunnan Province, Kunming
RECRUITING
The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hosiptal), Xi'an
RECRUITING
XinjiangUiger Municipal People's Hospital, Ürümqi
RECRUITING
Baoding NO.1 Central Hospital, Baoding
RECRUITING
Affiliated Hospital of Chengde Medical University, Chengde
RECRUITING
The Second Hospital of Hebei Medical University, Shijiazhuang
Lead Sponsor
Hutchmed
INDUSTRY