NCT03315338 - First-in-human Study in Healthy Subjects | Biotech Hunter

Enrollment

143

Participants

Timeline

Start Date

September 15, 2017

Primary Completion Date

February 22, 2019

Study Completion Date

February 22, 2019

Conditions

Healthy

Interventions

DRUG

CORT118335, 25 mg

CORT118335 is supplied as capsules for oral dosing

DRUG

Prednisone Oral Tablet

"Challenge Agent, Dose and Route of Administration:~Standard release 1x20mg and 1x5mg (25mg total) dose, orally administered."

DRUG

Glucose

75 g in 300 mL solution, orally administered

DRUG

Placebo oral suspension

"Reference Therapy, Dose and Route of Administration:~Placebo suspension, orally administered."

DRUG

CORT118335, 75mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 225mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 675mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 600mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 630mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 375mg

CORT118335 is supplied as capsules for oral dosing

DRUG

CORT118335, 100mg

CORT118335 is supplied as a suspension for oral dosing

DRUG

CORT118335, 300mg

CORT118335 is supplied as a suspension for oral dosing

DRUG

CORT118335, 900mg

CORT118335 is supplied as a suspension for oral dosing

DRUG

CORT118335, 150mg

CORT118335 is supplied as a suspension for oral dosing

DRUG

CORT118335, 1500mg

CORT118335 is supplied as a suspension for oral dosing

DRUG

Placebo oral capsule

Placebo capsules, orally administered

DRUG

CORT118335, dose to be determined

CORT118335 is supplied as suspension for oral dosing

Trial Locations (1)

NG11 6JS

Quotient Clinical, Nottingham