Immuno-oncology
Total Trials
12
As Lead Sponsor
9
As Collaborator
3
Total Enrollment
1,158
NCT03013218
A Study of Evorpacept (ALX148) in Patients With Advanced Solid Tumors and Lymphoma (ASPEN-01)
Phase: Phase 1
Role: Lead Sponsor
Start: Feb 3, 2017
Completion: Jul 8, 2025
NCT04417517
A Study of Evorpacept (ALX148) With Azacitidine for Higher Risk Myelodysplastic Syndrome (ASPEN-02)
Start: Oct 2, 2020
Completion: Jun 10, 2025
NCT04675294
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
Phase: Phase 2
Start: Apr 2, 2021
Completion: Jun 30, 2026
NCT04755244
A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)
Start: May 5, 2021
Completion: Aug 16, 2023
NCT04675333
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
Start: May 10, 2021
NCT05027139
A Study of Zanidatamab (ZW25) With Evorpacept (ALX148) in Patients With Advanced HER2-expressing Cancer
Phase: Phase 1/2
Role: Collaborator
Start: Sep 15, 2021
Completion: Sep 30, 2025
NCT05002127
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
Phase: Phase 2/3
Start: Jan 15, 2022
NCT05167409
A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer
Start: Jul 28, 2022
Completion: Mar 1, 2026
NCT05524545
A Study of Evorpacept (ALX148) With Enfortumab Vedotin for Subjects With Urothelial Carcinoma (ASPEN-07)
Start: Nov 2, 2022
Completion: Jun 27, 2025
NCT05467670
Safety and Efficacy of Anti-CD47, ALX148 in Combination with Liposomal Doxorubicin and Pembrolizumab in Recurrent Platinum-resistant Ovarian Cancer
Start: Mar 30, 2023
Completion: Dec 31, 2031
NCT07007559
ASPEN-09: A Study of Evorpacept in Combination With Anti-cancer Therapies in Advanced / Metastatic Malignancies
Start: Apr 28, 2025
Completion: Dec 31, 2027
NCT07085091
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
Start: Aug 18, 2025
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