Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy

PHASE2RecruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

June 30, 2025

Primary Completion Date

March 24, 2026

Study Completion Date

March 31, 2028

Conditions
Pleural Mesotheliomas
Interventions
DRUG

Ivonescimab

Ivonescimab is administered IV Q3W on Day 1 of each cycle. Ivonescimab is given at a dose of 20 mg/kg (a fixed dose of 3200 mg for ivonescimab should be used for patients ≥160 kg). The total duration of ivonescimab treatment is up to 24 months.

Trial Locations (20)

Unknown

NOT_YET_RECRUITING

Besançon - CHU, Besançon

NOT_YET_RECRUITING

Brest - CHU, Brest

ACTIVE_NOT_RECRUITING

Caen - CHU, Caen

NOT_YET_RECRUITING

Clermont-Ferrand - Centre Jean Perrin, Clermont-Ferrand

ACTIVE_NOT_RECRUITING

Créteil - CHI, Créteil

ACTIVE_NOT_RECRUITING

Grenoble - CHU, Grenoble

ACTIVE_NOT_RECRUITING

Le Mans - CHG, Le Mans

RECRUITING

Lille - CHU, Lille

ACTIVE_NOT_RECRUITING

Marseille - APHM, Marseille

RECRUITING

Montpellier - CHU, Montpellier

ACTIVE_NOT_RECRUITING

Mulhouse - GHRMSA, Mulhouse

RECRUITING

Nantes - Hôpital Laennec, Nantes

ACTIVE_NOT_RECRUITING

Paris - Bichat, Paris

ACTIVE_NOT_RECRUITING

Bordeaux - CHU, Pessac

RECRUITING

Lyon - HCL, Pierre-Bénite

RECRUITING

Strasbourg - Nouvel Hôpital Civil, Strasbourg

ACTIVE_NOT_RECRUITING

Toulon - CHI, Toulon

ACTIVE_NOT_RECRUITING

Toulouse - CHU, Toulouse

RECRUITING

Tours - CHU, Tours

NOT_YET_RECRUITING

Metz - Hôpital Robert Schuman, Vantoux

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Summit Therapeutics

INDUSTRY

lead

Intergroupe Francophone de Cancerologie Thoracique

OTHER

NCT06840834 - Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy | Biotech Hunter | Biotech Hunter