Defunct Company
Total Trials
15
As Lead Sponsor
14
As Collaborator
1
Total Enrollment
2,506
NCT04004507
Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances
Phase: Phase 2
Role: Lead Sponsor
Start: Aug 31, 2007
Completion: Feb 29, 2008
NCT01703559
The Safety and Efficacy of Phentolamine Mesylate Ophthalmic Solution in Subjects With Severe Night Vision Disturbances
Start: Sep 9, 2011
Completion: Apr 30, 2012
NCT03960866
Safety and Efficacy of Ophthalmic Phentolamine Mesylate in Glaucoma
Start: May 28, 2019
Completion: Sep 11, 2019
NCT04024891
Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis
Start: Aug 13, 2019
Completion: Sep 17, 2019
NCT04620213
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis
Phase: Phase 3
Start: Nov 18, 2020
Completion: Mar 15, 2021
NCT04638660
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) in Subjects With Dim Light Vision Disturbances
Start: Dec 30, 2020
Completion: May 19, 2022
NCT04675151
Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia
Start: Feb 15, 2021
Completion: Jun 30, 2021
NCT04692688
Study of the Safety and Efficacy of APX3330 in Diabetic Retinopathy
Start: Apr 8, 2021
Completion: Jan 25, 2023
NCT05134974
Safety and Efficacy of Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis (MIRA-3)
Start: Nov 18, 2021
Completion: Mar 29, 2022
NCT05223478
Nyxol (0.75% Phentolamine Ophthalmic Solution) to Reverse Pharmacologically-Induced Mydriasis in Pediatric Subjects
Start: Dec 17, 2021
Completion: Apr 28, 2022
NCT05646719
Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia
Start: Dec 22, 2022
Completion: Oct 11, 2023
NCT06349759
Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Start: Apr 1, 2024
Completion: Jan 31, 2026
NCT06542497
Evaluate Efficacy and Safety of POS to Improve Distance-corrected Near Visual in Participants With Presbyopia
Start: Aug 15, 2024
Completion: May 31, 2026
NCT06892951
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
Phase: Phase 1/2
Role: Collaborator
Start: Jun 30, 2025
Completion: Dec 31, 2028
NCT07140783
OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity
Start: Sep 2, 2025
Completion: Mar 31, 2026