Utrophin modulation technology
Total Trials
25
As Lead Sponsor
10
As Collaborator
15
Total Enrollment
4,158
NCT02056808
A Phase 1b Study of SMT C1100 in Subjects With Duchenne Muscular Dystrophy (DMD)
Phase: Phase 1
Role: Lead Sponsor
Start: Nov 30, 2013
Completion: Jul 31, 2014
NCT02092935
A Study of SMT19969 Compared With Vancomycin for the Treatment of Clostridium Difficile-Associated Diarrhoea (CDAD)
Phase: Phase 2
Start: Apr 30, 2014
Completion: Oct 31, 2015
NCT02784002
A Study of Ridinilazole (SMT19969) Compared With Fidaxomicin for the Treatment of Clostridium Difficile Infection (CDI)
Start: Dec 31, 2014
Completion: Aug 31, 2016
NCT02383511
Modified Diet Trial: A Study of SMT C1100 in Paediatric Patients With DMD Who Follow a Balanced Diet
Start: Feb 28, 2015
Completion: Aug 31, 2015
NCT02858362
Proof of Concept Study to Assess Activity and Safety of SMT C1100 (Ezutromid) in Boys With Duchenne Muscular Dystrophy (DMD)
Start: Jun 30, 2016
Completion: Sep 11, 2018
NCT03595553
Comparison of Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile Infection
Phase: Phase 3
Start: Jan 28, 2019
Completion: Nov 17, 2021
NCT04802837
Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects
Start: May 19, 2021
Completion: Sep 28, 2022
NCT05382442
A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer
Role: Collaborator
Start: Jun 27, 2022
Completion: Aug 12, 2028
NCT06396065
Phase III Study of AK112 for NSCLC Patients
Start: May 4, 2023
Completion: Dec 31, 2025
NCT05899608
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Start: Oct 26, 2023
Completion: Dec 31, 2028
NCT06567314
Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma
Start: Dec 2, 2024
Completion: Sep 1, 2030
NCT06672575
A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma
Phase: Phase 1/2
Start: Jan 30, 2025
Completion: Jan 31, 2030
NCT06805617
A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers
Start: Feb 26, 2025
Completion: Jul 1, 2027
NCT06767514
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
Start: Feb 27, 2025
Completion: Jun 30, 2029
NCT06925724
A Study of Ivonescimab in People With Endometrial and Cervical Cancers
Start: Apr 4, 2025
Completion: Apr 4, 2027
NCT06529718
Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients
Start: Jun 30, 2025
Completion: Jan 30, 2029
NCT06840834
Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy
Completion: Mar 31, 2028
NCT06940518
Phase II Trial of Ivonescimab in Previously Treated Patients With Advanced Clear Cell Renal Cell Carcinoma
Start: Jul 2, 2025
Completion: Jan 19, 2030
NCT06980077
Ivonescimab for the Treatment of Thymic Cancer
Start: Jul 15, 2025
Completion: Jun 17, 2028
NCT07017673
Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer
Start: Jul 25, 2025
Completion: Nov 30, 2032
NCT06959550
Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
Start: Jul 28, 2025
Completion: Jul 1, 2030
NCT06846346
Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma
Start: Sep 30, 2025
Completion: Sep 30, 2028
NCT07094685
Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer
Start: Nov 1, 2025
Completion: Nov 1, 2030
NCT07070466
Ivonescimab in Comb. With FOLFOX in Advanced HER2 Neg. GEA
Start: Dec 12, 2025
Completion: Sep 1, 2028
NCT07057791
Phase II Study of Platinum/Etoposide Plus Ivonescimab for Extensive-Stage Small Cell Lung Cancer
Start: Dec 31, 2025
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