Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

June 30, 2009

Primary Completion Date

May 31, 2010

Study Completion Date

May 31, 2010

Conditions
Heart Failure
Interventions
DRUG

CXL-1020

Intravenous infusion of one of 3 active dosages of CXL-1020

DRUG

CXL-1020

Intravenous infusion of one of 3 active dosages of CXL-1020 at dosages higher than in Cohort 1

DRUG

Placebo for CXL-1020 Cohort 1

A 4 hour infusion of a IV solution containing 5% Dextrose in water (Sugar Water)

DRUG

Placebo for CXL-1020 Cohort 2

A 4 hour infusion of a IV solution containing 5% Dextrose in water (Sugar Water)

DRUG

CXL-1020 Dose for Echo Cohort A

A 4 hour fixed dose of CXL-1020 which was studied in Cohort 1 or 2 which was demonstrated to be safe and well tolerated and have some anticipated hemodynamic effect

DRUG

CXL-1020 Doses for Echo Cohort B

A 2 hour dose level of CXL-1020 which was studied in Cohort 1 or 2 which was demonstrated to be safe and well tolerated and have some anticipated hemodynamic effect followed by another higher 2 hour dose level of CXL-1020 which was studied in Cohort 1 or 2 which was demonstrated to be safe and well tolerated and have some anticipated hemodynamic effect

Trial Locations (1)

92780

Orange County Clinical Research Center, Tustin

Sponsors
All Listed Sponsors
collaborator

Cardioxyl Pharmaceuticals, Inc

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT01092325 - Safety and Hemodynamic Effects and Pharmacokinetics of CXL-1020 in Patients With Stable Heart Failure | Biotech Hunter | Biotech Hunter