Cardiovascular treatments
Total Trials
16
As Lead Sponsor
11
As Collaborator
5
Total Enrollment
1,660
NCT01092325
Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure
Phase: Phase 1/2
Role: Collaborator
Start: Jun 30, 2009
Completion: May 31, 2010
NCT01096043
A Dose-Defining Study of CXL-1020 in Patients With Systolic Heart Failure
Phase: Phase 2
Start: Apr 30, 2010
Completion: Feb 29, 2012
NCT02819271
A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers
Phase: Phase 1
Start: Feb 28, 2014
Completion: Apr 30, 2014
NCT02157506
A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure
Start: Jun 30, 2014
Completion: Jul 31, 2015
NCT02350114
An Observational Study of the Functional Capacity of Heart Failure
Phase: N/A
Start: Nov 30, 2014
NCT02998450
A Study of IMR-687 in Healthy Adult Volunteers
Role: Lead Sponsor
Start: Oct 18, 2016
Completion: Jul 8, 2017
NCT03401112
A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia)
Start: Jan 26, 2018
Completion: Aug 28, 2020
NCT04474314
A Study of IMR-687 in Subjects With Sickle Cell Disease
Start: Aug 13, 2020
Completion: May 4, 2022
NCT04411082
A Study of IMR-687 in Subjects With Beta Thalassemia
Start: Oct 16, 2020
NCT05312021
Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction
Start: Apr 30, 2022
Completion: Nov 30, 2023
NCT05409183
Effectiveness of CRD-740 in Heart Failure
Start: May 26, 2022
Completion: Jul 25, 2023
NCT05437094
Effect of Coadministration of Itraconazole on the Pharmacokinetics of CRD-740
Start: Jun 27, 2022
Completion: Aug 10, 2022
NCT06005428
Effectiveness of CRD-4730 in Participants With Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Start: Nov 7, 2023
Completion: May 31, 2025
NCT06215586
Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Preserved Ejection Fraction (Cycle-2-PEF)
Start: Feb 13, 2024
Completion: Sep 2, 2025
NCT06215911
A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)
Completion: Oct 31, 2025
NCT06658899
A Phase 2 Study of CRD-4730 in CPVT
Start: Dec 31, 2025
Completion: Apr 30, 2027
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