Testing Ivonescimab in Combination With Chemotherapy in Advanced or Metastatic Gastric/Gastroesophageal Adenocarcinoma

Ivonescimab 20 mg/kg by intravenous (IV) infusion once every 2 weeks until disease progression.

Oxaliplatin 85 mg/m2 IV, folinic acid 400 mg/m2 IV (or L-folinic acid 200 mg/m²), and fluorouracil (5-FU) 400 mg/m² IV bolus; followed by 5 FU 2400 mg/m2 as a 46 hour continuous IV infusion, every two weeks for 8 cycles followed by 5FU as maintenance therapy until disease progression.

180 mg/ m2 IV over 90 min infusion every two weeks for a minimum of 4 cycles

80 mg/m2 IV at D1, D8 and D15, every four weeks (D1=D28)