Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia

PHASE3CompletedINTERVENTIONAL
Enrollment

333

Participants

Timeline

Start Date

December 22, 2022

Primary Completion Date

October 11, 2023

Study Completion Date

October 11, 2023

Conditions
Presbyopia
Interventions
DRUG

Phentolamine Opthalmic Solution 0.75%

phentolamine ophthalmic solution 0.75% (Nyxol), a non-selective alpha-1 and alpha-2 adrenergic antagonist

OTHER

Placebo

Vehicle for Phentolamine Ophthalmic Solution

DRUG

Low dose pilocarpine

Pilocarpine hydrochloride ophthalmic solution 0.4%

OTHER

Low dose pilocarpine vehicle

Vehicle for low dose pilocarpine

Trial Locations (26)

11787

Smithtown, NY, Smithtown

14618

Rochester, NY, Rochester

16066

Cranberry Township, PA, Cranberry Township

17349

New Freedom, PA, New Freedom

27529

Garner, NC, Garner

30076

Roswell, GA, Roswell

32779

Longwood, FL, Longwood

33484

Delray Beach, FL, Delray Beach

38119

Memphis, TN, Memphis

45701

Athens, OH, Athens

55420

Bloomington, MN, Bloomington

57108

Sioux Falls, SD, Sioux Falls

58103

Fargo, ND, Fargo

60046

Lake Villa, IL, Lake Villa

63017

Chesterfield, MO, Chesterfield

63128

Saint Louis, MO, St Louis

64133

Kansas City, MO, Kansas City

66204

Shawnee Mission, KS, Shawnee Mission

66762

Pittsburg, KS, Pittsburg

73301

Austin, TX, Austin

77055

Houston, TX, Houston

78229

San Antonio, TX, San Antonio

85003

Phoenix, AZ, Phoenix

91325

Northridge, CA, Northridge

91702

Azusa, CA, Azusa

92663

Newport Beach, CA, Newport Beach

Sponsors
All Listed Sponsors
lead

Ocuphire Pharma, Inc.

INDUSTRY

NCT05646719 - Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia | Biotech Hunter | Biotech Hunter