Gene Therapy, Cellular Extraction & Reintroduction
Total Trials
19
As Lead Sponsor
14
As Collaborator
5
Total Enrollment
1,968
NCT02151526
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease
Phase: Phase 1/2
Role: Lead Sponsor
Start: Jun 7, 2013
Completion: Feb 26, 2019
NCT01896102
A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
Phase: Phase 2/3
Start: Aug 21, 2013
Completion: Mar 26, 2021
NCT01745120
A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants
Start: Aug 31, 2013
Completion: Feb 21, 2018
NCT02633943
Long-term Follow-up of Subjects With Transfusion-Dependent β-Thalassemia (TDT) Treated With Ex Vivo Gene Therapy
Phase: N/A
Start: Jan 31, 2014
Completion: Nov 30, 2035
NCT02140554
A Study Evaluating the Safety and Efficacy of Lovo-cel in Severe Sickle Cell Disease
Start: Feb 2, 2015
Completion: Jan 30, 2024
NCT02204904
Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD)
Start: Apr 30, 2015
Completion: Dec 6, 2019
NCT02658929
Study of bb2121 in Multiple Myeloma
Phase: Phase 1
Role: Collaborator
Start: Dec 22, 2015
Completion: Sep 22, 2022
NCT02698579
Long-term Follow-up of Participants With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product
Start: Jan 22, 2016
Completion: Aug 31, 2038
NCT02906202
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Participants With Transfusion-Dependent β-Thalassemia, Who do Not Have a β0/β0 Genotype
Phase: Phase 3
Start: Aug 8, 2016
Completion: Mar 31, 2022
NCT03207009
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Participants With Transfusion-Dependent β-Thalassemia
Start: Jun 8, 2017
Completion: Nov 15, 2022
NCT03852498
A Clinical Study to Assess the Efficacy and Safety of Gene Therapy for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
Start: Jan 24, 2019
Completion: Jul 24, 2023
NCT03131934
Immunotherapy With Tacrolimus Resistant EBV CTL for Lymphoproliferative Disease After Solid Organ Transplant
Phase: Early Phase 1
Start: May 31, 2019
Completion: May 15, 2025
NCT04293185
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease
Start: Feb 14, 2020
Completion: Nov 30, 2027
NCT04413539
Evaluation of Impact of Disease on Quality of Life, Education and Socio-professional Integration of Adults and Parents of Children Living with Sickle- Cell Disease in France
Start: Jun 2, 2020
Completion: Apr 27, 2021
NCT04628585
Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy
Start: Oct 21, 2020
Completion: Jan 31, 2038
NCT05445128
Study of MGTA-145 and Plerixafor in Patients With Sickle Cell Disease
Phase: Phase 2
Start: Jun 24, 2022
Completion: Feb 2, 2023
NCT05353647
A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
Start: Jul 12, 2022
Completion: Jul 31, 2027
NCT06271512
A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel
Start: Jan 23, 2024
Completion: Dec 31, 2043
NCT06224413
A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel
Start: Mar 27, 2024
Completion: Dec 30, 2047
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