Clinical Trials for Exelixis

Explore 71 clinical trials worldwide

Showing 1-50 of 71 trials

Active filters:Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruitingSponsor: Exelixis

Clinical Trials (71)

NCT07218666
Zanzalintinib in Men With Aggressive Variant Prostate Cancer
PHASE2Not yet recruiting
30 participants
Started: May 31, 2026 · Completed: Dec 31, 2027
1 condition3 sponsors0 locations
NCT07193550
A Phase 2 Trial of Zanzalintinib in Advanced/Metastatic Bone Sarcomas (ZAMBONE)
PHASE2Not yet recruiting
70 participants
Started: May 31, 2026 · Completed: Oct 31, 2031
1 condition2 sponsors1 location
NCT07187869
Modulation of the Bone Immune Microenvironment Following Cabozantinib Treatment of Bone Metastatic Clear Cell Renal Cell Carcinoma: Proof of Concept Study
PHASE1Not yet recruiting
16 participants
Started: Mar 31, 2026 · Completed: Apr 7, 2029
1 condition2 sponsors0 locations
NCT06863311
Trial of XL092 in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC
PHASE2Recruiting
70 participants
Started: Dec 31, 2025 · Completed: Dec 31, 2028
3 conditions3 sponsors1 location
NCT06794229
Neoadjuvant Zanzalintinib Plus Nivolumab in Patients With Locally Advanced and/or Inoperable Clear Cell Renal Cell Carcinoma With or Without Non-measurable Metastasis
PHASE2Not yet recruiting
69 participants
Started: Nov 30, 2025 · Completed: Jun 30, 2029
1 condition3 sponsors0 locations
NCT07185945
Zanzalintinib for Advanced Urothelial Carcinoma Progressing After Prior Therapy
PHASE2Not yet recruiting
44 participants
Started: Nov 30, 2025 · Completed: Mar 31, 2029
1 condition3 sponsors0 locations
NCT06926634
Zanzalintinib Maintenance in Patients With High Grade Neuroendocrine Neoplasms (HG-NENs)
PHASE2Not yet recruiting
32 participants
Started: Oct 31, 2025 · Completed: Oct 31, 2034
1 condition2 sponsors2 locations
NCT06795009
Zanzalintinib in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer
PHASE1Recruiting
36 participants
Started: Oct 31, 2025 · Completed: Apr 30, 2035
2 conditions3 sponsors4 locations
NCT06957431
Zanzalintinib Combined With Eribulin in Advanced Liposarcoma and Leiomyosarcoma
PHASE1Not yet recruiting
18 participants
Started: Sep 30, 2025 · Completed: Sep 30, 2033
3 conditions2 sponsors1 location
NCT06968988
Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma
PHASE1Not yet recruiting
18 participants
Started: Sep 30, 2025 · Completed: Mar 31, 2031
1 condition2 sponsors1 location
NCT07043608
Zanzalintinib for Metastatic Clear Cell Renal Cell Carcinoma With Bone Metastases
PHASE2Not yet recruiting
20 participants
Started: Sep 30, 2025 · Completed: Sep 30, 2029
10 conditions2 sponsors1 location
NCT06937866
Maintenance Zanzalintinib With Etoposide After HDCT in GCT
PHASE1/PHASE2Not yet recruiting
38 participants
Started: Sep 30, 2025 · Completed: Mar 31, 2032
1 condition2 sponsors1 location
NCT06912087
Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC
PHASE1Active, not recruiting
36 participants
Started: Sep 29, 2025 · Completed: Jun 5, 2027
6 conditions2 sponsors1 location
NCT07123103
A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors
PHASE1Recruiting
150 participants
Started: Aug 18, 2025 · Completed: Feb 29, 2028
1 condition1 sponsor2 locations
NCT06959511
Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery
PHASE2Recruiting
45 participants
Started: Jul 22, 2025 · Completed: Oct 1, 2029
2 conditions2 sponsors1 location
NCT06943755
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
PHASE2/PHASE3Recruiting
440 participants
Started: Jul 21, 2025 · Completed: Jun 30, 2029
2 conditions1 sponsor9 locations
NCT07049926
Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)
PHASE1/PHASE2Recruiting
100 participants
Started: Jul 20, 2025 · Completed: Oct 26, 2031
1 condition2 sponsors6 locations
NCT06902376
XL092 and Cemiplimab in BRAF WT Thyroid Cancer
PHASE1Recruiting
12 participants
Started: Jun 3, 2025 · Completed: Aug 31, 2028
3 conditions3 sponsors2 locations
NCT06962332
Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)
PHASE1Recruiting
20 participants
Started: May 13, 2025 · Completed: Apr 30, 2026
2 conditions1 sponsor2 locations
NCT06952010
A Study of XB628 in Participants With Recurrent Advanced or Metastatic Solid Tumors
PHASE1Recruiting
75 participants
Started: May 1, 2025 · Completed: Nov 30, 2027
4 conditions1 sponsor4 locations
NCT06835972
A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)
PHASE1/PHASE2Recruiting
43 participants
Started: Feb 14, 2025 · Completed: Feb 28, 2027
2 conditions3 sponsors8 locations
NCT05859217
A Study of Combining Cabozantinib and Atezolizumab for Advanced/Metastatic NSCLC (Cabatezo-1)
PHASE2Not yet recruiting
40 participants
Started: Dec 31, 2024 · Completed: Jun 30, 2028
4 conditions3 sponsors4 locations
NCT06698250
Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)
PHASE2Recruiting
40 participants
Started: Dec 9, 2024 · Completed: Apr 30, 2027
1 condition2 sponsors1 location
NCT06568562
XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer
PHASE2Recruiting
32 participants
Started: Dec 9, 2024 · Completed: Dec 31, 2028
1 condition2 sponsors1 location
NCT06545331
Study of XB010 in Subjects With Solid Tumors
PHASE1Recruiting
396 participants
Started: Aug 6, 2024 · Completed: Oct 20, 2027
6 conditions1 sponsor9 locations
NCT06082167
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
PHASE2/PHASE3Active, not recruiting
600 participants
Started: Jun 7, 2024 · Completed: Mar 31, 2029
1 condition2 sponsors168 locations
NCT05932862
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
PHASE1Recruiting
429 participants
Started: Apr 3, 2024 · Completed: Aug 3, 2029
1 condition1 sponsor16 locations
NCT05931393
Sequential Treatment of Cabozantinib for Advanced Renal Cell Carcinoma (RCC)
PHASE2Recruiting
18 participants
Started: Dec 20, 2023 · Completed: Dec 31, 2028
2 conditions2 sponsors1 location
NCT06132945
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
PHASE1Active, not recruiting
2 participants
Started: Nov 10, 2023 · Completed: Nov 30, 2027
2 conditions2 sponsors7 locations
NCT06156410
Cabozantinib With Ifosfamide in Ewing's Sarcoma and Osteosarcoma
PHASE1Recruiting
30 participants
Started: Oct 24, 2023 · Completed: Nov 30, 2028
2 conditions4 sponsors4 locations
NCT05613894
Dose-Escalation Study of Cabozantinib in Combination With Lutetium-177 (177Lu)-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer
PHASE1Recruiting
33 participants
Started: Jul 14, 2023 · Completed: May 1, 2028
1 condition2 sponsors1 location
NCT05502315
Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer
PHASE2Recruiting
47 participants
Started: Feb 2, 2023 · Completed: Apr 12, 2027
2 conditions3 sponsors4 locations
NCT05678673
Study of XL092 + Nivolumab vs Sunitinib in Subjects With Advanced or Metastatic Non-Clear Cell Renal Cell Carcinoma
PHASE3Active, not recruiting
317 participants
Started: Jan 1, 2023 · Completed: Jun 30, 2028
1 condition1 sponsor163 locations
NCT05249114
Study of Cabozantinib With Lu-177 in Patients With Somatostatin Receptor 2 Positive Neuroendocrine Tumors
PHASE1Active, not recruiting
6 participants
Started: Dec 28, 2022 · Completed: Dec 31, 2026
1 condition3 sponsors1 location
NCT05048212
A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases
PHASE2Recruiting
20 participants
Started: Sep 20, 2022 · Completed: Dec 31, 2025
2 conditions3 sponsors1 location
NCT05425940
Study of XL092 + Atezolizumab vs Regorafenib in Participants With Metastatic Colorectal Cancer
PHASE3Active, not recruiting
901 participants
Started: Sep 7, 2022 · Completed: Jan 31, 2027
1 condition1 sponsor133 locations
NCT05135975
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
PHASE2Recruiting
86 participants
Started: Jul 20, 2022 · Completed: Dec 31, 2029
2 conditions2 sponsors6 locations
NCT05425004
Cabozantinib for Patients With Recurrent or Progressive Meningioma
PHASE2Recruiting
24 participants
Started: Jun 1, 2022 · Completed: May 31, 2028
1 condition2 sponsors3 locations
NCT04919122
Outcomes Database to prospectivelY aSSEss the Changing TherapY Landscape in Renal Cell Carcinoma
N/AActive, not recruiting
468 participants
Started: Apr 1, 2022 · Completed: Jul 31, 2026
1 condition6 sponsors14 locations
NCT05263050
Trial of an Alternative Cabozantinib Dosing Schedule in Metastatic Renal Cell Carcinoma and Neuroendocrine Tumors
PHASE2Recruiting
111 participants
Started: Jan 21, 2022 · Completed: Feb 28, 2027
4 conditions2 sponsors1 location
NCT05176483
Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors
PHASE1Active, not recruiting
1,274 participants
Started: Dec 14, 2021 · Completed: Jun 28, 2030
8 conditions1 sponsor122 locations
NCT04878029
Cabozantinib in Combination with Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Cancer
PHASE1Recruiting
32 participants
Started: Jul 23, 2021 · Completed: Dec 21, 2026
4 conditions3 sponsors1 location
NCT04963283
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
PHASE2Active, not recruiting
48 participants
Started: Jun 23, 2021 · Completed: Feb 9, 2026
7 conditions5 sponsors5 locations
NCT04876456
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs
PHASE2Active, not recruiting
50 participants
Started: Jun 10, 2021 · Completed: Jan 31, 2027
4 conditions3 sponsors1 location
NCT04631744
Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC)
PHASE2Recruiting
30 participants
Started: Mar 3, 2021 · Completed: Jul 31, 2027
1 condition2 sponsors4 locations
NCT04477512
Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)
PHASE1Active, not recruiting
18 participants
Started: Feb 19, 2021 · Completed: Sep 11, 2025
1 condition3 sponsors1 location
NCT04551430
Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma
PHASE2Active, not recruiting
105 participants
Started: Jan 5, 2021 · Completed: Feb 1, 2029
1 condition3 sponsors4 locations
NCT04412629
Cabozantinib in High Grade Neuroendocrine Neoplasms
PHASE2Recruiting
35 participants
Started: Nov 24, 2020 · Completed: Mar 31, 2027
1 condition2 sponsors1 location
NCT04413123
Cabozantinib In Combo With NIVO + IPI In Advanced NCCRCC
PHASE2Active, not recruiting
60 participants
Started: Nov 5, 2020 · Completed: Jun 20, 2026
8 conditions3 sponsors4 locations
NCT04472767
Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma
PHASE2Recruiting
35 participants
Started: Aug 7, 2020 · Completed: Sep 1, 2027
2 conditions2 sponsors1 location