A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

January 15, 2022

Primary Completion Date

May 24, 2024

Study Completion Date

June 30, 2026

Conditions
Gastric CancerGastroesophageal Junction AdenocarcinomaGastric Adenocarcinoma
Interventions
DRUG

Evorpacept (ALX148)

IV Q2W

DRUG

Trastuzumab

IV Q2W

DRUG

Ramucirumab

IV Q2W

DRUG

Paclitaxel

IV Days 1, 8, and 15 of a 28-day cycle

Trial Locations (83)

112

Koo Foundation Sun Yat-Sen Cancer Center, Beitou

Taipei Veterans General Hospital, Taipei

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

2650

Universitair Ziekenhuis Antwerpen, Antwerp

3000

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven

3168

Monash Medical Centre, Clayton

4000

Centre Hospitalier Universitaire de Liège, Liège

4215

Icon Cancer Centre Southport, Southport

10048

National Taiwan University Hospital, Taipei

10408

National Cancer Center - Korea, Goyang-si

Korea University Guro Hospital, Seoul

12800

Vseobecna Fakultni Nemocnice v Praze, Prague

13009

Institut Paoli-Calmettes, Marseille

13620

Seoul National University Bundang Hospital, Seongnam

14004

Hospital Universitario Reina Sofía, Córdoba

14068

Hallym University Sacred Heart Hospital, Dongan

16247

The Catholic University of Korea Saint Vincent's Hospital, Suwon

20133

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan

22031

NEXT Virginia, Fairfax

25030

Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz, Besançon

27003

Hospital Universitario Lucus Augusti, Lugo

28034

Hospital Universitario Ramón y Cajal, Madrid

29200

Hôpital Morvan, Brest

31059

Hôpital Rangueil, Toulouse

33000

Centre Hospitalier Universitaire de Bordeaux, Bordeaux

33100

Azienda Sanitaria Universitaria Friuli Centrale - P.O. Santa Maria della Misericordia, Udine

35015

Chungnam National University Hospital, Daejeon

37232

Vanderbilt University Medical Center, Nashville

39008

Hospital Universitario Marqués de Valdecilla, Santander

40447

China Medical University Hospital, Taichung

42415

Yeungnam University Medical Center, Daegu

48108

Inje University Haeundae Paik Hospital, Busan

49201

Dong-A University Hospital, Busan

49241

Pusan National University Hospital, Busan

50009

Hospital Universitario Miguel Servet, Zaragoza

50134

Azienda Ospedaliero - Universitaria Careggi, Florence

69008

Centre Léon Bérard, Lyon

Hôpital Privé Jean Mermoz, Lyon

73657

Chi Mei Hospital - Liouying, Tainan City

75012

Hôpital Saint-Antoine, Paris

Hôpital Trousseau, Paris

90095

University of California Los Angeles, Los Angeles

92801

The Oncology Institute of Hope & Innovation, Anaheim

95123

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi, Catania

98109

Fred Hutchinson Cancer Center, Seattle

168583

National Cancer Centre Singapore, Singapore

217562

Icon Cancer Centre Farrer Park, Singapore

500 05

Fakultní Nemocnice Hradec Králové, Hradec Králové

779 00

Fakultní Nemocnice Olomouc, Olomouc

00128

Policlinico Universitario Campus Bio-Medico, Roma

277-8577

National Cancer Center Hospital East, Chiba

811-1395

Kyushu Cancer Center, Fukuoka

501-1194

Gifu University Hospital, Gifu

861-8520

Japanese Red Cross Kumamoto Hospital, Kumamoto

602-8566

University Hospital Kyoto Prefectural University of Medicine, Kyoto

852-8501

Nagasaki University Hospital, Nagasaki

541-8567

Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka

589-8511

Kindai University Hospital, Osaka

879-5593

Oita University Hospital - Hasama Campus, Ōita

362-0806

Saitama Cancer Center, Saitama

980-8574

Tohoku University Hospital, Sendai

411-8777

Shizuoka Cancer Center, Shizuoka

104-0045

National Cancer Center Hospital, Tokyo

135-8550

Cancer Institute Hospital of JFCR, Tokyo

241-8515

Kanagawa Cancer Center, Yokohama

561-712

Jeonbuk National University Hospital, Jeonju

02708

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03181

Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul

05505

Asan Medical Center, Seoul

06273

Gangnam Severance Hospital, Seoul

Severance Hospital, Seoul

06351

Samsung Medical Center, Seoul

07061

Boramae Medical Center, Seoul

03203

Hospital General Universitario de Elche, Alicante

08916

Hospital Germans Trias i Pujol, Badalona

08035

Hospital Quirónsalud Barcelona, Barcelona

Hospital Universitari Vall d'Hebrón, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

NW3 2QG

Royal Free Hospital, London

SE1 9RT

Guy's and Saint Thomas' NHS Foundation Trust, London

SW3 6JJ

The Royal Marsden Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

ALX Oncology Inc.

INDUSTRY