A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

557

Participants

Timeline

Start Date

February 13, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
Heart FailureHeart Failure With Reduced Ejection FractionCardiovascular DiseasesHeart Diseases
Interventions
DRUG

Tovinontrine (CRD-750)

Tablets administered orally

DRUG

Placebo

Tablets administered orally

Trial Locations (139)

243

Cardurion Investigative Site, New Taipei City

1000

Cardurion Investigative Site, Sofia

1070

Cardurion Investigative Site, Brussels

1148

Cardurion Investigative Site, Budapest

1233

Cardurion Investigative Site 2, Sofia

Cardurion Investigative Site, Sofia

3000

Cardurion Investigative Site, Hatvan

3200

Cardurion Investigative Site, Gyöngyös

3500

Cardurion Investigative Site, Hasselt

4002

Cardurion Investigative Site, Plovdiv

4003

Cardurion Investigative Site, Plovdiv

4032

Cardurion Investigative Site, Chermside

4222

Cardurion Investigative Site, Southport

4400

Cardurion Investigative Site, Pazardzhik

5006

Cardurion Investigative Site, Veliko Tarnovo

5300

Cardurion Investigative Site, Gabrovo

5900

Cardurion Investigative Site, Orosháza

6000

Cardurion Investigative Site, Stara Zagora

7000

Cardurion Investigative Site, Rousse

7400

Cardurion Investigative Site, Kaposvár

8000

Cardurion Investigational Site, Bruges

8008

Cardurion Investigative Site, Burgas

8230

Cardurion Investigative Site, Balatonfüred

8500

Cardurion Investigative Site, Kortrijk

8900

Cardurion Investigative Site, Zalaegerszeg

9000

Cardurion Investigative Site, Ghent

9100

Cardurion Investigative Site, Sint-Niklaas

10025

Cardurion Investigative Site, New York

10507

Cardurion Investigative Site, Taipei

10787

Cardurion Investigative Site, Berlin

14004

Cardurion Investigative Site, Córdoba

14215

Cardurion Investigative Site, Buffalo

15706

Cardurion Investigative Site, Santiago de Compostela

20138

Cardurion Investigative Site, Milan

21201

Cardurion Investigative Site, Baltimore

26871

Cardurion Investigative Site, Papenburg

28041

Cardurion Investigative Site, Madrid

29010

Cardurion Investigative Site, Málaga

30120

Cardurion Investigative Site, El Palmar

32216

Cardurion Investigative Site, Jacksonville

33137

Cardurion Investigative Site, Miami

35233

Cardurion Investigative Site, Birmingham

37232

Cardurion Investigative Site, Nashville

39120

Cardurion Investigative Site, Magdeburg

41009

Cardurion Investigative Site, Seville

44195

Cardurion Investigative Site, Cleveland

46026

Cardurion Investigative Site, Valencia

53792

Cardurion Investigative Site, Madison

57701

Cardurion Investigative Site, Rapid City

60429

Cardurion Investigative Site, Hazel Crest

61636

Cardurion Investigative Site, Peoria

63110

Cardurion Investigative Site, St Louis

68198

Cardurion Investigative Site, Omaha

70433

Cardurion Investigative Site, Covington

71301

Cardurion Investigative Site, Alexandria

72204

Cardurion Investigative Site, Little Rock

73135

Cardurion Investigative Site, Oklahoma City

75069

Cardurion Investigative Site, McKinney

75226

Cardurion Investigative Site, Dallas

80756

Cardurion Investigative Site, Kaohsiung City

90211

Cardurion Investigative Site, Beverly Hills

90502

Cardurion Investigative Site, Torrance

91405

Cardurion Investigative Site, Van Nuys

92868

Cardurion Investigative Site, Orange

98195

Cardurion Investigative Site, Seattle

100225

Cardurion Investigative Site, Taipei

407219

Cardurion Investigative Site, Taichung

05401

Cardurion Investigative Site, Burlington

Unknown

Cardurion Investigative Site, Perth

Cardurion Investigative Site, Brussels

Cardurion Investigative Site, Genk

Cardurion Investigative Site, Montreal

Cardurion Investigative Site, Bergamo

Cardurion Investigative Site, Napoli

Cardurion Investigative Site, Rozzano

Cardurion Investigative Site, Riga

Cardurion Investigative Site, Kaunas

Cardurion Investigative Site, Klaipėda

Cardurion Investigative Site, Panevezys

Cardurion Investigative Site, Christchurch

Cardurion Investigative Site, Dunedin

Cardurion Investigative Site, Lodz

Cardurion Investigative Site, Szczecin

Cardurion Investigative Site, Bardejov

Cardurion Investigative Site, Bratislava

Cardurion Investigative Site, Košice

Cardurion Investigative Site, Žilina

N1R 6V6

Cardurion Investigative Site, Cambridge

L8L 2X2

Cardurion Investigative Site, Hamilton

G7H 7K9

Cardurion Investigative Site, Chicoutimi

J1G 2E8

Cardurion Investigative Site, Sherbrooke

G9B 2N3

Cardurion Investigative Site, Trois-Rivières

500 02

Cardurion Investigative Site, Hradec Králové

500 05

Cardurion Investigative Site, Hradec Králové

128 08

Cardurion Investigative Site, Prague

0102

Cardurion Investigative Site, Tbilisi

0131

Cardurion Investigative Site, Tbilisi

0141

Cardurion Investigative Site, Tbilisi

0159

Cardurion Investigative Site 2, Tbilisi

Cardurion Investigative Site, Tbilisi

0160

Cardurion Investigative Site, Tbilisi

0186

Cardurion Investigative Site, Tbilisi

04910

Cardurion Investigative Site, Elsterwerda

01067

Cardurion Investigative Site, Dresden

H-1122

Cardurion Investigative Site, Budapest

4462 RA

Cardurion Investigative Site, Goes

9713 GZ

Cardurion Investigative Site, Groningen

7772 SE

Cardurion Investigative Site, Hardenberg

8601 ZR

Cardurion Investigative Site, Sneek

2545 AA

Cardurion Investigative Site, The Hague

3582 KE

Cardurion Investigative Site, Utrecht

5504 DB

Cardurion Investigative Site, Veldhoven

7207 AE

Cardurion Investigative Site, Zutphen

05-825

Cardurion Investigative Site, Grodzisk Mazowiecki

31-216

Cardurion Investigative Site, Krakow

92-213

Cardurion Investigative Site, Lodz

94-255

Cardurion Investigative Site, Lodz

20-011

Cardurion Investigative Site, Lublin

20-049

Cardurion Investigative Site, Lublin

81-717

Cardurion Investigative Site, Sopot

87-100

Cardurion Investigative Site, Torun

04-628

Cardurion Investigative Site, Warsaw

50-556

Cardurion Investigative Site, Wroclaw

50-981

Cardurion Investigative Site, Wroclaw

972 51

Cardurion Investigative Site, Handlová

040 022

Cardurion Investigative Site, Košice

949 01

Cardurion Investigative Site, Nitra

080 01

Cardurion Investigative Site, Prešov

03010

Cardurion Investigative Site, Alicante

M23 9QZ

Cardurion Investigative Site, Wythenshawe

CF31 1RQ

Cardurion Investigative Site, Bridgend

PO19 6SE

Cardurion Investigative Site, Chichester

DD1 9SY

Cardurion Investigative Site, Dundee

G81 4DY

Cardurion Investigative Site, Glasgow

HA1 3UJ

Cardurion Investigative Site, Harrow

TW7 6AF

Cardurion Investigative Site, Isleworth

NW1 2BU

Cardurion Investigative Site, London

SE5 9RS

Cardurion Investigative Site, London

SO16 6YD

Cardurion Investigative Site, Southampton

All Listed Sponsors
lead

Cardurion Pharmaceuticals, Inc.

INDUSTRY