A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome

PHASE3CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

December 31, 2007

Primary Completion Date

January 31, 2011

Conditions
Cushing's Syndrome
Interventions
DRUG

mifepristone

Patients take mifepristone by mouth once a day. The dose is increased during scheduled timepoints during the study or until symptoms improve or the highest dosage allowed is reached. Dose escalation will be based upon weight. During clinic visits, blood pressure, glucose tolerance and blood chemistries are measured and EKG and urinalysis will be performed.

Trial Locations (17)

21215

Sinai Hospital of Baltimore, Baltimore

33021

The Center for Diabetes and Endocrine Care, Hollywood

35294

University of Alabama at Birmingham School of Medicine, Birmingham

39216

University of Mississippi Medical Center, Jackson

44195

Cleveland Clinic Foundation; Dept of Endocrinology, Diabetes & Metabolism, Cleveland

48109

University of Michigan Medical Center, Ann Arbor

53051

Endocrinology Center at North Hills, Froedtert and Medical College of Wisconsin, Menomonee Falls

60611

Northwestern University Feinberg Medical; Division of Endocrinology, Metabolism & Molecular Medicine, Chicago

60637

The University of Chicago, Chicago

73104

Oklahoma University Health Science Center, Oklahoma City

75390

University of Texas Southwestern Medical Center, Dallas

78229

Diabetes and Glandular Disease Clinic, San Antonio

87131

University of New Mexico HSC, Albuquerque

92026

AMCR Institute Inc., Escondido

97239

Oregon Health Sciences University, Portland

94305-5826

Stanford University Medical Center, Stanford

02114

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
lead

Corcept Therapeutics

INDUSTRY