Defunct Company
Total Trials
118
As Lead Sponsor
92
As Collaborator
26
NCT00511979
Comparison of the Effect on the Glucose Infusion Rates Between Inhaled Technosphere Insulin and a Subcutaneous Injection of Regular Human Insulin
Phase: Phase 1
Role: Lead Sponsor
Start: Aug 31, 1999
Completion: Jun 30, 2000
NCT00023647
Vaccine Therapy in Treating Patients With Stage IV Melanoma
Start: Jul 31, 2000
Completion: Nov 30, 2002
NCT00033228
Phase: Phase 1/2
Start: Jan 31, 2002
Completion: Apr 30, 2003
NCT00328614
Samarium-153 With Neoadjuvant Hormonal and Radiation Therapy for Locally Advanced Prostate Cancer
Role: Collaborator
Start: Mar 31, 2003
Completion: Jun 30, 2011
NCT00419302
To Compare the Effect of Inhaled Insulin With Subcutaneously Injected Insulin in Subjects With Type 2 Diabetes Mellitus.
Phase: Phase 2
Start: Oct 31, 2003
Completion: Apr 30, 2004
NCT00511602
Study of the Efficacy and Safety of Inhaled Technosphere Insulin in Patients With Type 2 Diabetes
Start: Dec 31, 2003
Completion: Dec 31, 2005
NCT00511719
Bioavailability of Technosphere® Insulin Versus Subcutaneous Regular Human Insulin in Type 2 Diabetes
Start: Feb 29, 2004
Completion: Mar 31, 2005
NCT00754624
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Start: May 31, 2004
Completion: Oct 31, 2008
NCT00998088
Blood Management in Orthopedic Surgery
Phase: Phase 4
Completion: Sep 30, 2009
NCT00511732
18-Week, Randomized, Double-blind, Placebo Controlled, Forced Titration Study of Patients With Type 2 Diabetes
Start: Jun 30, 2004
Completion: Aug 31, 2007
NCT00934414
Clamp Study Comparing Inhalation of Technosphere®/Insulin in Smokers and Non-Smokers With Type 2 Diabetes
Start: Aug 31, 2004
Completion: Sep 30, 2006
NCT00332488
Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes
Phase: Phase 3
Start: Dec 31, 2004
Completion: Not specified
NCT00559429
Study of Docetaxel +153 Sm-EDTMP in Patients With Hormone-Refractory Prostate Cancer
NCT00539396
A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Receiving Insulin Glargine
Start: Mar 31, 2005
NCT00308737
Safety of Inhaled Insulin With Type 1 and Type 2 Diabetes
Start: Jun 30, 2005
NCT00121095
Study of Samarium Sm-153 Lexidronam Combined With Docetaxel for Patients With Prostate Cancer
Start: Jul 31, 2005
Completion: Jun 30, 2008
NCT00539890
Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Mellitus
Start: Nov 30, 2005
Completion: Jul 31, 2006
NCT00308308
Efficacy & Safety of Inhaled Insulin in Type 1 Diabetes
Start: Feb 28, 2006
Completion: Aug 31, 2008
NCT00309244
Efficacy and Safety in Subjects With Type 2 Diabetes Receiving Subcutaneous Basal Insulin and Prandial Inhalation of Technosphere/Insulin Versus Subcutaneous Premixed Insulin Therapy Over a 52-Week Treatment Period and a 4-Week Follow-up
Completion: Sep 30, 2008
NCT00332826
Inhaled Technosphere Insulin in Subjects With Diabetes Mellitus and Asthma
Start: Jun 30, 2006
Completion: Oct 31, 2007
NCT01021891
A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)
Start: Jul 31, 2006
Completion: Nov 30, 2008
NCT00548119
NeoCart Phase 2 Clinical Trial
Start: Dec 31, 2006
Completion: Mar 31, 2014
NCT00710970
Tamoxifen for Progressive Transitional Cell Carcinoma Following Previous Chemotherapy Treatment
Start: Jan 31, 2007
Completion: Dec 31, 2012
NCT00423254
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.
Start: Feb 28, 2007
Completion: Nov 30, 2009
NCT00441571
Safety Study of a Radiolabeled Antibody (7E11) in Patients With Progressive Hormone Refractory Prostate Cancer
NCT00429507
Sm-EDTMP and Autologous Peripheral Blood Stem Cell Transplantation for Breast Cancer Patients With Bone Only Metastases
Start: Mar 31, 2007
Completion: Nov 30, 2014
NCT00475371
A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult Males
Start: Apr 30, 2007
NCT00741429
A 2-Month Safety Follow-Up Trial
Phase: N/A
Start: May 31, 2007
NCT00626249
Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
Start: Aug 31, 2007
NCT00570687
A Study Comparing Subcutaneous Rapid Acting Insulin and One Formulation of Inhaled Insulin in Subjects With Type 2 Diabetes
Start: Sep 30, 2007
Completion: Jan 31, 2009
NCT00642681
Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal Challenge
Start: Dec 31, 2007
NCT01092910
Esteem Totally Implantable Hearing System
Start: Jan 31, 2008
Completion: Aug 31, 2010
NCT00513669
Phase Ib Trial of Two Virosome Formulated Malaria Vaccine Components (PEV 301, PEV 302) in Tanzania
Completion: Mar 31, 2009
NCT00642538
A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes Mellitus
Start: Feb 29, 2008
NCT01079026
Outcome After Lumbar Epidural Steroid Injection
Start: Mar 31, 2008
Completion: Mar 31, 2010
NCT00662857
A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus and to Compare One of Those Formulations (30Units) With an Injection of Insulin Lispro
Start: Apr 30, 2008
Completion: Dec 31, 2008
NCT00721344
A Study to Determine if Technosphere® Inhalation Powder (FDKP) Causes ECG Changes (QTc) Following the Medication's Inhaled Administration.
NCT00673621
A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
Start: May 31, 2008
NCT00674050
A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy Volunteers
NCT00683436
Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs
NCT00700622
Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Over 16-Weeks
NCT01023360
Evaluation of Antiplatelet Drug Resistance in Taiwanese With VASP & Platelet Mapping ™ Assay
Completion: Oct 31, 2010
NCT00688090
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma.
Start: Jun 30, 2008
Completion: May 31, 2010
NCT00757367
A Trial to Determine How Long Insulin and FDKP (the Molecule That Forms Technosphere Particles) Stays in the Lungs of Healthy Individuals After Inhalation of Technosphere® Insulin (TI) Powder Using Bronchoalveolar Lavage (BAL)
Start: Jul 31, 2008
NCT00744107
Cobra II Study: Use of the Cobra™ Cobalt Super Alloy Coronary Stent System in the Treatment of Coronary Artery Disease
Start: Aug 31, 2008
Completion: Sep 30, 2010
NCT00747006
Safety and Efficacy of Technosphere® Insulin Inhalation Powder (TI Inhalation Powder)When an Optimal Dose is Taken With Varied Carbohydrate Intake
Start: Sep 30, 2008
Completion: May 31, 2011
NCT01798914
Patient Transitioning From Exubera® Inhalation Powder to Technosphere® Insulin Inhalation Powder
Start: Oct 31, 2008
Completion: May 31, 2015
NCT00809302
Efficacy and Safety Study of Aplindore in Patients With Early Parkinson Disease
Start: Dec 31, 2008
Completion: Oct 31, 2009
NCT00834327
Efficacy and Safety Study of Aplindore in Patients With Restless Legs Syndrome
Start: Feb 28, 2009
Completion: Dec 31, 2009
NCT00642616
Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
Start: Mar 31, 2009
NCT01084343
Investigation of the Safety of an HIV-1 Vaccine Given Intra-muscularly and Intra-nasally to Healthy Female Subjects
Start: Nov 30, 2009
NCT01066702
Confirmatory Study of NeoCart in Knee Cartilage Repair
Start: May 31, 2010
Completion: Mar 31, 2019
NCT02666222
The Esteem® Hearing Implant Post Approval Study
Start: Aug 31, 2010
Completion: Mar 31, 2015
NCT02689349
Esteem New Subject Enrollment Post Approval Study
Completion: Sep 30, 2021
NCT01196104
Clinical Trial Evaluating the Efficacy and Safety of Technosphere® Inhalation Insulin (TI) Inhalation Powder Using the Gen2 Inhaler
Start: Sep 30, 2010
Completion: Mar 31, 2012
NCT01536496
Comparison of Rapid Thrombelastography and Conventional Coagulation Testing for Haemostatic Resuscitation in Trauma
Completion: Jul 31, 2014
NCT01026051
Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma
Start: Oct 31, 2010
Completion: Jul 31, 2012
NCT01201928
Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166
NCT01222156
Accuracy and Safety Study of the Magnetecs CGCI System for Intracardiac Mapping
Completion: Dec 31, 2010
NCT01228058
A Prospective Evaluation of Thromboelastography for Identifying Coagulopathy in Severely Injured Patients
Start: Nov 30, 2010
Completion: Jan 31, 2012
NCT01365117
Pharmacokinetic Study in Healthy Volunteers
Start: Jan 31, 2011
Completion: Apr 30, 2011
NCT01357928
Thromboelastography (TEG) Reference Range Study
Start: Apr 30, 2011
Completion: Oct 31, 2011
NCT01359878
Fibrinogen Concentrate as Initial Treatment for Postpartum Haemorrhage: A Randomised Clinically Controlled Trial
Phase: Phase 2/3
Start: May 31, 2011
Completion: Jul 31, 2013
NCT01428102
RapidTEG MA Validation
Start: Jul 31, 2011
Completion: Oct 31, 2012
NCT01445951
Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment Period
Start: Sep 30, 2011
Completion: Jun 30, 2013
NCT01451398
Comparison of Technosphere® Insulin Versus Technosphere Powder (Placebo) in Insulin-Naive Subjects With Type 2 Diabetes Mellitus
Start: Nov 30, 2011
NCT01490762
Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
Start: Dec 31, 2011
NCT01544881
Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
Start: Mar 31, 2012
Completion: Jan 31, 2013
NCT01809054
Pilot Study Evaluating Alterations in Thrombogenicity and Platelet Reactivity Following Lower Extremity Arthroplasty
Start: Apr 30, 2012
Completion: Feb 28, 2013
NCT01779401
Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients
Start: Sep 30, 2012
Completion: Sep 30, 2016
NCT01756976
Clinical Evaluation of the OrthoPAT Advance System
Start: Dec 31, 2012
Completion: Aug 31, 2013
NCT01818167
An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.
Start: Jan 5, 2013
Completion: Jan 21, 2015
NCT01764061
Clinical Investigational Protocol for 2 RBC Single Unit Recovery on MCS®+ 8150 Using LN832 Disposable Sets (US)
Start: Jan 31, 2013
Completion: Sep 30, 2013
NCT01459133
Single Site, Single Subject, Treatment IND With Mannkind Corporation's Technosphere Inhalation System
Start: May 31, 2013
Completion: Oct 31, 2014
NCT01882972
Strength for Health
Start: Jun 30, 2013
NCT01902121
Compare the Same Dosage of Insulin Using a Combination of Cartridges, 30 Units as 2 Cartridges vs. 1 Cartridge
Start: Aug 31, 2013
Completion: Aug 31, 2014
NCT01982604
Comparison of 30 Units of TI (Technosphere® Insulin) Prepared With Insulin From Two Different Suppliers
Start: Nov 30, 2013
NCT04023682
ProvodineTM Decreases Hand Contamination
Start: Dec 31, 2013
NCT02949570
Study to Assess Efficacy and Safety of Inecalcitol in Imatinib-Treated Residual Chronic Myeloid Leukaemia: INIM Study
Start: Feb 28, 2014
Completion: Apr 30, 2018
NCT02095769
Pharmacogenomic Testing Of the Elderly To Reduce Morbidity
Start: Apr 30, 2014
Completion: Jan 31, 2017
NCT02145507
Evaluation of Whole Blood With CPD Anticoagulant and AS-7/SOLX Additive Solution
Completion: Jan 31, 2015
NCT02110576
Procedure For The Reference Range Study For Absolute MA
Start: May 31, 2014
NCT02262247
A Post-Market Clinical Trial for Access and Visualization of the Oropharynx, Hypopharynx and Larynx During Transoral Procedures
Start: Jul 31, 2014
Completion: Dec 31, 2015
NCT02209662
Safety and Efficacy Study of APIC-PRP in Non-healing Diabetic Foot Ulcers
Start: Oct 31, 2014
NCT02210468
APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee
Start: May 31, 2015
Completion: Dec 31, 2016
NCT02397811
Astaxanthin Formulation Bioavailability
Start: Jun 30, 2015
NCT02470637
Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afrezza and 3 Dose Levels of Insulin Lispro in Patients With Type 1 Diabetes Mellitus
Completion: Sep 30, 2015
NCT02476851
Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly With Vacuum Tube Holder
NCT02485327
PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Diabetes Mellitus Type 1 (T1DM)
Start: Jul 31, 2015
Completion: Nov 30, 2015
NCT03972826
Use of Provodine to Protect HCW Hands (Aim II.1)
Start: Jan 1, 2016
Completion: Nov 9, 2021
NCT02802267
Efficacy Study of Inecalcitol With Decitabine in Acute Myeloid Leukemia Patients Unfit for Standard Chemotherapy
Start: Jun 30, 2016
Completion: Dec 31, 2019
NCT02798328
Direct Oral Anticoagulant Assay Detection & Classification Study for the TEG 6S System
Start: Aug 31, 2016
Completion: Sep 30, 2017
NCT02527265
Afrezza Safety and Pharmacokinetics Study in Pediatric Patients
Start: Sep 28, 2017
Completion: Jun 25, 2020
NCT03143816
Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT Study
Start: Sep 30, 2017
Completion: Jan 31, 2018
NCT03313960
"A Randomized Controlled Trial Evaluating One Drop
Phase: Premium With Afrezza vs. One Drop
Start: Oct 5, 2017
Completion: Dec 30, 2019
NCT03323060
Post-Market Clinical Follow-Up to Access & Visualize the Anus, Rectum, & Distal Colon During Transanal Procedures
Start: Oct 11, 2017
NCT03324776
Initiating Mealtime Ultra-Rapid Acting Insulin (Afrezza) in Uncontrolled Type 2 Diabetes Patients
Start: Oct 16, 2017
Completion: Jun 10, 2020
NCT03464864
Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers
Start: Mar 9, 2018
Completion: Jun 5, 2018
NCT04125082
A Study to Evaluate Time in Range in Type 2 Diabetics Using Afrezza® Plus Basal Insulin Compared to Multiple Daily Injections
Start: Feb 27, 2019
Completion: Mar 15, 2020
NCT03916731
Evaluation of STARgraft AV for Hemodialysis Access
Start: Apr 2, 2019
Completion: May 11, 2021
NCT04320823
IMPACT (Improving Plasma Collection) Clinical Trial
Start: Jan 6, 2020
Completion: Apr 27, 2020
NCT04493307
The Evaluation of Hemostasis in Hospitalized COVID-19 Patients
Start: Jun 30, 2020
Completion: Jun 30, 2021
NCT04783779
Evaluation of STARgraft-2 for Hemodialysis Access
Start: Feb 16, 2021
Completion: Oct 31, 2023
NCT04849845
Afrezza® Dosing Optimization Study
Start: Apr 9, 2021
Completion: May 28, 2021
NCT06261580
Normal Reference Range Study With the TEG6s Heparin Neutralization Cartridge in Healthy Volunteers
Start: Jul 28, 2021
Completion: Oct 25, 2021
NCT04974528
Afrezza® INHALE-1 Study in Pediatrics
Start: Sep 29, 2021
Completion: Apr 29, 2025
NCT06352125
An Observational Trial to Assess the Performance of the TEG® 6s Diagnostic System With the Citrated K, KH, RTH, FFH Cartridge
Start: Dec 9, 2021
Completion: Jan 31, 2023
NCT05243628
Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 Diabetes
Start: Mar 31, 2022
Completion: Oct 17, 2022
NCT05517811
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
Start: Jun 26, 2022
Completion: Jul 31, 2028
NCT05729620
Evaluation of STARgraft-3 for Hemodialysis
Start: Nov 29, 2022
Completion: Jul 31, 2024
NCT05904743
INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes
Start: Jul 7, 2023
Completion: Jun 24, 2024
NCT05904691
Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration
Start: Nov 1, 2023
Completion: Nov 30, 2026
NCT06532942
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MKND-201 in Healthy Volunteers
Start: May 28, 2024
Completion: Oct 31, 2024
NCT06263270
Evaluation of CYT-108, a Recombinant Protease Inhibitor, for Treatment of Mild to Moderate Primary Osteoarthritis of the Knee
Start: Jun 1, 2024
Completion: Dec 31, 2024
NCT06418711
ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension
Start: Sep 11, 2024
Completion: Dec 1, 2028
NCT06699797
Pivotal Clinical Trial Evaluating the Safety and Efficacy of the Fully Implanted Acclaim Cochlear Implant
Start: Feb 6, 2025
Completion: Jan 31, 2028
NCT06535789
Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational Diabetes
Start: May 31, 2025
Completion: Jul 31, 2025
NCT06880835
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin Delivery
Start: Jun 5, 2025
Completion: May 31, 2026