Small Molecules
Total Trials
75
As Lead Sponsor
69
As Collaborator
6
Total Enrollment
7,988
NCT00105105
Mifepristone as Adjunctive Therapy in Alzheimer's Disease
Phase: Phase 2
Role: Lead Sponsor
Start: Apr 30, 2003
Completion: Nov 30, 2005
NCT00128479
A United States Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Phase: Phase 3
Start: Sep 30, 2004
Completion: Jan 31, 2007
NCT00130676
A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depression
Completion: Jun 30, 2006
NCT00146523
An International Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Start: May 31, 2005
Completion: Jul 31, 2006
NCT00208156
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Completion: Nov 30, 2006
NCT00128505
An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Start: Aug 31, 2005
NCT00455442
A Two-Week Study of the Efficacy and Safety of Mifepristone in the Prevention of Olanzapine-Induced Weight Gain
Start: Mar 31, 2007
Completion: Jul 31, 2007
NCT00569582
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Start: Dec 31, 2007
Completion: Not specified
NCT00637494
A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features
Start: Mar 31, 2008
Completion: Jun 30, 2014
NCT00752843
A Phase I Study to Determine the Effect of Mifepristone on the Pharmacokinetics of Fluvastatin in Healthy Volunteers
Phase: Phase 1
Start: Sep 30, 2008
Completion: Nov 30, 2008
NCT00698022
A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers
Start: Nov 30, 2008
Completion: Feb 28, 2009
NCT00796783
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
Phase: N/A
Start: Feb 28, 2009
NCT00936741
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Start: Jul 31, 2009
Completion: Sep 30, 2012
NCT01371565
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome
Start: Nov 30, 2010
NCT01925092
Mifepristone in Children With Refractory Cushing's Disease
Start: Aug 31, 2013
NCT02014337
Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors
Start: Jan 31, 2014
Completion: Dec 31, 2017
NCT03508635
CORT125134 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
Start: Sep 30, 2014
Completion: Dec 31, 2015
NCT02663609
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome
Start: Oct 31, 2015
Completion: Dec 1, 2017
NCT02642939
Study of Oral Mifepristone as Salvage Therapy in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer
Role: Collaborator
Start: Dec 31, 2015
Completion: Oct 15, 2020
NCT06094712
A Study to Evaluate the Pharmacokinetics of the CORT125134 Phase 2 Formulation in Healthy Male Subjects
Start: Apr 7, 2016
Completion: Apr 27, 2016
NCT02762981
Study to Evaluate Relacorilant (CORT125134) in Combination With Nab-paclitaxel in Participants With Solid Tumors
Phase: Phase 1/2
Start: May 23, 2016
Completion: Sep 12, 2020
NCT02804750
Study to Evaluate CORT125134 in Participants With Cushing's Syndrome
Start: Jun 30, 2016
Completion: Sep 30, 2018
NCT03067376
A Study Designed to See How [14C]-CORT125134 is Taken up, Broken Down and Removed From the Body
Start: Aug 31, 2016
Completion: Sep 30, 2016
NCT02922257
Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery
Start: Nov 30, 2016
Completion: Oct 30, 2018
NCT06094790
A Study to Evaluate the Pharmacokinetics of the Current Capsule Formulation of CORT125134 in Healthy Subjects
Start: May 18, 2017
Completion: Nov 15, 2017
NCT03259542
Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor
Start: Aug 9, 2017
Completion: Dec 11, 2017
NCT03258372
Crossover Drug-Drug Interaction Study to Determine Effects of Cytochrome P450 3A on Exposure to Mifepristone and Its Metabolites
Start: Aug 16, 2017
Completion: Nov 29, 2017
NCT03315338
First-in-human Study in Healthy Subjects
Start: Sep 15, 2017
Completion: Feb 22, 2019
NCT03379363
Retrospective Chart Review Study of Pediatric Patients Treated With Korlym for Cushing Syndrome
Start: Sep 18, 2017
Completion: Feb 12, 2018
NCT03335956
CORT125281 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
Start: Sep 21, 2017
Completion: Jun 25, 2018
NCT03437941
Study to Evaluate CORT125281 in Combination With Enzalutamide in Patients With mCRPC
Start: Dec 15, 2017
Completion: Jan 9, 2023
NCT03442621
Relacorilant Food Effect Study in Healthy Subjects
Start: Jan 16, 2018
Completion: Mar 9, 2018
NCT03457597
Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s
Start: Mar 6, 2018
Completion: Apr 28, 2018
NCT03512548
Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites
Start: Apr 10, 2018
Completion: Aug 23, 2019
NCT03604198
Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
Start: May 7, 2018
Completion: Dec 31, 2025
NCT03540836
A Study to Determine the Relative Bioavailability of Two New Relacorilant Capsule Variants
Start: May 24, 2018
Completion: Jul 25, 2018
NCT03878264
Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants
Start: Aug 6, 2018
Completion: Mar 24, 2019
NCT03877952
Mass Balance Recovery and Metabolite Profile of CORT125281 in Healthy Male Participants
Start: Sep 13, 2018
Completion: Nov 2, 2018
NCT03674814
Study of Drug 1 (Enzalutamide) Plus Drug 2 (Relacorilant) for Patients With Prostate Cancer
Start: Oct 23, 2018
Completion: Mar 10, 2026
NCT03697109
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
Start: Nov 15, 2018
Completion: Apr 15, 2024
NCT03877562
The Effect of CORT118335 on Olanzapine-Induced Weight Gain
Start: Apr 1, 2019
Completion: Mar 25, 2020
NCT03776812
Study of Relacorilant in Combination With Nab-Paclitaxel for Patients With Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Start: Apr 5, 2019
Completion: Jul 12, 2023
NCT03818256
A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adults With Schizophrenia or Bipolar Disorder Treated With Antipsychotic Medications
Start: Dec 4, 2019
Completion: Jul 6, 2022
NCT06094725
A Study to Evaluate the Effects of Hepatic Impairment on the Pharmacokinetics of Relacorilant
Start: Jan 6, 2020
Completion: Dec 14, 2020
NCT04249323
Single and Multiple Ascending Dose Study of CORT113176 in Healthy Participants
Start: Jan 27, 2020
NCT04672499
Single and Multiple Dose Study of Miricorilant (CORT118335) Tablet Formulations in Healthy Participants
Start: Apr 27, 2020
Completion: Sep 7, 2020
NCT04329949
Study of Relacorilant in Combination With Nab-Paclitaxel in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Start: Jun 30, 2020
Completion: Mar 25, 2022
NCT04308590
A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
Start: Jul 27, 2020
Completion: Sep 19, 2024
NCT04524403
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II)
Start: Sep 9, 2020
Completion: Aug 25, 2022
NCT06094738
A Study to Evaluate the Effect of Food on the Oral Bioavailability of Relacorilant in Healthy Subjects
Start: Sep 19, 2020
Completion: Nov 16, 2020
NCT04373265
Study of Relacorilant in Combination With Pembrolizumab for Patients With Adrenocortical Carcinoma Which Produces Too Much Stress Hormone (Cortisol)
Start: Sep 30, 2020
Completion: Jan 12, 2024
NCT04672512
Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants
Start: Oct 23, 2020
Completion: Jan 17, 2022
NCT03823703
Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Participants With Presumed Nonalcoholic Steatohepatitis (NASH)
Start: Nov 4, 2020
Completion: Apr 5, 2021
NCT04795479
T/QT Study to Investigate the Effect of Relacorilant on Cardiac Repolarization in Healthy Volunteers
Start: Jan 22, 2021
Completion: Jul 13, 2021
NCT04588688
Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency
Start: May 5, 2021
Completion: Aug 1, 2021
NCT04994743
Safety, Tolerability, and Pharmacokinetic Study of CORT113176 in Healthy Participants
Start: Jul 13, 2021
Completion: Sep 30, 2021
NCT05003713
Single and Multiple Ascending Dose Study of CORT125236 in Healthy Participants
Start: Aug 3, 2021
Completion: Feb 3, 2023
NCT04990310
Single Dose Absorption, Distribution, Metabolism, and Excretion Study of [14C]-CORT113176 in Healthy Male Participants
Start: Aug 18, 2021
Completion: Sep 20, 2021
NCT05117489
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Patients With Presumed Nonalcoholic Steatohepatitis (NASH)
Start: Nov 23, 2021
Completion: Jan 29, 2024
NCT05217758
RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma
Start: Dec 9, 2021
Completion: Nov 12, 2024
NCT05553470
Study to Evaluate the Effects of Hepatic Impairment on the Pharmacokinetics of Miricorilant
Start: Mar 3, 2022
Completion: Sep 13, 2024
NCT05320146
A Sub Study of the Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Patients With Presumed Nonalcoholic Steatohepatitis (NASH)
Start: Mar 4, 2022
Completion: Jul 18, 2023
NCT05347979
Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants
Start: May 25, 2022
Completion: Jul 19, 2022
NCT05257408
Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer
Start: Jun 29, 2022
Completion: Mar 31, 2026
NCT05407324
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis
Start: Nov 15, 2022
Completion: May 31, 2027
NCT05712265
Study to Evaluate the Effects of a Cytochrome P450 2C19 Inhibitor on the Pharmacokinetics of Miricorilant
Start: Jan 24, 2023
Completion: Feb 23, 2023
NCT05772169
Study to Determine the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Treatment With Korlym® (Mifepristone) (CATALYST)
Phase: Phase 4
Start: Mar 31, 2023
Completion: Dec 18, 2024
NCT06099769
A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer
Start: Oct 18, 2023
Completion: Oct 31, 2027
NCT06108219
A Phase 2b, Study Evaluating Miricorilant in Adult Patients With Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH)
Start: Oct 25, 2023
Completion: Sep 30, 2026
NCT06495944
Impact of Itraconazole on the Pharmacokinetics and Safety of Dazucorilant in Healthy, Adult Participants
Start: May 31, 2024
Completion: Aug 2, 2024
NCT06928779
Effects of Hepatic Impairment on the Pharmacokinetics of Dazucorilant
Start: Oct 8, 2024
Completion: Dec 9, 2024
NCT06689254
REVERSE: Improving Treatment-resistant Post Traumatic Stress Disorder (PTSD) with Glucocorticoid Receptor (GR) Antagonism
Start: Nov 15, 2024
Completion: Nov 15, 2026
NCT06829537
Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM)
Start: Mar 28, 2025
NCT06906341
Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers
Start: Apr 11, 2025
Completion: Dec 31, 2026
NCT06947304
Evaluation of Miricorilant on Liver Fat in Patients With MASLD
Start: Aug 22, 2025
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